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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Lrp6 (Rattus norvegicus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001702gastrulation with mouth forming secondIBA
GO:0001702gastrulation with mouth forming secondISO
GO:0001756somitogenesisISO
GO:0001843neural tube closureIBA
GO:0001843neural tube closureISO
GO:0001933negative regulation of protein phosphorylationIEA
GO:0001933negative regulation of protein phosphorylationISO
GO:0001947heart loopingIEA
GO:0001947heart loopingISO
GO:0002009morphogenesis of an epitheliumISO
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0002053positive regulation of mesenchymal cell proliferationISO
GO:0003344pericardium morphogenesisIBA
GO:0003344pericardium morphogenesisISO
GO:0003401axis elongationISO
GO:0006355regulation of transcription, DNA-dependentIMP
GO:0006469negative regulation of protein kinase activityISO
GO:0007204elevation of cytosolic calcium ion concentrationIMP
GO:0007268synaptic transmissionIMP
GO:0009880embryonic pattern specificationIBA
GO:0009880embryonic pattern specificationISO
GO:0009950dorsal/ventral axis specificationISO
GO:0009952anterior/posterior pattern specificationIBA
GO:0009952anterior/posterior pattern specificationISO
GO:0014029neural crest formationIBA
GO:0014029neural crest formationISO
GO:0014033neural crest cell differentiationIBA
GO:0014033neural crest cell differentiationISO
GO:0016055Wnt receptor signaling pathwayISO
GO:0016337cell-cell adhesionIMP
GO:0021587cerebellum morphogenesisIBA
GO:0021587cerebellum morphogenesisISO
GO:0021794thalamus developmentIBA
GO:0021794thalamus developmentISO
GO:0021795cerebral cortex cell migrationIEA
GO:0021795cerebral cortex cell migrationISO
GO:0021861forebrain radial glial cell differentiationIEA
GO:0021861forebrain radial glial cell differentiationISO
GO:0021872forebrain generation of neuronsISO
GO:0021874Wnt receptor signaling pathway involved in forebrain neuroblast divisionIEA
GO:0021874Wnt receptor signaling pathway involved in forebrain neuroblast divisionISO
GO:0021915neural tube developmentIEA
GO:0021915neural tube developmentISO
GO:0021943formation of radial glial scaffoldsIEA
GO:0021943formation of radial glial scaffoldsISO
GO:0021987cerebral cortex developmentIBA
GO:0021987cerebral cortex developmentISO
GO:0030178negative regulation of Wnt receptor signaling pathwayISO
GO:0030278regulation of ossificationIBA
GO:0030326embryonic limb morphogenesisIBA
GO:0030326embryonic limb morphogenesisISO
GO:0030900forebrain developmentISO
GO:0030901midbrain developmentIBA
GO:0030901midbrain developmentISO
GO:0030917midbrain-hindbrain boundary developmentIBA
GO:0030917midbrain-hindbrain boundary developmentISO
GO:0034392negative regulation of smooth muscle cell apoptosisIEA
GO:0034392negative regulation of smooth muscle cell apoptosisISO
GO:0035108limb morphogenesisISO
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035115embryonic forelimb morphogenesisISO
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisISO
GO:0035121tail morphogenesisIBA
GO:0035121tail morphogenesisISO
GO:0035261external genitalia morphogenesisIBA
GO:0035261external genitalia morphogenesisISO
GO:0042074cell migration involved in gastrulationIEA
GO:0042074cell migration involved in gastrulationISO
GO:0042127regulation of cell proliferationIEA
GO:0042127regulation of cell proliferationISO
GO:0042475odontogenesis of dentine-containing toothIBA
GO:0042475odontogenesis of dentine-containing toothISO
GO:0042733embryonic digit morphogenesisIEA
GO:0042733embryonic digit morphogenesisISO
GO:0043065positive regulation of apoptosisIEA
GO:0043065positive regulation of apoptosisISO
GO:0043434response to peptide hormone stimulusIEP
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIBA
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationISO
GO:0045598regulation of fat cell differentiationIBA
GO:0045599negative regulation of fat cell differentiationIEA
GO:0045599negative regulation of fat cell differentiationISO
GO:0045778positive regulation of ossificationIEA
GO:0045778positive regulation of ossificationISO
GO:0045780positive regulation of bone resorptionIEA
GO:0045780positive regulation of bone resorptionISO
GO:0045787positive regulation of cell cycleIEA
GO:0045787positive regulation of cell cycleISO
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIBA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046849bone remodelingIBA
GO:0046849bone remodelingISO
GO:0048596embryonic camera-type eye morphogenesisIBA
GO:0048596embryonic camera-type eye morphogenesisISO
GO:0048699generation of neuronsISO
GO:0048705skeletal system morphogenesisISO
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0050680negative regulation of epithelial cell proliferationISO
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIBA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISO
GO:0051593response to folic acidIEA
GO:0051593response to folic acidISO
GO:0060021palate developmentIBA
GO:0060021palate developmentISO
GO:0060026convergent extensionIBA
GO:0060026convergent extensionISO
GO:0060042retina morphogenesis in camera-type eyeISO
GO:0060059embryonic retina morphogenesis in camera-type eyeIBA
GO:0060059embryonic retina morphogenesis in camera-type eyeISO
GO:0060070canonical Wnt receptor signaling pathwayIMP
GO:0060070canonical Wnt receptor signaling pathwayISO
GO:0060284regulation of cell developmentIEA
GO:0060284regulation of cell developmentISO
GO:0060325face morphogenesisIBA
GO:0060325face morphogenesisISO
GO:0060349bone morphogenesisIBA
GO:0060349bone morphogenesisISO
GO:0060444branching involved in mammary gland duct morphogenesisIBA
GO:0060444branching involved in mammary gland duct morphogenesisISO
GO:0060535trachea cartilage morphogenesisIBA
GO:0060535trachea cartilage morphogenesisISO
GO:0060596mammary placode formationIEA
GO:0060596mammary placode formationISO
GO:0060603mammary gland duct morphogenesisISO
GO:0061310canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentIEA
GO:0061310canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentISO
GO:0061324canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationIEA
GO:0061324canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationISO
GO:0071397cellular response to cholesterolIEA
GO:0071397cellular response to cholesterolISO
GO:0071542dopaminergic neuron differentiationIEA
GO:0071542dopaminergic neuron differentiationISO
GO:0071901negative regulation of protein serine/threonine kinase activityIEA
GO:0071901negative regulation of protein serine/threonine kinase activityISO
GO:0090009primitive streak formationIBA
GO:0090009primitive streak formationISO
GO:0090118receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIBA
GO:0090118receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportISO
GO:0090244Wnt receptor signaling pathway involved in somitogenesisIBA
GO:0090244Wnt receptor signaling pathway involved in somitogenesisISO
GO:0090245axis elongation involved in somitogenesisIBA
GO:0090245axis elongation involved in somitogenesisISO
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayIEA
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayISO
GO:2000051negative regulation of non-canonical Wnt receptor signaling pathwayISO
GO:2000055positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIEA
GO:2000055positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specificationISO
GO:2000149negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisIEA
GO:2000149negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisISO
GO:2000151negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisIEA
GO:2000151negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisISO
GO:2000162negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisIEA
GO:2000162negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisISO
GO:2000164negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisIEA
GO:2000164negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisISO
GO:2000166negative regulation of planar cell polarity pathway involved in pericardium morphogenesisIEA
GO:2000166negative regulation of planar cell polarity pathway involved in pericardium morphogenesisISO
GO:2000168negative regulation of planar cell polarity pathway involved in neural tube closureIEA
GO:2000168negative regulation of planar cell polarity pathway involved in neural tube closureISO
cellular_component
GO:0005624membrane fractionIEA
GO:0005624membrane fractionISO
GO:0005769early endosomeIEA
GO:0005769early endosomeISO
GO:0005886plasma membraneIBA
GO:0005886plasma membraneISO
GO:0005901caveolaIBA
GO:0005901caveolaISO
GO:0009986cell surfaceIBA
GO:0009986cell surfaceISO
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0031410cytoplasmic vesicleIEA
GO:0031410cytoplasmic vesicleISO
GO:0043025neuronal cell bodyIDA
GO:0043235receptor complexIBA
GO:0045202synapseIDA
molecular_function
GO:0003674molecular_functionND
GO:0005041low-density lipoprotein receptor activityIBA
GO:0005041low-density lipoprotein receptor activityISO
GO:0005102receptor bindingIEA
GO:0005102receptor bindingISO
GO:0005109frizzled bindingIEA
GO:0005109frizzled bindingISO
GO:0015026coreceptor activityIBA
GO:0017147Wnt-protein bindingIBA
GO:0017147Wnt-protein bindingISO
GO:0019210kinase inhibitor activityIEA
GO:0019210kinase inhibitor activityISO
GO:0019534toxin transporter activityIEA
GO:0019534toxin transporter activityISO
GO:0034185apolipoprotein bindingIBA
GO:0034185apolipoprotein bindingISO
GO:0042803protein homodimerization activityIEA
GO:0042803protein homodimerization activityISO
GO:0042813Wnt-activated receptor activityIBA
GO:0071936coreceptor activity involved in Wnt receptor signaling pathwayISO

Protein-protein interaction details for Lrp6 (Rattus norvegicus)
(Information is obtained from BioGRID)
Interacting proteinExperimentTypePubMed ID
Wnt3aPhenotypic Suppressiongenetic15143170