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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Tnf (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000060protein import into nucleus, translocationISO
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000185activation of MAPKKK activityISO
GO:0000187activation of MAPK activityISO
GO:0001775cell activationISO
GO:0001819positive regulation of cytokine productionISO
GO:0001932regulation of protein phosphorylationIDA
GO:0001934positive regulation of protein phosphorylationISO
GO:0002037negative regulation of L-glutamate transportISO
GO:0002439chronic inflammatory response to antigenic stimulusISO
GO:0002740negative regulation of cytokine secretion involved in immune responseISO
GO:0002876positive regulation of chronic inflammatory response to antigenic stimulusIGI
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIGI
GO:0006006glucose metabolic processIDA
GO:0006915apoptosisIGI
GO:0006915apoptosisISO
GO:0006916anti-apoptosisISO
GO:0006917induction of apoptosisIDA
GO:0006917induction of apoptosisIGI
GO:0006917induction of apoptosisISO
GO:0006919activation of caspase activityISO
GO:0006927transformed cell apoptosisISO
GO:0006927transformed cell apoptosisTAS
GO:0006952defense responseIMP
GO:0006954inflammatory responseISO
GO:0006954inflammatory responseTAS
GO:0006955immune responseIEA
GO:0006959humoral immune responseIMP
GO:0007165signal transductionISO
GO:0007254JNK cascadeIGI
GO:0007275multicellular organismal developmentIMP
GO:0008283cell proliferationTAS
GO:0008284positive regulation of cell proliferationTAS
GO:0008285negative regulation of cell proliferationISO
GO:0008624induction of apoptosis by extracellular signalsIDA
GO:0008624induction of apoptosis by extracellular signalsISO
GO:0008625induction of apoptosis via death domain receptorsIGI
GO:0008625induction of apoptosis via death domain receptorsISO
GO:0009615response to virusISO
GO:0009887organ morphogenesisIMP
GO:0019722calcium-mediated signalingISO
GO:0030198extracellular matrix organizationIDA
GO:0030316osteoclast differentiationIGI
GO:0030730sequestering of triglycerideISO
GO:0031334positive regulation of protein complex assemblyISO
GO:0031622positive regulation of fever generationIDA
GO:0032715negative regulation of interleukin-6 productionISO
GO:0032722positive regulation of chemokine productionISO
GO:0032729positive regulation of interferon-gamma productionIGI
GO:0032755positive regulation of interleukin-6 productionIDA
GO:0032800receptor biosynthetic processISO
GO:0033138positive regulation of peptidyl-serine phosphorylationISO
GO:0033209tumor necrosis factor-mediated signaling pathwayIDA
GO:0033209tumor necrosis factor-mediated signaling pathwayISO
GO:0034116positive regulation of heterotypic cell-cell adhesionISO
GO:0042127regulation of cell proliferationIDA
GO:0042346positive regulation of NF-kappaB import into nucleusISO
GO:0042742defense response to bacteriumIDA
GO:0043066negative regulation of apoptosisISO
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeISO
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIGI
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeISO
GO:0043243positive regulation of protein complex disassemblyISO
GO:0043406positive regulation of MAP kinase activityISO
GO:0043525positive regulation of neuron apoptosisISO
GO:0044130negative regulation of growth of symbiont in hostIGI
GO:0045071negative regulation of viral genome replicationISO
GO:0045080positive regulation of chemokine biosynthetic processISO
GO:0045123cellular extravasationIDA
GO:0045429positive regulation of nitric oxide biosynthetic processISO
GO:0045670regulation of osteoclast differentiationIDA
GO:0045672positive regulation of osteoclast differentiationISO
GO:0045840positive regulation of mitosisISO
GO:0045892negative regulation of transcription, DNA-dependentISO
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0045994positive regulation of translational initiation by ironIDA
GO:0046325negative regulation of glucose importIDA
GO:0046325negative regulation of glucose importISO
GO:0046330positive regulation of JNK cascadeIDA
GO:0046330positive regulation of JNK cascadeIGI
GO:0048661positive regulation of smooth muscle cell proliferationISO
GO:0050708regulation of protein secretionIDA
GO:0050715positive regulation of cytokine secretionISO
GO:0050796regulation of insulin secretionISO
GO:0050806positive regulation of synaptic transmissionISO
GO:0050830defense response to Gram-positive bacteriumIGI
GO:0050900leukocyte migrationIDA
GO:0050901leukocyte tethering or rollingISO
GO:0050995negative regulation of lipid catabolic processISO
GO:0051023regulation of immunoglobulin secretionIDA
GO:0051044positive regulation of membrane protein ectodomain proteolysisISO
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISO
GO:0051092positive regulation of NF-kappaB transcription factor activityISO
GO:0051222positive regulation of protein transportISO
GO:0051384response to glucocorticoid stimulusISO
GO:0051533positive regulation of NFAT protein import into nucleusISO
GO:0051798positive regulation of hair follicle developmentIMP
GO:0051897positive regulation of protein kinase B signaling cascadeIDA
GO:0060555induction of necroptosis by extracellular signalsISO
GO:0060557positive regulation of vitamin D biosynthetic processISO
GO:0060559positive regulation of calcidiol 1-monooxygenase activityISO
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIDA
GO:0060693regulation of branching involved in salivary gland morphogenesisIDA
GO:0060693regulation of branching involved in salivary gland morphogenesisIMP
GO:0061048negative regulation of branching involved in lung morphogenesisISO
GO:0070265necrotic cell deathISO
GO:0071230cellular response to amino acid stimulusIDA
GO:0071316cellular response to nicotineISO
GO:0071803positive regulation of podosome assemblyISO
cellular_component
GO:0001891phagocytic cupIDA
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceISO
GO:0005622intracellularIDA
GO:0005886plasma membraneIDA
GO:0005887integral to plasma membraneISO
GO:0005887integral to plasma membraneTAS
GO:0009897external side of plasma membraneIDA
GO:0009986cell surfaceISO
GO:0016020membraneIEA
GO:0016021integral to membraneISO
GO:0030141stored secretory granuleTAS
GO:0045121membrane raftIDA
GO:0045121membrane raftISO
GO:0055037recycling endosomeIDA
molecular_function
GO:0002020protease bindingIPI
GO:0002020protease bindingISO
GO:0005125cytokine activityIDA
GO:0005125cytokine activityISO
GO:0005164tumor necrosis factor receptor bindingIDA
GO:0005164tumor necrosis factor receptor bindingIPI
GO:0005164tumor necrosis factor receptor bindingISO
GO:0005164tumor necrosis factor receptor bindingTAS
GO:0005515protein bindingIPI
GO:0042802identical protein bindingISO
GO:0044212transcription regulatory region DNA bindingISO

Protein-protein interaction details for Tnf (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Ripk1Affinity Capture-Westernphysical18621737
Tnfrsf1aAffinity Capture-Westernphysical18621737
FaddAffinity Capture-Westernphysical18417150
Tmem115Reconstituted Complexphysical19955178
Ripk1Reconstituted Complexphysical19955178