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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Irs1 (Rattus norvegicus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0002053positive regulation of mesenchymal cell proliferationISO
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIMP
GO:0008286insulin receptor signaling pathwayIDA
GO:0008286insulin receptor signaling pathwayISO
GO:0010468regulation of gene expressionIEA
GO:0010468regulation of gene expressionISO
GO:0010907positive regulation of glucose metabolic processIEA
GO:0010907positive regulation of glucose metabolic processISO
GO:0014065phosphatidylinositol 3-kinase cascadeIEA
GO:0014065phosphatidylinositol 3-kinase cascadeISO
GO:0016042lipid catabolic processIEA
GO:0016042lipid catabolic processISO
GO:0030073insulin secretionISO
GO:0030335positive regulation of cell migrationIEA
GO:0030335positive regulation of cell migrationISO
GO:0030879mammary gland developmentIEA
GO:0030879mammary gland developmentISO
GO:0032000positive regulation of fatty acid beta-oxidationIEA
GO:0032000positive regulation of fatty acid beta-oxidationISO
GO:0032868response to insulin stimulusISO
GO:0032869cellular response to insulin stimulusISO
GO:0034504protein localization to nucleusISO
GO:0042327positive regulation of phosphorylationIDA
GO:0043434response to peptide hormone stimulusIDA
GO:0043491protein kinase B signaling cascadeISO
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityIDA
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityISO
GO:0045725positive regulation of glycogen biosynthetic processIEA
GO:0045725positive regulation of glycogen biosynthetic processISO
GO:0046326positive regulation of glucose importIEA
GO:0046326positive regulation of glucose importISO
GO:0046627negative regulation of insulin receptor signaling pathwayIMP
GO:0046628positive regulation of insulin receptor signaling pathwayIMP
GO:0046676negative regulation of insulin secretionIMP
GO:0046676negative regulation of insulin secretionISO
GO:0048009insulin-like growth factor receptor signaling pathwayIMP
GO:0048009insulin-like growth factor receptor signaling pathwayISO
GO:0048009insulin-like growth factor receptor signaling pathwayISS
GO:0051291protein heterooligomerizationIDA
GO:0070094positive regulation of glucagon secretionIMP
GO:0090275negative regulation of somatostatin secretionIMP
cellular_component
GO:0005634nucleusISO
GO:0005634nucleusISS
GO:0005737cytoplasmISO
GO:0005737cytoplasmISS
GO:0005792microsomeIDA
GO:0005792microsomeISO
GO:0005792microsomeISS
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneISO
GO:0005899insulin receptor complexIMP
GO:0005901caveolaIEA
GO:0005901caveolaISO
molecular_function
GO:0004871signal transducer activityIEA
GO:0005010insulin-like growth factor-activated receptor activityIMP
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activityIMP
GO:0005080protein kinase C bindingIPI
GO:0005158insulin receptor bindingIMP
GO:0005158insulin receptor bindingISO
GO:0005158insulin receptor bindingISS
GO:0005159insulin-like growth factor receptor bindingIPI
GO:0005159insulin-like growth factor receptor bindingISO
GO:0005159insulin-like growth factor receptor bindingISS
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0019901protein kinase bindingISO
GO:0019904protein domain specific bindingIPI
GO:0042169SH2 domain bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingIDA
GO:0043548phosphatidylinositol 3-kinase bindingIMP
GO:0043548phosphatidylinositol 3-kinase bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingISO

Protein-protein interaction details for Irs1 (Rattus norvegicus)
(Information is obtained from BioGRID)
Interacting proteinExperimentTypePubMed ID
Pik3r2Affinity Capture-Westernphysical11120660
Pik3r1Affinity Capture-Westernphysical12594288
CblAffinity Capture-Westernphysical19546233