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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FAS (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IEA GO:0002377 immunoglobulin production IEA GO:0003014 renal system process IEA GO:0006461 protein complex assembly TAS GO:0006915 apoptosis IDA GO:0006915 apoptosis IEA GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis TAS GO:0006917 induction of apoptosis TAS GO:0006919 activation of caspase activity TAS GO:0006924 activation-induced cell death of T cells IEA GO:0006925 inflammatory cell apoptosis IEA GO:0006927 transformed cell apoptosis IEA GO:0006955 immune response IEA GO:0007165 signal transduction IEA GO:0007165 signal transduction TAS GO:0007283 spermatogenesis IEA GO:0007568 aging IEA GO:0008624 induction of apoptosis by extracellular signals TAS GO:0008625 induction of apoptosis via death domain receptors IEA GO:0008633 activation of pro-apoptotic gene products TAS GO:0009636 response to toxin IEA GO:0010035 response to inorganic substance IEA GO:0010467 gene expression IEA GO:0010940 positive regulation of necrotic cell death IMP GO:0019724 B cell mediated immunity IEA GO:0031104 dendrite regeneration IEA GO:0032464 positive regulation of protein homooligomerization IEA GO:0032496 response to lipopolysaccharide IEA GO:0034097 response to cytokine stimulus IEA GO:0042127 regulation of cell proliferation IEA GO:0042493 response to drug IEA GO:0042698 ovulation cycle IEA GO:0042981 regulation of apoptosis NAS GO:0043065 positive regulation of apoptosis IMP GO:0043434 response to peptide hormone stimulus IEA GO:0043627 response to estrogen stimulus IEA GO:0045060 negative thymic T cell selection IEA GO:0045619 regulation of lymphocyte differentiation IEA GO:0045637 regulation of myeloid cell differentiation IEA GO:0048536 spleen development IEA GO:0050869 negative regulation of B cell activation IEA GO:0051384 response to glucocorticoid stimulus IEA GO:0051402 neuron apoptosis IEA GO:0070848 response to growth factor stimulus IEA GO:0071260 cellular response to mechanical stimulus IEP GO:0071285 cellular response to lithium ion IEA cellular_component GO:0005576 extracellular region IEA GO:0005625 soluble fraction TAS GO:0005829 cytosol NAS GO:0005886 plasma membrane TAS GO:0009897 external side of plasma membrane IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0031264 death-inducing signaling complex IDA GO:0031265 CD95 death-inducing signaling complex IDA GO:0045121 membrane raft IDA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0004871 signal transducer activity TAS GO:0004872 receptor activity IEA GO:0004872 receptor activity NAS GO:0004888 transmembrane signaling receptor activity IEA GO:0005031 tumor necrosis factor receptor activity IEA GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0019900 kinase binding IPI GO:0042802 identical protein binding IPI

Protein-protein interaction details for FAS (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SUMO1 Two-hybrid physical 8906799 BID Co-purification physical 15659383 TNFRSF10B Co-purification physical 15659383 EZR Co-purification physical 15659383 FADD Co-purification physical 15659383 FASLG Co-purification physical 15659383 MAPK8 Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 RHOA Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 TNFRSF1A Co-purification physical 15659383 FASLG Affinity Capture-Western physical 12887920 C14orf1 Two-hybrid physical 16169070 C1orf103 Two-hybrid physical 16169070 EEF1A1 Two-hybrid physical 16169070 CRMP1 Two-hybrid physical 16169070 FASLG Reconstituted Complex physical 9126929 FAS Two-hybrid physical 7538908 RIPK1 Two-hybrid physical 7538908 CASP10 Affinity Capture-Western physical 9045686 CASP8 Affinity Capture-Western physical 9208847 CFLAR Affinity Capture-Western physical 9208847 PDCD6 Two-hybrid physical 11606059 PDCD6 Affinity Capture-Western physical 11606059 PDCD6 Reconstituted Complex physical 11606059 FADD Affinity Capture-Western physical 9325248 CASP8 Affinity Capture-Western physical 9325248 CASP10 Affinity Capture-Western physical 9325248 CFLAR Affinity Capture-Western physical 9325248 SUMO1 Reconstituted Complex physical 8906799 SUMO1 Two-hybrid physical 11112409 UBE2I Affinity Capture-Western physical 9257699 HIPK3 Affinity Capture-Western physical 11034606 FADD Affinity Capture-Western physical 9082980 FAF1 Affinity Capture-Western physical 8524870 NOL3 Phenotypic Suppression genetic 9560245 FAIM2 Affinity Capture-Western physical 10535980 FYN Affinity Capture-Western physical 8626376 FADD Co-crystal Structure physical 8967952 FADD Reconstituted Complex physical 8967952 FADD Affinity Capture-Western physical 7538907 FADD Reconstituted Complex physical 7538907 FADD Two-hybrid physical 7538907 CASP8AP2 Affinity Capture-Western physical 10235259 TNFSF13 Reconstituted Complex physical 10706119 LCK Reconstituted Complex physical 8864141 FASLG Reconstituted Complex physical 9228058 DAXX Reconstituted Complex physical 11483955 FBF1 Two-hybrid physical 10978533 FADD Two-hybrid physical 12107169 BRE Affinity Capture-Western physical 15465831 BRE Affinity Capture-Western physical 15465831 TNF Affinity Capture-Western physical 12753742 FASLG Affinity Capture-Western physical 12753742 KRIT1 Affinity Capture-Western physical 14594800 KRIT1 Reconstituted Complex physical 14594800