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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Smad3 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0001501skeletal system developmentIGI
GO:0001649osteoblast differentiationIMP
GO:0001666response to hypoxiaISO
GO:0001701in utero embryonic developmentIGI
GO:0001707mesoderm formationIMP
GO:0001756somitogenesisIMP
GO:0001836release of cytochrome c from mitochondriaISO
GO:0001889liver developmentIGI
GO:0001933negative regulation of protein phosphorylationISO
GO:0001947heart loopingIGI
GO:0002076osteoblast developmentIGI
GO:0002520immune system developmentIGI
GO:0006351transcription, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006810transportISO
GO:0006917induction of apoptosisISO
GO:0006919activation of caspase activityISO
GO:0006955immune responseISO
GO:0007050cell cycle arrestISO
GO:0007179transforming growth factor beta receptor signaling pathwayISO
GO:0007179transforming growth factor beta receptor signaling pathwayTAS
GO:0007183SMAD protein complex assemblyISO
GO:0007369gastrulationIGI
GO:0007492endoderm developmentIGI
GO:0008285negative regulation of cell proliferationISO
GO:0008633activation of pro-apoptotic gene productsISO
GO:0008637apoptotic mitochondrial changesISO
GO:0009880embryonic pattern specificationIGI
GO:0010694positive regulation of alkaline phosphatase activityISO
GO:0010718positive regulation of epithelial to mesenchymal transitionISO
GO:0016202regulation of striated muscle tissue developmentIDA
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayISO
GO:0019049evasion of host defenses by virusISO
GO:0030308negative regulation of cell growthISO
GO:0030335positive regulation of cell migrationISO
GO:0030501positive regulation of bone mineralizationISO
GO:0030878thyroid gland developmentIGI
GO:0032731positive regulation of interleukin-1 beta productionISO
GO:0032909regulation of transforming growth factor beta2 productionISO
GO:0032916positive regulation of transforming growth factor beta3 productionISO
GO:0035413positive regulation of catenin import into nucleusISO
GO:0042110T cell activationIMP
GO:0042177negative regulation of protein catabolic processISO
GO:0042993positive regulation of transcription factor import into nucleusISO
GO:0043066negative regulation of apoptosisISO
GO:0045216cell-cell junction organizationISO
GO:0045668negative regulation of osteoblast differentiationIGI
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045930negative regulation of mitotic cell cycleISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0048340paraxial mesoderm morphogenesisIMP
GO:0048589developmental growthIGI
GO:0048617embryonic foregut morphogenesisIGI
GO:0048701embryonic cranial skeleton morphogenesisIGI
GO:0050678regulation of epithelial cell proliferationIMP
GO:0050728negative regulation of inflammatory responseIMP
GO:0050776regulation of immune responseIMP
GO:0050821protein stabilizationISO
GO:0050927positive regulation of positive chemotaxisISO
GO:0051098regulation of bindingIDA
GO:0051496positive regulation of stress fiber assemblyISO
GO:0051894positive regulation of focal adhesion assemblyISO
GO:0060039pericardium developmentIGI
GO:0060290transdifferentiationISO
GO:0061045negative regulation of wound healingIMP
GO:0070306lens fiber cell differentiationIMP
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayISO
cellular_component
GO:0005622intracellularIEA
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005637nuclear inner membraneISO
GO:0005667transcription factor complexISO
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0005886plasma membraneIDA
GO:0043234protein complexISO
GO:0043235receptor complexISO
GO:0071141SMAD protein complexISO
molecular_function
GO:0000987core promoter proximal region sequence-specific DNA bindingISO
GO:0001102RNA polymerase II activating transcription factor bindingISO
GO:0003677DNA bindingISO
GO:0003690double-stranded DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0003706ligand-regulated transcription factor activityISO
GO:0005160transforming growth factor beta receptor bindingISO
GO:0005515protein bindingIPI
GO:0005518collagen bindingIPI
GO:0008013beta-catenin bindingISO
GO:0008134transcription factor bindingIPI
GO:0008134transcription factor bindingISO
GO:0008270zinc ion bindingISO
GO:0019901protein kinase bindingISO
GO:0019902phosphatase bindingISO
GO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityISO
GO:0031490chromatin DNA bindingIDA
GO:0031625ubiquitin protein ligase bindingISO
GO:0042803protein homodimerization activityISO
GO:0043565sequence-specific DNA bindingISO
GO:0044212transcription regulatory region DNA bindingISO
GO:0046332SMAD bindingISO
GO:0046872metal ion bindingIEA
GO:0070410co-SMAD bindingISO
GO:0070412R-SMAD bindingISO

Protein-protein interaction details for Smad3 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Gsk3bAffinity Capture-Westernphysical18172167
Smad4Affinity Capture-Westernphysical17226765
Snai1Affinity Capture-Westernphysical19597490
Hif1aAffinity Capture-Westernphysical17053163
Foxh1Two-hybridphysical20211142
Myod1Two-hybridphysical20211142
VdrTwo-hybridphysical20211142
Gata4Affinity Capture-Westernphysical14662776
Gata4Reconstituted Complexphysical14662776
Gata4Two-hybridphysical14662776
Smad4Affinity Capture-Westernphysical12672795
Axin1Affinity Capture-Westernphysical16601693
Axin1Affinity Capture-Westernphysical16601693
UbcAffinity Capture-Westernphysical22045334
UbcAffinity Capture-Westernphysical22045334
Smad4Affinity Capture-Westernphysical22045334