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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Sox2 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterIGI
GO:0001649osteoblast differentiationISO
GO:0001708cell fate specificationIMP
GO:0001714endodermal cell fate specificationISO
GO:0002052positive regulation of neuroblast proliferationIMP
GO:0006351transcription, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentIDA
GO:0006355regulation of transcription, DNA-dependentISO
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0007050cell cycle arrestISO
GO:0007275multicellular organismal developmentIEA
GO:0007605sensory perception of soundIMP
GO:0010468regulation of gene expressionISO
GO:0019827stem cell maintenanceIMP
GO:0021879forebrain neuron differentiationIMP
GO:0021984adenohypophysis developmentIMP
GO:0021987cerebral cortex developmentIMP
GO:0030178negative regulation of Wnt receptor signaling pathwayIGI
GO:0030539male genitalia developmentIMP
GO:0030858positive regulation of epithelial cell differentiationIDA
GO:0030910olfactory placode formationIGI
GO:0032526response to retinoic acidIDA
GO:0035019somatic stem cell maintenanceISO
GO:0042221response to chemical stimulusIDA
GO:0042472inner ear morphogenesisIMP
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic processISO
GO:0043410positive regulation of MAPKKK cascadeISO
GO:0043586tongue developmentIMP
GO:0045165cell fate commitmentIDA
GO:0045596negative regulation of cell differentiationIMP
GO:0045665negative regulation of neuron differentiationIDA
GO:0045666positive regulation of neuron differentiationIMP
GO:0045668negative regulation of osteoblast differentiationIDA
GO:0045747positive regulation of Notch signaling pathwayIDA
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046148pigment biosynthetic processIMP
GO:0048286lung alveolus developmentIDA
GO:0048568embryonic organ developmentIMP
GO:0048646anatomical structure formation involved in morphogenesisIMP
GO:0048663neuron fate commitmentIMP
GO:0048852diencephalon morphogenesisIMP
GO:0048863stem cell differentiationIDA
GO:0050680negative regulation of epithelial cell proliferationISO
GO:0050910detection of mechanical stimulus involved in sensory perception of soundIMP
GO:0050973detection of mechanical stimulus involved in equilibrioceptionIMP
GO:0060042retina morphogenesis in camera-type eyeIMP
GO:0060235lens induction in camera-type eyeIGI
GO:0060441epithelial tube branching involved in lung morphogenesisIDA
GO:0070848response to growth factor stimulusISO
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayIDA
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayISO
cellular_component
GO:0005625soluble fractionIDA
GO:0005634nucleusIC
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005667transcription factor complexIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0005829cytosolISO
molecular_function
GO:0000976transcription regulatory region sequence-specific DNA bindingISO
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISO
GO:0003677DNA bindingIDA
GO:0003677DNA bindingIGI
GO:0003677DNA bindingISO
GO:0003682chromatin bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0035198miRNA bindingISO
GO:0043565sequence-specific DNA bindingIDA
GO:0043565sequence-specific DNA bindingISO
GO:0044212transcription regulatory region DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingISO

Protein-protein interaction details for Sox2 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Alx4Two-hybridphysical20211142
ErgTwo-hybridphysical20211142
Pax6Two-hybridphysical20211142
Pou5f1Affinity Capture-MSphysical20362541
NanogAffinity Capture-Westernphysical18454139
Xpo4Affinity Capture-MSphysical19349578
Xpo4Affinity Capture-Westernphysical19349578
Xpo4Reconstituted Complexphysical19349578
Ctnnb1Phenotypic Suppressiongenetic15781477
Ctnnb1Affinity Capture-Westernphysical15781477
Ube2iBiochemical Activityphysical17097055
Uba2Biochemical Activityphysical17097055
Sae1Biochemical Activityphysical17097055
Pou5f1Affinity Capture-Westernphysical15863505
Pou5f1Affinity Capture-Westernphysical15863505
Hdac1Reconstituted Complexphysical21321941
Hdac1Affinity Capture-Westernphysical21321941
UbcAffinity Capture-Westernphysical19591226