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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MSH6 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000710 meiotic mismatch repair IBA GO:0000710 meiotic mismatch repair ISS GO:0006200 ATP catabolic process IDA GO:0006281 DNA repair IDA GO:0006298 mismatch repair IDA GO:0006298 mismatch repair IEA GO:0006298 mismatch repair IMP GO:0007131 reciprocal meiotic recombination IBA GO:0008340 determination of adult lifespan IEA GO:0008340 determination of adult lifespan ISS GO:0008629 induction of apoptosis by intracellular signals ISS GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis IBA GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis IEA GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis ISS GO:0009411 response to UV IBA GO:0009411 response to UV IEA GO:0009411 response to UV ISS GO:0016446 somatic hypermutation of immunoglobulin genes IBA GO:0016446 somatic hypermutation of immunoglobulin genes IEA GO:0016446 somatic hypermutation of immunoglobulin genes ISS GO:0016447 somatic recombination of immunoglobulin gene segments IEA GO:0016447 somatic recombination of immunoglobulin gene segments ISS GO:0043570 maintenance of DNA repeat elements IMP GO:0045190 isotype switching IBA GO:0045190 isotype switching IEA GO:0045190 isotype switching ISS GO:0045910 negative regulation of DNA recombination IDA GO:0045910 negative regulation of DNA recombination IEA GO:0051096 positive regulation of helicase activity IDA cellular_component GO:0000228 nuclear chromosome IBA GO:0000790 nuclear chromatin IEA GO:0005634 nucleus IEA GO:0032301 MutSalpha complex IDA GO:0032301 MutSalpha complex IEA molecular_function GO:0000166 nucleotide binding IEA GO:0000287 magnesium ion binding IDA GO:0000400 four-way junction DNA binding IDA GO:0003677 DNA binding IEA GO:0003682 chromatin binding IEA GO:0003684 damaged DNA binding IEA GO:0003690 double-stranded DNA binding IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0005524 ATP binding IEA GO:0008094 DNA-dependent ATPase activity IBA GO:0016887 ATPase activity IDA GO:0030983 mismatched DNA binding IDA GO:0030983 mismatched DNA binding IEA GO:0032137 guanine/thymine mispair binding IDA GO:0032137 guanine/thymine mispair binding IEA GO:0032142 single guanine insertion binding IDA GO:0032143 single thymine insertion binding IDA GO:0032357 oxidized purine DNA binding IDA GO:0032405 MutLalpha complex binding IDA GO:0042803 protein homodimerization activity IPI GO:0043531 ADP binding IDA

Protein-protein interaction details for MSH6 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BRCA1 Two-hybrid physical 11498787 CASP4 Affinity Capture-MS physical 17353931 MYC Affinity Capture-MS physical 17353931 BRCA1 Reconstituted Complex physical 11498787 BLM Co-purification physical 10783165 ATM Co-purification physical 10783165 MLH1 Co-purification physical 10783165 BARD1 Reconstituted Complex physical 11498787 BRCA1 Co-purification physical 10783165 MRE11A Co-purification physical 10783165 MSH2 Co-purification physical 10783165 NBN Co-purification physical 10783165 RAD50 Co-purification physical 10783165 RFC1 Co-purification physical 10783165 MSH2 Affinity Capture-MS physical 14657349 SMC1A Reconstituted Complex physical 14657349 MSH2 Reconstituted Complex physical 9774676 PCNA Far Western physical 11274057 PCNA Affinity Capture-Western physical 11274057 PCNA Protein-peptide physical 11005803 PCNA Affinity Capture-MS physical 12171929 MSH2 Reconstituted Complex physical 10029069 MSH2 Reconstituted Complex physical 10029069 MSH2 Reconstituted Complex physical 8942985 PMS2 Affinity Capture-MS physical 17148452 AIRE Affinity Capture-MS physical 20085707 ATR Affinity Capture-Western physical 20029092 TOPBP1 Affinity Capture-Western physical 20029092 CLSPN Affinity Capture-Western physical 20029092 CHEK1 Affinity Capture-Western physical 20029092 ATR Affinity Capture-Western physical 20029092 CLSPN Affinity Capture-Western physical 20029092 TOPBP1 Affinity Capture-Western physical 20029092 CHEK1 Affinity Capture-Western physical 20029092 UBC Affinity Capture-Western physical 15808853 UBC Affinity Capture-Western physical 15808853 PRKCZ Affinity Capture-Western physical 15808853 BRCA1 Affinity Capture-MS physical 16260778 ESR1 Affinity Capture-MS physical 16260778 MORF4L1 Affinity Capture-MS physical 19553677 MYC Affinity Capture-MS physical 17314511 EP300 Affinity Capture-MS physical 16051665 CREBBP Affinity Capture-MS physical 16051665 BARD1 Co-purification physical 16391231 SUMO1 Reconstituted Complex physical 19596686 UBC Affinity Capture-MS physical 22108332 UBC Affinity Capture-MS physical 21987572 PCNA Affinity Capture-Western physical 21725088 DTL Affinity Capture-Western physical 21725088