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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIRT3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006342 chromatin silencing IEA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006471 protein ADP-ribosylation TAS GO:0006476 protein deacetylation IDA GO:0006476 protein deacetylation IEA cellular_component GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IDA GO:0005759 mitochondrial matrix IEA GO:0016020 membrane IEA molecular_function GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0005515 protein binding IPI GO:0008270 zinc ion binding IDA GO:0008270 zinc ion binding IEA GO:0016787 hydrolase activity IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA GO:0046872 metal ion binding IEA GO:0070403 NAD+ binding IEA

Protein-protein interaction details for SIRT3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PEX5 Two-hybrid physical 16189514 FOXO3 Affinity Capture-Western physical 18781224 XRCC6 Affinity Capture-Western physical 18710944 XRCC6 Reconstituted Complex physical 18710944 XRCC6 Biochemical Activity physical 18710944 SIRT4 Affinity Capture-Western physical 17715127 SIRT5 Affinity Capture-Western physical 17715127 ATP5A1 Affinity Capture-Western physical 19343720 HSPA4 Affinity Capture-Western physical 19343720 ATP5A1 Affinity Capture-MS physical 19343720 ATP5B Affinity Capture-MS physical 19343720 HSPD1 Affinity Capture-MS physical 19343720 NCAPD2 Affinity Capture-MS physical 19343720 GRN Affinity Capture-MS physical 19343720 HSPA5 Affinity Capture-MS physical 19343720 HSPA1L Affinity Capture-MS physical 19343720 HSP90B1 Affinity Capture-MS physical 19343720 CMYA5 Affinity Capture-MS physical 19343720 PGAP1 Affinity Capture-MS physical 19343720 RIF1 Affinity Capture-MS physical 19343720 HSPA9 Affinity Capture-MS physical 19343720 SBF1 Affinity Capture-MS physical 19343720 HERC2 Affinity Capture-MS physical 19343720 TTF2 Affinity Capture-MS physical 19343720 SNTB1 Affinity Capture-MS physical 19343720 UQCRH Affinity Capture-MS physical 19343720 UGDH Affinity Capture-MS physical 19343720 UBC Affinity Capture-Western physical 21840382 HSPD1 Affinity Capture-Western physical 21840382 HSPD1 Reconstituted Complex physical 21840382