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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ALK (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0007165 signal transduction TAS GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0008283 cell proliferation TAS GO:0016310 phosphorylation IDA GO:0016310 phosphorylation TAS GO:0042981 regulation of apoptosis TAS GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation TAS GO:0048666 neuron development TAS GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS cellular_component GO:0005887 integral to plasma membrane IDA GO:0005887 integral to plasma membrane TAS GO:0016020 membrane IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004704 NF-kappaB-inducing kinase activity TAS GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS GO:0004872 receptor activity IEA GO:0005524 ATP binding IEA

Protein-protein interaction details for ALK (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PTN Reconstituted Complex physical 11278720 SHC1 Affinity Capture-Western physical 11888936 PLCG1 Affinity Capture-Western physical 11888936 JAK3 Affinity Capture-Western physical 11850821 SHC3 Affinity Capture-Western physical 12185581 RAB35 Affinity Capture-MS physical 14968112 HSPD1 Affinity Capture-MS physical 14968112 MAP3K4 Affinity Capture-MS physical 14968112 DYT10 Affinity Capture-MS physical 14968112 GRB2 Affinity Capture-MS physical 14968112 SOCS1 Affinity Capture-MS physical 14968112 PIK3CB Affinity Capture-MS physical 14968112 RAD17 Affinity Capture-MS physical 14968112 IRF7 Affinity Capture-MS physical 14968112 EPHB2 Affinity Capture-MS physical 14968112 EIF4B Affinity Capture-MS physical 14968112 MAPK8IP3 Affinity Capture-MS physical 14968112 CENPF Affinity Capture-MS physical 14968112 PLCB2 Affinity Capture-MS physical 14968112 PDX1 Affinity Capture-MS physical 14968112 STAT3 Affinity Capture-MS physical 14968112 MYBPC3 Affinity Capture-MS physical 14968112 MAP2K7 Affinity Capture-MS physical 14968112 JAK2 Affinity Capture-MS physical 14968112 MAP3K5 Affinity Capture-MS physical 14968112 MEP1B Affinity Capture-MS physical 14968112 GAK Affinity Capture-MS physical 14968112 EPHA1 Affinity Capture-MS physical 14968112 UBASH3A Affinity Capture-MS physical 14968112 JAK3 Affinity Capture-MS physical 14968112 MTIF2 Affinity Capture-MS physical 14968112 MYLK Affinity Capture-MS physical 14968112 MAP3K1 Affinity Capture-MS physical 14968112 MAPK1 Affinity Capture-MS physical 14968112 SOCS5 Affinity Capture-MS physical 14968112 CDK13 Affinity Capture-MS physical 14968112 SMC6 Affinity Capture-MS physical 14968112 IRS4 Affinity Capture-MS physical 14968112 KRT18 Affinity Capture-MS physical 14968112 KRT74 Affinity Capture-MS physical 14968112 PLCG1 Affinity Capture-MS physical 14968112 PLCG1 Affinity Capture-Western physical 14968112 EPHA1 Affinity Capture-Western physical 14968112 MAP3K1 Affinity Capture-Western physical 14968112 GRB2 Affinity Capture-Western physical 14968112 HSPD1 Affinity Capture-Western physical 14968112 STAT3 Affinity Capture-Western physical 14968112 IRS1 Affinity Capture-Western physical 14968112 IKBKG Reconstituted Complex physical 20098747 ZC3HC1 Reconstituted Complex physical 12748172 ZC3HC1 Affinity Capture-Western physical 12748172 ZC3HC1 Biochemical Activity physical 12748172