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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for EZH2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006325 chromatin organization TAS GO:0006355 regulation of transcription, DNA-dependent TAS GO:0016568 chromatin modification IEA GO:0016571 histone methylation IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP cellular_component GO:0005634 nucleus IEA GO:0035098 ESC/E(Z) complex IDA molecular_function GO:0003677 DNA binding IEA GO:0005515 protein binding IPI GO:0008168 methyltransferase activity IEA GO:0016740 transferase activity IEA GO:0018024 histone-lysine N-methyltransferase activity IEA GO:0042054 histone methyltransferase activity IDA

Protein-protein interaction details for EZH2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID VAV1 Two-hybrid physical 8649418 EED Two-hybrid physical 9584197 CCDC85B Two-hybrid physical 16189514 VAV1 Reconstituted Complex physical 8649418 VAV1 Affinity Capture-Western physical 8649418 ATRX Two-hybrid physical 9499421 ATRX Two-hybrid physical 9499421 ATRX Reconstituted Complex physical 9499421 ATRX Reconstituted Complex physical 9499421 EED Two-hybrid physical 9584197 EED Affinity Capture-Western physical 9584197 EED Affinity Capture-Western physical 10581039 EED Affinity Capture-Western physical 10581039 HDAC1 Affinity Capture-Western physical 10581039 HDAC2 Affinity Capture-Western physical 10581039 HDAC1 Affinity Capture-Western physical 10581039 HDAC2 Affinity Capture-Western physical 10581039 EED Co-fractionation physical 10581039 PHF1 Two-hybrid physical 11571280 EED Two-hybrid physical 9742080 EED Reconstituted Complex physical 9742080 EED Reconstituted Complex physical 9742080 EED Affinity Capture-Western physical 9742080 ATP1A1 Two-hybrid physical 16169070 NINL Two-hybrid physical 16169070 PSMB6 Two-hybrid physical 16169070 WDR61 Two-hybrid physical 16169070 RPN2 Two-hybrid physical 16169070 WSB2 Two-hybrid physical 16169070 GTF3C1 Two-hybrid physical 16169070 KLHDC2 Two-hybrid physical 16169070 PIN4 Two-hybrid physical 16169070 POLA2 Two-hybrid physical 16169070 EED Co-purification physical 15385962 EED Reconstituted Complex physical 15225548 SUZ12 Affinity Capture-Western physical 15882624 EED Affinity Capture-Western physical 15882624 VAV1 Affinity Capture-Western physical 15882624 ZMYND11 Affinity Capture-Western physical 16565076 E2F6 Affinity Capture-Western physical 16565076 SUZ12 Affinity Capture-Western physical 18453536 SNAI1 Affinity Capture-Western physical 18519590 SUZ12 Affinity Capture-Western physical 18931660 EED Affinity Capture-Western physical 18931660 JARID2 Affinity Capture-MS physical 20123894 MTF2 Affinity Capture-MS physical 20123894 JARID2 Affinity Capture-Western physical 20123894 MTF2 Affinity Capture-Western physical 20123894 SUZ12 Affinity Capture-MS physical 20123894 RBBP4 Affinity Capture-MS physical 20123894 JARID2 Affinity Capture-Western physical 20123894 MTF2 Affinity Capture-Western physical 20123894 JARID2 Reconstituted Complex physical 20123894 KDM2B Affinity Capture-Western physical 19202064 EZH1 Affinity Capture-Western physical 19026781 EZH1 Affinity Capture-Western physical 19026781 EZH2 Affinity Capture-Western physical 19026781 SUZ12 Affinity Capture-Western physical 19026781 EED Affinity Capture-Western physical 19026781 SUZ12 Affinity Capture-Western physical 19026781 EED Affinity Capture-Western physical 19026781 EZH1 Affinity Capture-Western physical 19026780 EED Affinity Capture-Western physical 19026780 SUZ12 Affinity Capture-Western physical 19026780 EED Affinity Capture-Western physical 19026780 CTNNB1 Affinity Capture-Western physical 19661437 CTNNB1 Affinity Capture-Western physical 19661437 EWSR1 Two-hybrid physical 20211142 HIST1H3A Biochemical Activity physical 16431907 HIST1H1A Reconstituted Complex physical 16431907 DNMT1 Reconstituted Complex physical 16357870 DNMT3A Reconstituted Complex physical 16357870 DNMT3B Reconstituted Complex physical 16357870 DNMT1 Affinity Capture-Western physical 16357870 DNMT3A Affinity Capture-Western physical 16357870 DNMT3B Affinity Capture-Western physical 16357870 DNMT1 Affinity Capture-Western physical 16357870 DNMT3A Affinity Capture-Western physical 16357870 DNMT3B Affinity Capture-Western physical 16357870 EED Affinity Capture-Western physical 16314526 AKT1 Affinity Capture-Western physical 16224021 AKT1 Affinity Capture-Western physical 16224021 AKT1 Biochemical Activity physical 16224021 HIST1H3A Biochemical Activity physical 16224021 HIST1H3A Affinity Capture-Western physical 16224021 KDM5A Affinity Capture-Western physical 18483221 KDM5A Affinity Capture-Western physical 18483221 SUZ12 Affinity Capture-Western physical 18483221 SUZ12 Affinity Capture-Western physical 18483221 SETD8 Co-purification physical 12351676 SIRT1 Affinity Capture-Western physical 15684044 SIRT1 Affinity Capture-Western physical 15684044 PHF1 Affinity Capture-MS physical 18385154 EPC1 Two-hybrid physical 15536069 EPC1 Affinity Capture-Western physical 15536069 EPC1 Affinity Capture-Western physical 15536069 E2F6 Affinity Capture-Western physical 15536069 E2F6 Affinity Capture-Western physical 15536069 HDAC1 Affinity Capture-Western physical 15520282 MYOD1 Affinity Capture-Western physical 15520282 YY1 Affinity Capture-Western physical 15520282 YY1 Co-localization physical 15520282 PHF1 Affinity Capture-Western physical 18285464 SUZ12 Affinity Capture-Western physical 18285464 EED Affinity Capture-Western physical 18285464 EED Affinity Capture-Western physical 18285464 RBL2 Affinity Capture-Western physical 15077161 RBL2 Affinity Capture-Western physical 15077161 RBL2 Reconstituted Complex physical 15077161 PHB2 Reconstituted Complex physical 17453341 EED Reconstituted Complex physical 17937919 PPP1R8 Affinity Capture-Western physical 17804093 PPP1R8 Affinity Capture-Western physical 17804093 PPP1R8 Reconstituted Complex physical 17804093 PPP1R8 Reconstituted Complex physical 17804093 WT1 Affinity Capture-Western physical 21378168 SUZ12 Affinity Capture-Western physical 21378168 WT1 Affinity Capture-Western physical 21378168 DNMT1 Affinity Capture-Western physical 21378168 SUZ12 Affinity Capture-Western physical 21378168 PPP1R8 Affinity Capture-Western physical 20671031 USP7 Reconstituted Complex physical 20800574 CDK1 Biochemical Activity physical 20935635 CDK2 Biochemical Activity physical 20935635 RUNX3 Affinity Capture-Western physical 20714105 RUNX3 Affinity Capture-Western physical 20714105 PPARG Affinity Capture-RNA physical 21151932 POU5F1 Affinity Capture-RNA physical 21151833 PHF19 Affinity Capture-Western physical 21143197 CDK1 Affinity Capture-Western physical 21135039 CDK1 Affinity Capture-Western physical 21135039 CDK1 Biochemical Activity physical 21135039 SUZ12 Affinity Capture-Western physical 21135039 EED Affinity Capture-Western physical 21135039 CDK1 Affinity Capture-Western physical 21131960 CDK1 Biochemical Activity physical 21131960 CDK1 Biochemical Activity physical 21123648 SUZ12 Biochemical Activity physical 21123648 EED Biochemical Activity physical 21123648 RBBP4 Biochemical Activity physical 21123648 SUZ12 Reconstituted Complex physical 21123648 EED Reconstituted Complex physical 21123648 RBBP4 Reconstituted Complex physical 21123648 HOTAIR Protein-RNA physical 21123648 HIST3H3 Biochemical Activity physical 21078963 MAPK8IP2 Two-hybrid physical 21900206 C7orf25 Two-hybrid physical 21900206 GADD45G Two-hybrid physical 21900206 TAF1D Two-hybrid physical 21900206 MAPKAPK3 Two-hybrid physical 21900206 RASA1 Two-hybrid physical 21900206 ATP1B1 Two-hybrid physical 21900206 RPS6KA5 Two-hybrid physical 21900206 TNFSF11 Two-hybrid physical 21900206 MAP3K7 Two-hybrid physical 21900206 TK1 Two-hybrid physical 21900206 DNAJB11 Two-hybrid physical 21900206 SMN1 Two-hybrid physical 21900206 PFDN1 Two-hybrid physical 21900206 ZAK Two-hybrid physical 21900206