Database of mammalian genes
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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for APOE (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000302
response to reactive oxygen species
NAS
GO:0001937
negative regulation of endothelial cell proliferation
IDA
GO:0002021
response to dietary excess
IEA
GO:0006629
lipid metabolic process
IEA
GO:0006629
lipid metabolic process
TAS
GO:0006641
triglyceride metabolic process
IDA
GO:0006641
triglyceride metabolic process
IMP
GO:0006707
cholesterol catabolic process
IEA
GO:0006874
cellular calcium ion homeostasis
IEA
GO:0006898
receptor-mediated endocytosis
IDA
GO:0006916
anti-apoptosis
IDA
GO:0006917
induction of apoptosis
IDA
GO:0006979
response to oxidative stress
IEA
GO:0007010
cytoskeleton organization
TAS
GO:0007186
G-protein coupled receptor protein signaling pathway
IDA
GO:0007263
nitric oxide mediated signal transduction
IDA
GO:0007271
synaptic transmission, cholinergic
TAS
GO:0007568
aging
IEA
GO:0008203
cholesterol metabolic process
IDA
GO:0008203
cholesterol metabolic process
IMP
GO:0008219
cell death
IEA
GO:0010468
regulation of gene expression
IEA
GO:0010544
negative regulation of platelet activation
IDA
GO:0010873
positive regulation of cholesterol esterification
IDA
GO:0010873
positive regulation of cholesterol esterification
IEA
GO:0010875
positive regulation of cholesterol efflux
IDA
GO:0010875
positive regulation of cholesterol efflux
IGI
GO:0014012
peripheral nervous system axon regeneration
IEA
GO:0019934
cGMP-mediated signaling
IDA
GO:0030195
negative regulation of blood coagulation
IDA
GO:0030516
regulation of axon extension
TAS
GO:0030828
positive regulation of cGMP biosynthetic process
IDA
GO:0032488
Cdc42 protein signal transduction
IDA
GO:0032805
positive regulation of low-density lipoprotein particle receptor catabolic process
IDA
GO:0033344
cholesterol efflux
IDA
GO:0033344
cholesterol efflux
IEA
GO:0033700
phospholipid efflux
IDA
GO:0034372
very-low-density lipoprotein particle remodeling
IDA
GO:0034372
very-low-density lipoprotein particle remodeling
IEA
GO:0034372
very-low-density lipoprotein particle remodeling
IGI
GO:0034374
low-density lipoprotein particle remodeling
IEA
GO:0034375
high-density lipoprotein particle remodeling
IGI
GO:0034380
high-density lipoprotein particle assembly
IDA
GO:0034382
chylomicron remnant clearance
IMP
GO:0034384
high-density lipoprotein particle clearance
IDA
GO:0034447
very-low-density lipoprotein particle clearance
IDA
GO:0034447
very-low-density lipoprotein particle clearance
IMP
GO:0042157
lipoprotein metabolic process
TAS
GO:0042158
lipoprotein biosynthetic process
IEA
GO:0042159
lipoprotein catabolic process
IEA
GO:0042311
vasodilation
IEA
GO:0042632
cholesterol homeostasis
IDA
GO:0042632
cholesterol homeostasis
IEA
GO:0043407
negative regulation of MAP kinase activity
IDA
GO:0043537
negative regulation of blood vessel endothelial cell migration
IDA
GO:0043691
reverse cholesterol transport
IDA
GO:0045471
response to ethanol
IEA
GO:0045541
negative regulation of cholesterol biosynthetic process
IDA
GO:0046907
intracellular transport
TAS
GO:0048168
regulation of neuronal synaptic plasticity
TAS
GO:0048844
artery morphogenesis
IEA
GO:0050728
negative regulation of inflammatory response
IC
GO:0051000
positive regulation of nitric-oxide synthase activity
IDA
GO:0051044
positive regulation of membrane protein ectodomain proteolysis
IDA
GO:0051651
maintenance of location in cell
IEA
GO:0055088
lipid homeostasis
IEA
GO:0071363
cellular response to growth factor stimulus
IEA
GO:0072358
cardiovascular system development
IEA
cellular_component
GO:0005576
extracellular region
IEA
GO:0005576
extracellular region
TAS
GO:0005615
extracellular space
IDA
GO:0005615
extracellular space
IEA
GO:0005737
cytoplasm
IEA
GO:0005737
cytoplasm
NAS
GO:0005737
cytoplasm
TAS
GO:0005769
early endosome
IEA
GO:0005770
late endosome
IEA
GO:0005794
Golgi apparatus
IEA
GO:0005874
microtubule
IEA
GO:0005886
plasma membrane
TAS
GO:0030425
dendrite
IEA
GO:0030425
dendrite
NAS
GO:0031232
extrinsic to external side of plasma membrane
IEA
GO:0034361
very-low-density lipoprotein particle
IDA
GO:0034362
low-density lipoprotein particle
IDA
GO:0034362
low-density lipoprotein particle
IEA
GO:0034363
intermediate-density lipoprotein particle
IDA
GO:0034364
high-density lipoprotein particle
IDA
GO:0042627
chylomicron
IDA
GO:0043025
neuronal cell body
IEA
GO:0043025
neuronal cell body
NAS
molecular_function
GO:0001540
beta-amyloid binding
IDA
GO:0005319
lipid transporter activity
IDA
GO:0005319
lipid transporter activity
IEA
GO:0005515
protein binding
IPI
GO:0005543
phospholipid binding
IDA
GO:0005543
phospholipid binding
IEA
GO:0008201
heparin binding
IDA
GO:0008289
lipid binding
IDA
GO:0016209
antioxidant activity
IDA
GO:0017127
cholesterol transporter activity
IEA
GO:0042802
identical protein binding
IDA
GO:0042803
protein homodimerization activity
IDA
GO:0046911
metal chelating activity
IDA
GO:0046982
protein heterodimerization activity
IPI
GO:0048156
tau protein binding
IPI
GO:0050750
low-density lipoprotein particle receptor binding
IDA
GO:0050750
low-density lipoprotein particle receptor binding
IPI
GO:0060228
phosphatidylcholine-sterol O-acyltransferase activator activity
IDA
GO:0060228
phosphatidylcholine-sterol O-acyltransferase activator activity
IEA
GO:0070326
very-low-density lipoprotein particle receptor binding
IDA
GO:0070326
very-low-density lipoprotein particle receptor binding
IPI
GO:0071813
lipoprotein particle binding
IEA
Protein-protein interaction details for APOE (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
LRP8
Reconstituted Complex
physical
12950167
PLTP
Affinity Capture-Western
physical
12810820
LRP2
Reconstituted Complex
physical
7768901
A2M
Affinity Capture-Western
physical
9831625
A2M
Reconstituted Complex
physical
9831625
MAPT
Reconstituted Complex
physical
8620924
NEFM
Reconstituted Complex
physical
8620924
UBC
Affinity Capture-Western
physical
11401504