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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SUZ12 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0008284 positive regulation of cell proliferation IEA GO:0016568 chromatin modification IEA GO:0016571 histone methylation IMP GO:0016574 histone ubiquitination IEA GO:0045596 negative regulation of cell differentiation IMP cellular_component GO:0001739 sex chromatin IEA GO:0005622 intracellular IEA GO:0005634 nucleus IEA GO:0035098 ESC/E(Z) complex IDA GO:0035098 ESC/E(Z) complex IMP molecular_function GO:0003682 chromatin binding IEA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0035064 methylated histone residue binding IDA GO:0042054 histone methyltransferase activity IMP GO:0046872 metal ion binding IEA

Protein-protein interaction details for SUZ12 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SETDB1 Co-purification physical 14536086 EED Co-purification physical 15385962 EED Reconstituted Complex physical 15225548 AEBP2 Reconstituted Complex physical 15225548 RBBP4 Reconstituted Complex physical 15225548 RBBP4 Reconstituted Complex physical 15225548 AEBP2 Reconstituted Complex physical 15225548 EZH2 Affinity Capture-Western physical 15882624 VAV1 Affinity Capture-Western physical 15882624 WDR77 Affinity Capture-Western physical 16712789 WDR77 Reconstituted Complex physical 16712789 WDR77 Reconstituted Complex physical 16712789 GTF2I Affinity Capture-Western physical 17970752 EZH2 Affinity Capture-Western physical 18453536 SNAI1 Affinity Capture-Western physical 18519590 UBE2I Reconstituted Complex physical 18628979 UBE2I Affinity Capture-Western physical 18628979 CTCF Affinity Capture-Western physical 18662993 CTCF Reconstituted Complex physical 18662993 CTCF Two-hybrid physical 18662993 EZH2 Affinity Capture-Western physical 18931660 EZH2 Affinity Capture-MS physical 20123894 JARID2 Affinity Capture-Western physical 20123894 MTF2 Affinity Capture-Western physical 20123894 EZH1 Affinity Capture-Western physical 19026781 EZH2 Affinity Capture-Western physical 19026781 EZH1 Affinity Capture-Western physical 19026781 EZH2 Affinity Capture-Western physical 19026781 SUZ12 Affinity Capture-Western physical 19026781 EED Affinity Capture-Western physical 19026781 EED Affinity Capture-Western physical 19026781 EZH1 Affinity Capture-Western physical 19026780 EZH2 Affinity Capture-Western physical 19026780 EED Affinity Capture-Western physical 19026780 CREB1 Two-hybrid physical 20211142 EWSR1 Two-hybrid physical 20211142 HIST1H1A Reconstituted Complex physical 16431907 HIST1H1C Reconstituted Complex physical 16431907 EZH2 Affinity Capture-Western physical 18483221 KDM5A Affinity Capture-Western physical 18483221 EED Affinity Capture-Western physical 18483221 EZH2 Affinity Capture-Western physical 18483221 SETD8 Co-purification physical 12351676 SIRT1 Affinity Capture-Western physical 15684044 PHF1 Affinity Capture-MS physical 18385154 PHF1 Affinity Capture-Western physical 18285464 EZH2 Affinity Capture-Western physical 18285464 EED Affinity Capture-Western physical 18285464 WT1 Affinity Capture-Western physical 21378168 EZH2 Affinity Capture-Western physical 21378168 EZH2 Affinity Capture-Western physical 21378168 WT1 Affinity Capture-Western physical 21378168 DNMT1 Affinity Capture-Western physical 21378168 PPP1R8 Affinity Capture-Western physical 20671031 USP7 Reconstituted Complex physical 20800574 RARG Affinity Capture-Western physical 20857416 EZH2 Affinity Capture-Western physical 21135039 EZH2 Biochemical Activity physical 21123648 EZH2 Reconstituted Complex physical 21123648