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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Tlr4 (
Mus musculus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000187
activation of MAPK activity
IMP
GO:0002218
activation of innate immune response
IMP
GO:0002224
toll-like receptor signaling pathway
ISO
GO:0002282
microglial cell activation involved in immune response
ISO
GO:0002537
nitric oxide production involved in inflammatory response
IMP
GO:0002758
innate immune response-activating signal transduction
ISO
GO:0006954
inflammatory response
IEA
GO:0006955
immune response
IEA
GO:0006979
response to oxidative stress
ISO
GO:0007165
signal transduction
IEA
GO:0007250
activation of NF-kappaB-inducing kinase activity
NAS
GO:0007252
I-kappaB phosphorylation
ISO
GO:0009617
response to bacterium
IMP
GO:0010572
positive regulation of platelet activation
IMP
GO:0030890
positive regulation of B cell proliferation
IMP
GO:0031663
lipopolysaccharide-mediated signaling pathway
ISO
GO:0032496
response to lipopolysaccharide
IGI
GO:0032496
response to lipopolysaccharide
IMP
GO:0032496
response to lipopolysaccharide
ISO
GO:0032497
detection of lipopolysaccharide
ISO
GO:0032497
detection of lipopolysaccharide
TAS
GO:0032609
interferon-gamma production
IGI
GO:0032689
negative regulation of interferon-gamma production
IMP
GO:0032700
negative regulation of interleukin-17 production
IMP
GO:0032707
negative regulation of interleukin-23 production
IMP
GO:0032715
negative regulation of interleukin-6 production
IMP
GO:0032720
negative regulation of tumor necrosis factor production
IMP
GO:0032722
positive regulation of chemokine production
IDA
GO:0032722
positive regulation of chemokine production
ISO
GO:0032727
positive regulation of interferon-alpha production
IDA
GO:0032728
positive regulation of interferon-beta production
IDA
GO:0032729
positive regulation of interferon-gamma production
IMP
GO:0032732
positive regulation of interleukin-1 production
IDA
GO:0032733
positive regulation of interleukin-10 production
IDA
GO:0032735
positive regulation of interleukin-12 production
IDA
GO:0032755
positive regulation of interleukin-6 production
IDA
GO:0032755
positive regulation of interleukin-6 production
IMP
GO:0032755
positive regulation of interleukin-6 production
ISO
GO:0032755
positive regulation of interleukin-6 production
NAS
GO:0032757
positive regulation of interleukin-8 production
ISO
GO:0032760
positive regulation of tumor necrosis factor production
IDA
GO:0032760
positive regulation of tumor necrosis factor production
IMP
GO:0032874
positive regulation of stress-activated MAPK cascade
IDA
GO:0042116
macrophage activation
ISO
GO:0042116
macrophage activation
ISS
GO:0042346
positive regulation of NF-kappaB import into nucleus
ISO
GO:0042535
positive regulation of tumor necrosis factor biosynthetic process
ISO
GO:0042742
defense response to bacterium
ISO
GO:0043065
positive regulation of apoptosis
ISO
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB cascade
IDA
GO:0043388
positive regulation of DNA binding
ISO
GO:0045084
positive regulation of interleukin-12 biosynthetic process
ISO
GO:0045087
innate immune response
TAS
GO:0045348
positive regulation of MHC class II biosynthetic process
IMP
GO:0045359
positive regulation of interferon-beta biosynthetic process
IMP
GO:0045362
positive regulation of interleukin-1 biosynthetic process
NAS
GO:0045368
positive regulation of interleukin-13 biosynthetic process
NAS
GO:0045410
positive regulation of interleukin-6 biosynthetic process
NAS
GO:0045416
positive regulation of interleukin-8 biosynthetic process
ISO
GO:0045429
positive regulation of nitric oxide biosynthetic process
IMP
GO:0045471
response to ethanol
ISO
GO:0045576
mast cell activation
NAS
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0046330
positive regulation of JNK cascade
IDA
GO:0046330
positive regulation of JNK cascade
IGI
GO:0050671
positive regulation of lymphocyte proliferation
IMP
GO:0050727
regulation of inflammatory response
IMP
GO:0050729
positive regulation of inflammatory response
ISO
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
ISO
GO:0050829
defense response to Gram-negative bacterium
IMP
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
ISO
GO:0051092
positive regulation of NF-kappaB transcription factor activity
ISO
GO:0051770
positive regulation of nitric-oxide synthase biosynthetic process
IDA
GO:0051930
regulation of sensory perception of pain
ISO
GO:0052033
pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
ISO
GO:0060729
intestinal epithelial structure maintenance
IMP
GO:0060907
positive regulation of macrophage cytokine production
IMP
GO:0070373
negative regulation of ERK1 and ERK2 cascade
IMP
GO:0070374
positive regulation of ERK1 and ERK2 cascade
IDA
GO:0070430
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
IDA
GO:0070434
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
IDA
GO:0070542
response to fatty acid
ISO
GO:0071222
cellular response to lipopolysaccharide
IMP
GO:0071223
cellular response to lipoteichoic acid
IMP
cellular_component
GO:0005737
cytoplasm
ISO
GO:0005886
plasma membrane
ISO
GO:0005887
integral to plasma membrane
ISO
GO:0009897
external side of plasma membrane
ISO
GO:0009986
cell surface
ISO
GO:0016020
membrane
IEA
GO:0016021
integral to membrane
IEA
GO:0031224
intrinsic to membrane
IEA
GO:0045121
membrane raft
ISO
GO:0046696
lipopolysaccharide receptor complex
ISO
GO:0048471
perinuclear region of cytoplasm
ISO
molecular_function
GO:0001530
lipopolysaccharide binding
ISO
GO:0001875
lipopolysaccharide receptor activity
ISO
GO:0004872
receptor activity
ISO
GO:0004888
transmembrane signaling receptor activity
IEA
GO:0005515
protein binding
IPI
GO:0043548
phosphatidylinositol 3-kinase binding
ISO
Protein-protein interaction details for Tlr4 (
Mus musculus
)
(Information is obtained from BioGRID)
Interacting mouse protein
Experiment
Type
PubMed ID
Cd14
Affinity Capture-Western
physical
12196527
Irak1
Affinity Capture-Western
physical
18562480
Bcl10
Affinity Capture-Western
physical
16831874
Ticam2
PCA
physical
19378012
Tirap
PCA
physical
19378012
Myd88
PCA
physical
19378012
Il10
Phenotypic Suppression
genetic
19681597
Traf6
Affinity Capture-Western
physical
19898473
Myd88
Affinity Capture-Western
physical
19898473
Ube2n
Affinity Capture-Western
physical
19898473
Traf3
Affinity Capture-Western
physical
19898473
Ticam1
Affinity Capture-Western
physical
19898473
Map3k7
Affinity Capture-Western
physical
19898473
Ikbkg
Affinity Capture-Western
physical
19898473
Birc2
Affinity Capture-Western
physical
19898473
Birc3
Affinity Capture-Western
physical
19898473
Birc3
Affinity Capture-Western
physical
19898473