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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Tnf (
Mus musculus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000060
protein import into nucleus, translocation
ISO
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IDA
GO:0000185
activation of MAPKKK activity
ISO
GO:0000187
activation of MAPK activity
ISO
GO:0001775
cell activation
ISO
GO:0001819
positive regulation of cytokine production
ISO
GO:0001932
regulation of protein phosphorylation
IDA
GO:0001934
positive regulation of protein phosphorylation
ISO
GO:0002037
negative regulation of L-glutamate transport
ISO
GO:0002439
chronic inflammatory response to antigenic stimulus
ISO
GO:0002740
negative regulation of cytokine secretion involved in immune response
ISO
GO:0002876
positive regulation of chronic inflammatory response to antigenic stimulus
IGI
GO:0002925
positive regulation of humoral immune response mediated by circulating immunoglobulin
IGI
GO:0006006
glucose metabolic process
IDA
GO:0006915
apoptosis
IGI
GO:0006915
apoptosis
ISO
GO:0006916
anti-apoptosis
ISO
GO:0006917
induction of apoptosis
IDA
GO:0006917
induction of apoptosis
IGI
GO:0006917
induction of apoptosis
ISO
GO:0006919
activation of caspase activity
ISO
GO:0006927
transformed cell apoptosis
ISO
GO:0006927
transformed cell apoptosis
TAS
GO:0006952
defense response
IMP
GO:0006954
inflammatory response
ISO
GO:0006954
inflammatory response
TAS
GO:0006955
immune response
IEA
GO:0006959
humoral immune response
IMP
GO:0007165
signal transduction
ISO
GO:0007254
JNK cascade
IGI
GO:0007275
multicellular organismal development
IMP
GO:0008283
cell proliferation
TAS
GO:0008284
positive regulation of cell proliferation
TAS
GO:0008285
negative regulation of cell proliferation
ISO
GO:0008624
induction of apoptosis by extracellular signals
IDA
GO:0008624
induction of apoptosis by extracellular signals
ISO
GO:0008625
induction of apoptosis via death domain receptors
IGI
GO:0008625
induction of apoptosis via death domain receptors
ISO
GO:0009615
response to virus
ISO
GO:0009887
organ morphogenesis
IMP
GO:0019722
calcium-mediated signaling
ISO
GO:0030198
extracellular matrix organization
IDA
GO:0030316
osteoclast differentiation
IGI
GO:0030730
sequestering of triglyceride
ISO
GO:0031334
positive regulation of protein complex assembly
ISO
GO:0031622
positive regulation of fever generation
IDA
GO:0032715
negative regulation of interleukin-6 production
ISO
GO:0032722
positive regulation of chemokine production
ISO
GO:0032729
positive regulation of interferon-gamma production
IGI
GO:0032755
positive regulation of interleukin-6 production
IDA
GO:0032800
receptor biosynthetic process
ISO
GO:0033138
positive regulation of peptidyl-serine phosphorylation
ISO
GO:0033209
tumor necrosis factor-mediated signaling pathway
IDA
GO:0033209
tumor necrosis factor-mediated signaling pathway
ISO
GO:0034116
positive regulation of heterotypic cell-cell adhesion
ISO
GO:0042127
regulation of cell proliferation
IDA
GO:0042346
positive regulation of NF-kappaB import into nucleus
ISO
GO:0042742
defense response to bacterium
IDA
GO:0043066
negative regulation of apoptosis
ISO
GO:0043122
regulation of I-kappaB kinase/NF-kappaB cascade
ISO
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB cascade
IDA
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB cascade
IGI
GO:0043123
positive regulation of I-kappaB kinase/NF-kappaB cascade
ISO
GO:0043243
positive regulation of protein complex disassembly
ISO
GO:0043406
positive regulation of MAP kinase activity
ISO
GO:0043525
positive regulation of neuron apoptosis
ISO
GO:0044130
negative regulation of growth of symbiont in host
IGI
GO:0045071
negative regulation of viral genome replication
ISO
GO:0045080
positive regulation of chemokine biosynthetic process
ISO
GO:0045123
cellular extravasation
IDA
GO:0045429
positive regulation of nitric oxide biosynthetic process
ISO
GO:0045670
regulation of osteoclast differentiation
IDA
GO:0045672
positive regulation of osteoclast differentiation
ISO
GO:0045840
positive regulation of mitosis
ISO
GO:0045892
negative regulation of transcription, DNA-dependent
ISO
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
ISO
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IGI
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
ISO
GO:0045994
positive regulation of translational initiation by iron
IDA
GO:0046325
negative regulation of glucose import
IDA
GO:0046325
negative regulation of glucose import
ISO
GO:0046330
positive regulation of JNK cascade
IDA
GO:0046330
positive regulation of JNK cascade
IGI
GO:0048661
positive regulation of smooth muscle cell proliferation
ISO
GO:0050708
regulation of protein secretion
IDA
GO:0050715
positive regulation of cytokine secretion
ISO
GO:0050796
regulation of insulin secretion
ISO
GO:0050806
positive regulation of synaptic transmission
ISO
GO:0050830
defense response to Gram-positive bacterium
IGI
GO:0050900
leukocyte migration
IDA
GO:0050901
leukocyte tethering or rolling
ISO
GO:0050995
negative regulation of lipid catabolic process
ISO
GO:0051023
regulation of immunoglobulin secretion
IDA
GO:0051044
positive regulation of membrane protein ectodomain proteolysis
ISO
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
ISO
GO:0051092
positive regulation of NF-kappaB transcription factor activity
ISO
GO:0051222
positive regulation of protein transport
ISO
GO:0051384
response to glucocorticoid stimulus
ISO
GO:0051533
positive regulation of NFAT protein import into nucleus
ISO
GO:0051798
positive regulation of hair follicle development
IMP
GO:0051897
positive regulation of protein kinase B signaling cascade
IDA
GO:0060555
induction of necroptosis by extracellular signals
ISO
GO:0060557
positive regulation of vitamin D biosynthetic process
ISO
GO:0060559
positive regulation of calcidiol 1-monooxygenase activity
ISO
GO:0060664
epithelial cell proliferation involved in salivary gland morphogenesis
IDA
GO:0060693
regulation of branching involved in salivary gland morphogenesis
IDA
GO:0060693
regulation of branching involved in salivary gland morphogenesis
IMP
GO:0061048
negative regulation of branching involved in lung morphogenesis
ISO
GO:0070265
necrotic cell death
ISO
GO:0071230
cellular response to amino acid stimulus
IDA
GO:0071316
cellular response to nicotine
ISO
GO:0071803
positive regulation of podosome assembly
ISO
cellular_component
GO:0001891
phagocytic cup
IDA
GO:0005576
extracellular region
IEA
GO:0005615
extracellular space
IDA
GO:0005615
extracellular space
ISO
GO:0005622
intracellular
IDA
GO:0005886
plasma membrane
IDA
GO:0005887
integral to plasma membrane
ISO
GO:0005887
integral to plasma membrane
TAS
GO:0009897
external side of plasma membrane
IDA
GO:0009986
cell surface
ISO
GO:0016020
membrane
IEA
GO:0016021
integral to membrane
ISO
GO:0030141
stored secretory granule
TAS
GO:0045121
membrane raft
IDA
GO:0045121
membrane raft
ISO
GO:0055037
recycling endosome
IDA
molecular_function
GO:0002020
protease binding
IPI
GO:0002020
protease binding
ISO
GO:0005125
cytokine activity
IDA
GO:0005125
cytokine activity
ISO
GO:0005164
tumor necrosis factor receptor binding
IDA
GO:0005164
tumor necrosis factor receptor binding
IPI
GO:0005164
tumor necrosis factor receptor binding
ISO
GO:0005164
tumor necrosis factor receptor binding
TAS
GO:0005515
protein binding
IPI
GO:0042802
identical protein binding
ISO
GO:0044212
transcription regulatory region DNA binding
ISO
Protein-protein interaction details for Tnf (
Mus musculus
)
(Information is obtained from BioGRID)
Interacting mouse protein
Experiment
Type
PubMed ID
Ripk1
Affinity Capture-Western
physical
18621737
Tnfrsf1a
Affinity Capture-Western
physical
18621737
Fadd
Affinity Capture-Western
physical
18417150
Tmem115
Reconstituted Complex
physical
19955178
Ripk1
Reconstituted Complex
physical
19955178