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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FXN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006119 oxidative phosphorylation IEA GO:0006783 heme biosynthetic process NAS GO:0006811 ion transport IEA GO:0006879 cellular iron ion homeostasis IEA GO:0006879 cellular iron ion homeostasis IMP GO:0007005 mitochondrion organization IEA GO:0007628 adult walking behavior IEA GO:0008284 positive regulation of cell proliferation IMP GO:0009060 aerobic respiration IEA GO:0009792 embryo development ending in birth or egg hatching IEA GO:0010039 response to iron ion IMP GO:0010722 regulation of ferrochelatase activity IDA GO:0014070 response to organic cyclic compound IEA GO:0016226 iron-sulfur cluster assembly IEA GO:0016540 protein autoprocessing IDA GO:0018283 iron incorporation into metallo-sulfur cluster IDA GO:0019230 proprioception IEA GO:0030307 positive regulation of cell growth IMP GO:0040015 negative regulation of multicellular organism growth IEA GO:0042493 response to drug IEA GO:0043066 negative regulation of apoptosis IMP GO:0045773 positive regulation of axon extension IEA GO:0046621 negative regulation of organ growth IEA GO:0048554 positive regulation of metalloenzyme activity IMP GO:0051347 positive regulation of transferase activity IMP GO:0051349 positive regulation of lyase activity IDA GO:0051349 positive regulation of lyase activity IMP GO:0051353 positive regulation of oxidoreductase activity IMP GO:0055114 oxidation-reduction process IEA GO:0070301 cellular response to hydrogen peroxide IDA GO:0090201 negative regulation of release of cytochrome c from mitochondria IMP cellular_component GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IDA GO:0005739 mitochondrion IEA GO:0005759 mitochondrial matrix ISS GO:0005759 mitochondrial matrix NAS GO:0005829 cytosol IDA molecular_function GO:0004322 ferroxidase activity IDA GO:0004322 ferroxidase activity IEA GO:0005515 protein binding IPI GO:0008198 ferrous iron binding IDA GO:0008199 ferric iron binding IDA GO:0019899 enzyme binding IEA GO:0034986 iron chaperone activity IDA GO:0046872 metal ion binding IEA GO:0051536 iron-sulfur cluster binding IDA GO:0051537 2 iron, 2 sulfur cluster binding IDA

Protein-protein interaction details for FXN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PMPCB Two-hybrid physical 9700204 PMPCB Reconstituted Complex physical 9700204