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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HMGCR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006695 cholesterol biosynthetic process IEA GO:0006695 cholesterol biosynthetic process TAS GO:0007568 aging IEA GO:0007584 response to nutrient IEA GO:0008299 isoprenoid biosynthetic process IEA GO:0008354 germ cell migration TAS GO:0008406 gonad development TAS GO:0008542 visual learning IEA GO:0009790 embryo development IEA GO:0015936 coenzyme A metabolic process IEA GO:0043407 negative regulation of MAP kinase activity IEA GO:0048643 positive regulation of skeletal muscle tissue development IEA GO:0055114 oxidation-reduction process IEA cellular_component GO:0005777 peroxisome IEA GO:0005778 peroxisomal membrane IEA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005789 endoplasmic reticulum membrane TAS GO:0005792 microsome IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA molecular_function GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity TAS GO:0016491 oxidoreductase activity IEA GO:0042282 hydroxymethylglutaryl-CoA reductase activity IEA GO:0042803 protein homodimerization activity IEA GO:0050661 NADP binding IEA GO:0050662 coenzyme binding IEA

Protein-protein interaction details for HMGCR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID STARD13 Two-hybrid physical 14697242 UBC Affinity Capture-Western physical 17681147 INSIG1 Affinity Capture-Western physical 16168377 UBC Affinity Capture-Western physical 15090540 UBC Affinity Capture-Western physical 14563840 UBC Affinity Capture-Western physical 19458199 INSIG1 Affinity Capture-Western physical 19458199 UBC Affinity Capture-MS physical 16196087 INSIG1 Affinity Capture-Western physical 20458442 UBC Affinity Capture-Western physical 20458442 AMFR Affinity Capture-Western physical 21343306 UBC Affinity Capture-Western physical 21343306 ERLIN2 Affinity Capture-Western physical 21343306 AMFR Affinity Capture-Western physical 21343306 VCP Affinity Capture-Western physical 21343306 RNF139 Affinity Capture-Western physical 22143767 UBC Affinity Capture-Western physical 22143767 UBC Affinity Capture-MS physical 21987572