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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Tcf7l2 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0001568blood vessel developmentISO
GO:0006351transcription, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentIDA
GO:0006357regulation of transcription from RNA polymerase II promoterIMP
GO:0006357regulation of transcription from RNA polymerase II promoterISO
GO:0006916anti-apoptosisISO
GO:0007050cell cycle arrestISO
GO:0008283cell proliferationISO
GO:0009749response to glucose stimulusIMP
GO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic processISO
GO:0014003oligodendrocyte developmentIMP
GO:0016055Wnt receptor signaling pathwayIDA
GO:0016055Wnt receptor signaling pathwayIGI
GO:0021915neural tube developmentIGI
GO:0021983pituitary gland developmentIMP
GO:0030282bone mineralizationIGI
GO:0030514negative regulation of BMP signaling pathwayIMP
GO:0030538embryonic genitalia morphogenesisIGI
GO:0031641regulation of myelinationIMP
GO:0032024positive regulation of insulin secretionIMP
GO:0032024positive regulation of insulin secretionISO
GO:0032092positive regulation of protein bindingISO
GO:0032252secretory granule localizationIMP
GO:0032350regulation of hormone metabolic processISO
GO:0035019somatic stem cell maintenanceIGI
GO:0035019somatic stem cell maintenanceIMP
GO:0035411catenin import into nucleusIDA
GO:0040037negative regulation of fibroblast growth factor receptor signaling pathwayIMP
GO:0042475odontogenesis of dentine-containing toothIGI
GO:0042593glucose homeostasisISO
GO:0043065positive regulation of apoptosisIMP
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityISO
GO:0043570maintenance of DNA repeat elementsISO
GO:0043588skin developmentIGI
GO:0044334canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transitionISO
GO:0045444fat cell differentiationISO
GO:0045599negative regulation of fat cell differentiationIMP
GO:0045892negative regulation of transcription, DNA-dependentISO
GO:0045893positive regulation of transcription, DNA-dependentIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046621negative regulation of organ growthIMP
GO:0046827positive regulation of protein export from nucleusISO
GO:0048557embryonic digestive tract morphogenesisIGI
GO:0048619embryonic hindgut morphogenesisIGI
GO:0048625myoblast cell fate commitmentIMP
GO:0048625myoblast cell fate commitmentISO
GO:0048641regulation of skeletal muscle tissue developmentIMP
GO:0048660regulation of smooth muscle cell proliferationISO
GO:0048713regulation of oligodendrocyte differentiationIMP
GO:0050679positive regulation of epithelial cell proliferationIMP
GO:0051897positive regulation of protein kinase B signaling cascadeISO
GO:0060070canonical Wnt receptor signaling pathwayIMP
GO:0060325face morphogenesisIGI
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusIMP
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusISO
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayISO
cellular_component
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005654nucleoplasmISO
GO:0005667transcription factor complexIDA
GO:0005829cytosolIDA
GO:0032993protein-DNA complexISO
GO:0070369beta-catenin-TCF7L2 complexISO
molecular_function
GO:0003677DNA bindingIEA
GO:0003682chromatin bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIBA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0005515protein bindingIPI
GO:0008013beta-catenin bindingIDA
GO:0008013beta-catenin bindingIPI
GO:0008013beta-catenin bindingISO
GO:0008134transcription factor bindingISO
GO:0019901protein kinase bindingISO
GO:0035257nuclear hormone receptor bindingISO
GO:0043565sequence-specific DNA bindingIBA
GO:0043565sequence-specific DNA bindingISO
GO:0044212transcription regulatory region DNA bindingIBA
GO:0044212transcription regulatory region DNA bindingISO
GO:0045295gamma-catenin bindingISO
GO:0070016armadillo repeat domain bindingISO

Protein-protein interaction details for Tcf7l2 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Hnf4aAffinity Capture-Westernphysical19805521
Hnf4aAffinity Capture-Westernphysical19805521
Ctnnb1Affinity Capture-Westernphysical19805521
Ctnnb1Affinity Capture-Westernphysical19503085
Hdac1Affinity Capture-Westernphysical19503085
Hdac2Affinity Capture-Westernphysical19503085
Ctnnb1Phenotypic Suppressiongenetic15778706
Ctnnb1Affinity Capture-Westernphysical12861022
Ctnnb1Phenotypic Suppressiongenetic12861022
Ctnnb1Affinity Capture-Westernphysical17053159