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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Tlr4 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000187activation of MAPK activityIMP
GO:0002218activation of innate immune responseIMP
GO:0002224toll-like receptor signaling pathwayISO
GO:0002282microglial cell activation involved in immune responseISO
GO:0002537nitric oxide production involved in inflammatory responseIMP
GO:0002758innate immune response-activating signal transductionISO
GO:0006954inflammatory responseIEA
GO:0006955immune responseIEA
GO:0006979response to oxidative stressISO
GO:0007165signal transductionIEA
GO:0007250activation of NF-kappaB-inducing kinase activityNAS
GO:0007252I-kappaB phosphorylationISO
GO:0009617response to bacteriumIMP
GO:0010572positive regulation of platelet activationIMP
GO:0030890positive regulation of B cell proliferationIMP
GO:0031663lipopolysaccharide-mediated signaling pathwayISO
GO:0032496response to lipopolysaccharideIGI
GO:0032496response to lipopolysaccharideIMP
GO:0032496response to lipopolysaccharideISO
GO:0032497detection of lipopolysaccharideISO
GO:0032497detection of lipopolysaccharideTAS
GO:0032609interferon-gamma productionIGI
GO:0032689negative regulation of interferon-gamma productionIMP
GO:0032700negative regulation of interleukin-17 productionIMP
GO:0032707negative regulation of interleukin-23 productionIMP
GO:0032715negative regulation of interleukin-6 productionIMP
GO:0032720negative regulation of tumor necrosis factor productionIMP
GO:0032722positive regulation of chemokine productionIDA
GO:0032722positive regulation of chemokine productionISO
GO:0032727positive regulation of interferon-alpha productionIDA
GO:0032728positive regulation of interferon-beta productionIDA
GO:0032729positive regulation of interferon-gamma productionIMP
GO:0032732positive regulation of interleukin-1 productionIDA
GO:0032733positive regulation of interleukin-10 productionIDA
GO:0032735positive regulation of interleukin-12 productionIDA
GO:0032755positive regulation of interleukin-6 productionIDA
GO:0032755positive regulation of interleukin-6 productionIMP
GO:0032755positive regulation of interleukin-6 productionISO
GO:0032755positive regulation of interleukin-6 productionNAS
GO:0032757positive regulation of interleukin-8 productionISO
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0032760positive regulation of tumor necrosis factor productionIMP
GO:0032874positive regulation of stress-activated MAPK cascadeIDA
GO:0042116macrophage activationISO
GO:0042116macrophage activationISS
GO:0042346positive regulation of NF-kappaB import into nucleusISO
GO:0042535positive regulation of tumor necrosis factor biosynthetic processISO
GO:0042742defense response to bacteriumISO
GO:0043065positive regulation of apoptosisISO
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIDA
GO:0043388positive regulation of DNA bindingISO
GO:0045084positive regulation of interleukin-12 biosynthetic processISO
GO:0045087innate immune responseTAS
GO:0045348positive regulation of MHC class II biosynthetic processIMP
GO:0045359positive regulation of interferon-beta biosynthetic processIMP
GO:0045362positive regulation of interleukin-1 biosynthetic processNAS
GO:0045368positive regulation of interleukin-13 biosynthetic processNAS
GO:0045410positive regulation of interleukin-6 biosynthetic processNAS
GO:0045416positive regulation of interleukin-8 biosynthetic processISO
GO:0045429positive regulation of nitric oxide biosynthetic processIMP
GO:0045471response to ethanolISO
GO:0045576mast cell activationNAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046330positive regulation of JNK cascadeIDA
GO:0046330positive regulation of JNK cascadeIGI
GO:0050671positive regulation of lymphocyte proliferationIMP
GO:0050727regulation of inflammatory responseIMP
GO:0050729positive regulation of inflammatory responseISO
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISO
GO:0050829defense response to Gram-negative bacteriumIMP
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISO
GO:0051092positive regulation of NF-kappaB transcription factor activityISO
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processIDA
GO:0051930regulation of sensory perception of painISO
GO:0052033pathogen-associated molecular pattern dependent induction by symbiont of host innate immunityISO
GO:0060729intestinal epithelial structure maintenanceIMP
GO:0060907positive regulation of macrophage cytokine productionIMP
GO:0070373negative regulation of ERK1 and ERK2 cascadeIMP
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070430positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathwayIDA
GO:0070434positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayIDA
GO:0070542response to fatty acidISO
GO:0071222cellular response to lipopolysaccharideIMP
GO:0071223cellular response to lipoteichoic acidIMP
cellular_component
GO:0005737cytoplasmISO
GO:0005886plasma membraneISO
GO:0005887integral to plasma membraneISO
GO:0009897external side of plasma membraneISO
GO:0009986cell surfaceISO
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0031224intrinsic to membraneIEA
GO:0045121membrane raftISO
GO:0046696lipopolysaccharide receptor complexISO
GO:0048471perinuclear region of cytoplasmISO
molecular_function
GO:0001530lipopolysaccharide bindingISO
GO:0001875lipopolysaccharide receptor activityISO
GO:0004872receptor activityISO
GO:0004888transmembrane signaling receptor activityIEA
GO:0005515protein bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingISO

Protein-protein interaction details for Tlr4 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Cd14Affinity Capture-Westernphysical12196527
Irak1Affinity Capture-Westernphysical18562480
Bcl10Affinity Capture-Westernphysical16831874
Ticam2PCAphysical19378012
TirapPCAphysical19378012
Myd88PCAphysical19378012
Il10Phenotypic Suppressiongenetic19681597
Traf6Affinity Capture-Westernphysical19898473
Myd88Affinity Capture-Westernphysical19898473
Ube2nAffinity Capture-Westernphysical19898473
Traf3Affinity Capture-Westernphysical19898473
Ticam1Affinity Capture-Westernphysical19898473
Map3k7Affinity Capture-Westernphysical19898473
IkbkgAffinity Capture-Westernphysical19898473
Birc2Affinity Capture-Westernphysical19898473
Birc3Affinity Capture-Westernphysical19898473
Birc3Affinity Capture-Westernphysical19898473