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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for APOE (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000302response to reactive oxygen speciesNAS
GO:0001937negative regulation of endothelial cell proliferationIDA
GO:0002021response to dietary excessIEA
GO:0006629lipid metabolic processIEA
GO:0006629lipid metabolic processTAS
GO:0006641triglyceride metabolic processIDA
GO:0006641triglyceride metabolic processIMP
GO:0006707cholesterol catabolic processIEA
GO:0006874cellular calcium ion homeostasisIEA
GO:0006898receptor-mediated endocytosisIDA
GO:0006916anti-apoptosisIDA
GO:0006917induction of apoptosisIDA
GO:0006979response to oxidative stressIEA
GO:0007010cytoskeleton organizationTAS
GO:0007186G-protein coupled receptor protein signaling pathwayIDA
GO:0007263nitric oxide mediated signal transductionIDA
GO:0007271synaptic transmission, cholinergicTAS
GO:0007568agingIEA
GO:0008203cholesterol metabolic processIDA
GO:0008203cholesterol metabolic processIMP
GO:0008219cell deathIEA
GO:0010468regulation of gene expressionIEA
GO:0010544negative regulation of platelet activationIDA
GO:0010873positive regulation of cholesterol esterificationIDA
GO:0010873positive regulation of cholesterol esterificationIEA
GO:0010875positive regulation of cholesterol effluxIDA
GO:0010875positive regulation of cholesterol effluxIGI
GO:0014012peripheral nervous system axon regenerationIEA
GO:0019934cGMP-mediated signalingIDA
GO:0030195negative regulation of blood coagulationIDA
GO:0030516regulation of axon extensionTAS
GO:0030828positive regulation of cGMP biosynthetic processIDA
GO:0032488Cdc42 protein signal transductionIDA
GO:0032805positive regulation of low-density lipoprotein particle receptor catabolic processIDA
GO:0033344cholesterol effluxIDA
GO:0033344cholesterol effluxIEA
GO:0033700phospholipid effluxIDA
GO:0034372very-low-density lipoprotein particle remodelingIDA
GO:0034372very-low-density lipoprotein particle remodelingIEA
GO:0034372very-low-density lipoprotein particle remodelingIGI
GO:0034374low-density lipoprotein particle remodelingIEA
GO:0034375high-density lipoprotein particle remodelingIGI
GO:0034380high-density lipoprotein particle assemblyIDA
GO:0034382chylomicron remnant clearanceIMP
GO:0034384high-density lipoprotein particle clearanceIDA
GO:0034447very-low-density lipoprotein particle clearanceIDA
GO:0034447very-low-density lipoprotein particle clearanceIMP
GO:0042157lipoprotein metabolic processTAS
GO:0042158lipoprotein biosynthetic processIEA
GO:0042159lipoprotein catabolic processIEA
GO:0042311vasodilationIEA
GO:0042632cholesterol homeostasisIDA
GO:0042632cholesterol homeostasisIEA
GO:0043407negative regulation of MAP kinase activityIDA
GO:0043537negative regulation of blood vessel endothelial cell migrationIDA
GO:0043691reverse cholesterol transportIDA
GO:0045471response to ethanolIEA
GO:0045541negative regulation of cholesterol biosynthetic processIDA
GO:0046907intracellular transportTAS
GO:0048168regulation of neuronal synaptic plasticityTAS
GO:0048844artery morphogenesisIEA
GO:0050728negative regulation of inflammatory responseIC
GO:0051000positive regulation of nitric-oxide synthase activityIDA
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA
GO:0051651maintenance of location in cellIEA
GO:0055088lipid homeostasisIEA
GO:0071363cellular response to growth factor stimulusIEA
GO:0072358cardiovascular system developmentIEA
cellular_component
GO:0005576extracellular regionIEA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
GO:0005737cytoplasmNAS
GO:0005737cytoplasmTAS
GO:0005769early endosomeIEA
GO:0005770late endosomeIEA
GO:0005794Golgi apparatusIEA
GO:0005874microtubuleIEA
GO:0005886plasma membraneTAS
GO:0030425dendriteIEA
GO:0030425dendriteNAS
GO:0031232extrinsic to external side of plasma membraneIEA
GO:0034361very-low-density lipoprotein particleIDA
GO:0034362low-density lipoprotein particleIDA
GO:0034362low-density lipoprotein particleIEA
GO:0034363intermediate-density lipoprotein particleIDA
GO:0034364high-density lipoprotein particleIDA
GO:0042627chylomicronIDA
GO:0043025neuronal cell bodyIEA
GO:0043025neuronal cell bodyNAS
molecular_function
GO:0001540beta-amyloid bindingIDA
GO:0005319lipid transporter activityIDA
GO:0005319lipid transporter activityIEA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIDA
GO:0005543phospholipid bindingIEA
GO:0008201heparin bindingIDA
GO:0008289lipid bindingIDA
GO:0016209antioxidant activityIDA
GO:0017127cholesterol transporter activityIEA
GO:0042802identical protein bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0046911metal chelating activityIDA
GO:0046982protein heterodimerization activityIPI
GO:0048156tau protein bindingIPI
GO:0050750low-density lipoprotein particle receptor bindingIDA
GO:0050750low-density lipoprotein particle receptor bindingIPI
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIEA
GO:0070326very-low-density lipoprotein particle receptor bindingIDA
GO:0070326very-low-density lipoprotein particle receptor bindingIPI
GO:0071813lipoprotein particle bindingIEA

Protein-protein interaction details for APOE (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
LRP8Reconstituted Complexphysical12950167
PLTPAffinity Capture-Westernphysical12810820
LRP2Reconstituted Complexphysical7768901
A2MAffinity Capture-Westernphysical9831625
A2MReconstituted Complexphysical9831625
MAPTReconstituted Complexphysical8620924
NEFMReconstituted Complexphysical8620924
UBCAffinity Capture-Westernphysical11401504