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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FLT3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002318 myeloid progenitor cell differentiation TAS GO:0002328 pro-B cell differentiation IEA GO:0002572 pro-T cell differentiation IEA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS GO:0008284 positive regulation of cell proliferation TAS GO:0008285 negative regulation of cell proliferation IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade TAS GO:0018108 peptidyl-tyrosine phosphorylation TAS GO:0019221 cytokine-mediated signaling pathway TAS GO:0030097 hemopoiesis IDA GO:0030098 lymphocyte differentiation IEA GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS GO:0042981 regulation of apoptosis TAS GO:0043406 positive regulation of MAP kinase activity TAS GO:0043410 positive regulation of MAPKKK cascade TAS GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS GO:0045578 negative regulation of B cell differentiation IEA GO:0046777 protein autophosphorylation TAS GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0071345 cellular response to cytokine stimulus TAS cellular_component GO:0005783 endoplasmic reticulum IEA GO:0005788 endoplasmic reticulum lumen IEA GO:0005887 integral to plasma membrane TAS GO:0009986 cell surface IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS GO:0004872 receptor activity IEA GO:0004896 cytokine receptor activity TAS GO:0005021 vascular endothelial growth factor-activated receptor activity TAS GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0042803 protein homodimerization activity TAS GO:0043548 phosphatidylinositol 3-kinase binding IEA

Protein-protein interaction details for FLT3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SOCS1 Affinity Capture-Western physical 10022833 GRB2 Affinity Capture-Western physical 10080542 UBC Affinity Capture-Western physical 18394702 HSP90AA1 Affinity Capture-Western physical 18394702 IKBKG Reconstituted Complex physical 20098747 UBC Affinity Capture-Western physical 15150124 UBE2L6 Affinity Capture-Western physical 20508617 UBE2L6 Reconstituted Complex physical 20508617 SIAH1 Reconstituted Complex physical 20508617 SIAH1 Affinity Capture-Western physical 20508617