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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Irs1 (
Rattus norvegicus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0002053
positive regulation of mesenchymal cell proliferation
IEA
GO:0002053
positive regulation of mesenchymal cell proliferation
ISO
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
IMP
GO:0008286
insulin receptor signaling pathway
IDA
GO:0008286
insulin receptor signaling pathway
ISO
GO:0010468
regulation of gene expression
IEA
GO:0010468
regulation of gene expression
ISO
GO:0010907
positive regulation of glucose metabolic process
IEA
GO:0010907
positive regulation of glucose metabolic process
ISO
GO:0014065
phosphatidylinositol 3-kinase cascade
IEA
GO:0014065
phosphatidylinositol 3-kinase cascade
ISO
GO:0016042
lipid catabolic process
IEA
GO:0016042
lipid catabolic process
ISO
GO:0030073
insulin secretion
ISO
GO:0030335
positive regulation of cell migration
IEA
GO:0030335
positive regulation of cell migration
ISO
GO:0030879
mammary gland development
IEA
GO:0030879
mammary gland development
ISO
GO:0032000
positive regulation of fatty acid beta-oxidation
IEA
GO:0032000
positive regulation of fatty acid beta-oxidation
ISO
GO:0032868
response to insulin stimulus
ISO
GO:0032869
cellular response to insulin stimulus
ISO
GO:0034504
protein localization to nucleus
ISO
GO:0042327
positive regulation of phosphorylation
IDA
GO:0043434
response to peptide hormone stimulus
IDA
GO:0043491
protein kinase B signaling cascade
ISO
GO:0043552
positive regulation of phosphatidylinositol 3-kinase activity
IDA
GO:0043552
positive regulation of phosphatidylinositol 3-kinase activity
ISO
GO:0045725
positive regulation of glycogen biosynthetic process
IEA
GO:0045725
positive regulation of glycogen biosynthetic process
ISO
GO:0046326
positive regulation of glucose import
IEA
GO:0046326
positive regulation of glucose import
ISO
GO:0046627
negative regulation of insulin receptor signaling pathway
IMP
GO:0046628
positive regulation of insulin receptor signaling pathway
IMP
GO:0046676
negative regulation of insulin secretion
IMP
GO:0046676
negative regulation of insulin secretion
ISO
GO:0048009
insulin-like growth factor receptor signaling pathway
IMP
GO:0048009
insulin-like growth factor receptor signaling pathway
ISO
GO:0048009
insulin-like growth factor receptor signaling pathway
ISS
GO:0051291
protein heterooligomerization
IDA
GO:0070094
positive regulation of glucagon secretion
IMP
GO:0090275
negative regulation of somatostatin secretion
IMP
cellular_component
GO:0005634
nucleus
ISO
GO:0005634
nucleus
ISS
GO:0005737
cytoplasm
ISO
GO:0005737
cytoplasm
ISS
GO:0005792
microsome
IDA
GO:0005792
microsome
ISO
GO:0005792
microsome
ISS
GO:0005829
cytosol
IDA
GO:0005829
cytosol
TAS
GO:0005886
plasma membrane
IDA
GO:0005886
plasma membrane
ISO
GO:0005899
insulin receptor complex
IMP
GO:0005901
caveola
IEA
GO:0005901
caveola
ISO
molecular_function
GO:0004871
signal transducer activity
IEA
GO:0005010
insulin-like growth factor-activated receptor activity
IMP
GO:0005068
transmembrane receptor protein tyrosine kinase adaptor activity
IMP
GO:0005080
protein kinase C binding
IPI
GO:0005158
insulin receptor binding
IMP
GO:0005158
insulin receptor binding
ISO
GO:0005158
insulin receptor binding
ISS
GO:0005159
insulin-like growth factor receptor binding
IPI
GO:0005159
insulin-like growth factor receptor binding
ISO
GO:0005159
insulin-like growth factor receptor binding
ISS
GO:0005515
protein binding
IPI
GO:0019901
protein kinase binding
IPI
GO:0019901
protein kinase binding
ISO
GO:0019904
protein domain specific binding
IPI
GO:0042169
SH2 domain binding
IPI
GO:0043548
phosphatidylinositol 3-kinase binding
IDA
GO:0043548
phosphatidylinositol 3-kinase binding
IMP
GO:0043548
phosphatidylinositol 3-kinase binding
IPI
GO:0043548
phosphatidylinositol 3-kinase binding
ISO
Protein-protein interaction details for Irs1 (
Rattus norvegicus
)
(Information is obtained from BioGRID)
Interacting protein
Experiment
Type
PubMed ID
Pik3r2
Affinity Capture-Western
physical
11120660
Pik3r1
Affinity Capture-Western
physical
12594288
Cbl
Affinity Capture-Western
physical
19546233