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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Smad3 (
Mus musculus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IDA
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
ISO
GO:0001501
skeletal system development
IGI
GO:0001649
osteoblast differentiation
IMP
GO:0001666
response to hypoxia
ISO
GO:0001701
in utero embryonic development
IGI
GO:0001707
mesoderm formation
IMP
GO:0001756
somitogenesis
IMP
GO:0001836
release of cytochrome c from mitochondria
ISO
GO:0001889
liver development
IGI
GO:0001933
negative regulation of protein phosphorylation
ISO
GO:0001947
heart looping
IGI
GO:0002076
osteoblast development
IGI
GO:0002520
immune system development
IGI
GO:0006351
transcription, DNA-dependent
ISO
GO:0006355
regulation of transcription, DNA-dependent
IEA
GO:0006366
transcription from RNA polymerase II promoter
TAS
GO:0006810
transport
ISO
GO:0006917
induction of apoptosis
ISO
GO:0006919
activation of caspase activity
ISO
GO:0006955
immune response
ISO
GO:0007050
cell cycle arrest
ISO
GO:0007179
transforming growth factor beta receptor signaling pathway
ISO
GO:0007179
transforming growth factor beta receptor signaling pathway
TAS
GO:0007183
SMAD protein complex assembly
ISO
GO:0007369
gastrulation
IGI
GO:0007492
endoderm development
IGI
GO:0008285
negative regulation of cell proliferation
ISO
GO:0008633
activation of pro-apoptotic gene products
ISO
GO:0008637
apoptotic mitochondrial changes
ISO
GO:0009880
embryonic pattern specification
IGI
GO:0010694
positive regulation of alkaline phosphatase activity
ISO
GO:0010718
positive regulation of epithelial to mesenchymal transition
ISO
GO:0016202
regulation of striated muscle tissue development
IDA
GO:0017015
regulation of transforming growth factor beta receptor signaling pathway
IDA
GO:0017015
regulation of transforming growth factor beta receptor signaling pathway
ISO
GO:0019049
evasion of host defenses by virus
ISO
GO:0030308
negative regulation of cell growth
ISO
GO:0030335
positive regulation of cell migration
ISO
GO:0030501
positive regulation of bone mineralization
ISO
GO:0030878
thyroid gland development
IGI
GO:0032731
positive regulation of interleukin-1 beta production
ISO
GO:0032909
regulation of transforming growth factor beta2 production
ISO
GO:0032916
positive regulation of transforming growth factor beta3 production
ISO
GO:0035413
positive regulation of catenin import into nucleus
ISO
GO:0042110
T cell activation
IMP
GO:0042177
negative regulation of protein catabolic process
ISO
GO:0042993
positive regulation of transcription factor import into nucleus
ISO
GO:0043066
negative regulation of apoptosis
ISO
GO:0045216
cell-cell junction organization
ISO
GO:0045668
negative regulation of osteoblast differentiation
IGI
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
ISO
GO:0045930
negative regulation of mitotic cell cycle
ISO
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IGI
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
ISO
GO:0048340
paraxial mesoderm morphogenesis
IMP
GO:0048589
developmental growth
IGI
GO:0048617
embryonic foregut morphogenesis
IGI
GO:0048701
embryonic cranial skeleton morphogenesis
IGI
GO:0050678
regulation of epithelial cell proliferation
IMP
GO:0050728
negative regulation of inflammatory response
IMP
GO:0050776
regulation of immune response
IMP
GO:0050821
protein stabilization
ISO
GO:0050927
positive regulation of positive chemotaxis
ISO
GO:0051098
regulation of binding
IDA
GO:0051496
positive regulation of stress fiber assembly
ISO
GO:0051894
positive regulation of focal adhesion assembly
ISO
GO:0060039
pericardium development
IGI
GO:0060290
transdifferentiation
ISO
GO:0061045
negative regulation of wound healing
IMP
GO:0070306
lens fiber cell differentiation
IMP
GO:0090263
positive regulation of canonical Wnt receptor signaling pathway
ISO
cellular_component
GO:0005622
intracellular
IEA
GO:0005634
nucleus
IDA
GO:0005634
nucleus
ISO
GO:0005637
nuclear inner membrane
ISO
GO:0005667
transcription factor complex
ISO
GO:0005737
cytoplasm
IDA
GO:0005737
cytoplasm
ISO
GO:0005886
plasma membrane
IDA
GO:0043234
protein complex
ISO
GO:0043235
receptor complex
ISO
GO:0071141
SMAD protein complex
ISO
molecular_function
GO:0000987
core promoter proximal region sequence-specific DNA binding
ISO
GO:0001102
RNA polymerase II activating transcription factor binding
ISO
GO:0003677
DNA binding
ISO
GO:0003690
double-stranded DNA binding
IDA
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA
GO:0003700
sequence-specific DNA binding transcription factor activity
ISO
GO:0003706
ligand-regulated transcription factor activity
ISO
GO:0005160
transforming growth factor beta receptor binding
ISO
GO:0005515
protein binding
IPI
GO:0005518
collagen binding
IPI
GO:0008013
beta-catenin binding
ISO
GO:0008134
transcription factor binding
IPI
GO:0008134
transcription factor binding
ISO
GO:0008270
zinc ion binding
ISO
GO:0019901
protein kinase binding
ISO
GO:0019902
phosphatase binding
ISO
GO:0030618
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
ISO
GO:0031490
chromatin DNA binding
IDA
GO:0031625
ubiquitin protein ligase binding
ISO
GO:0042803
protein homodimerization activity
ISO
GO:0043565
sequence-specific DNA binding
ISO
GO:0044212
transcription regulatory region DNA binding
ISO
GO:0046332
SMAD binding
ISO
GO:0046872
metal ion binding
IEA
GO:0070410
co-SMAD binding
ISO
GO:0070412
R-SMAD binding
ISO
Protein-protein interaction details for Smad3 (
Mus musculus
)
(Information is obtained from BioGRID)
Interacting mouse protein
Experiment
Type
PubMed ID
Gsk3b
Affinity Capture-Western
physical
18172167
Smad4
Affinity Capture-Western
physical
17226765
Snai1
Affinity Capture-Western
physical
19597490
Hif1a
Affinity Capture-Western
physical
17053163
Foxh1
Two-hybrid
physical
20211142
Myod1
Two-hybrid
physical
20211142
Vdr
Two-hybrid
physical
20211142
Gata4
Affinity Capture-Western
physical
14662776
Gata4
Reconstituted Complex
physical
14662776
Gata4
Two-hybrid
physical
14662776
Smad4
Affinity Capture-Western
physical
12672795
Axin1
Affinity Capture-Western
physical
16601693
Axin1
Affinity Capture-Western
physical
16601693
Ubc
Affinity Capture-Western
physical
22045334
Ubc
Affinity Capture-Western
physical
22045334
Smad4
Affinity Capture-Western
physical
22045334