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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IFNG (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000060 protein import into nucleus, translocation IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0001781 neutrophil apoptosis IEA GO:0002026 regulation of the force of heart contraction IEA GO:0002053 positive regulation of mesenchymal cell proliferation ISS GO:0002250 adaptive immune response IEA GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response IEA GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS GO:0006925 inflammatory cell apoptosis IEA GO:0006928 cellular component movement TAS GO:0006959 humoral immune response IEA GO:0007050 cell cycle arrest IDA GO:0007166 cell surface receptor linked signaling pathway TAS GO:0009615 response to virus IDA GO:0019221 cytokine-mediated signaling pathway TAS GO:0019882 antigen processing and presentation IEA GO:0030593 neutrophil chemotaxis IEA GO:0030968 endoplasmic reticulum unfolded protein response IEA GO:0031642 negative regulation of myelination IEA GO:0032224 positive regulation of synaptic transmission, cholinergic IEA GO:0032700 negative regulation of interleukin-17 production IDA GO:0032735 positive regulation of interleukin-12 production IDA GO:0032747 positive regulation of interleukin-23 production IDA GO:0032760 positive regulation of tumor necrosis factor production IEA GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IDA GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein NAS GO:0034393 positive regulation of smooth muscle cell apoptosis IDA GO:0040008 regulation of growth IEA GO:0042102 positive regulation of T cell proliferation IEA GO:0042493 response to drug IEA GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein IDA GO:0042742 defense response to bacterium IEA GO:0042832 defense response to protozoan IEA GO:0044130 negative regulation of growth of symbiont in host IEA GO:0045080 positive regulation of chemokine biosynthetic process IEA GO:0045084 positive regulation of interleukin-12 biosynthetic process IEA GO:0045348 positive regulation of MHC class II biosynthetic process IEA GO:0045410 positive regulation of interleukin-6 biosynthetic process IEA GO:0045429 positive regulation of nitric oxide biosynthetic process IDA GO:0045666 positive regulation of neuron differentiation IEA GO:0045672 positive regulation of osteoclast differentiation IDA GO:0045785 positive regulation of cell adhesion IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA GO:0048662 negative regulation of smooth muscle cell proliferation IDA GO:0050718 positive regulation of interleukin-1 beta secretion IEA GO:0050776 regulation of immune response IEA GO:0050796 regulation of insulin secretion IDA GO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA GO:0051712 positive regulation of killing of cells of other organism IDA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity IDA GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process IDA GO:0060557 positive regulation of vitamin D biosynthetic process IDA GO:0060559 positive regulation of calcidiol 1-monooxygenase activity IDA GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation ISS GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA cellular_component GO:0005576 extracellular region TAS GO:0005615 extracellular space IEA molecular_function GO:0005125 cytokine activity IEA GO:0005133 interferon-gamma receptor binding IEA

Protein-protein interaction details for IFNG (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IFNG Co-crystal Structure physical 10986460 IFNGR1 Co-crystal Structure physical 10986460 IFNGR1 Reconstituted Complex physical 7673114 IFNGR2 Reconstituted Complex physical 7673114