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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FASLG (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006915 apoptosis TAS GO:0006917 induction of apoptosis TAS GO:0006919 activation of caspase activity IGI GO:0006919 activation of caspase activity IMP GO:0006919 activation of caspase activity TAS GO:0006925 inflammatory cell apoptosis IEA GO:0006955 immune response IEA GO:0007165 signal transduction IEA GO:0007267 cell-cell signaling TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008624 induction of apoptosis by extracellular signals IDA GO:0008624 induction of apoptosis by extracellular signals TAS GO:0008625 induction of apoptosis via death domain receptors IEA GO:0008633 activation of pro-apoptotic gene products TAS GO:0016525 negative regulation of angiogenesis IDA GO:0030644 cellular chloride ion homeostasis IEA GO:0032496 response to lipopolysaccharide IEA GO:0033554 cellular response to stress IEA GO:0043065 positive regulation of apoptosis IDA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0043525 positive regulation of neuron apoptosis IEA GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA GO:0046666 retinal cell programmed cell death IEA GO:0048388 endosomal lumen acidification IEA GO:0060554 induction of necroptosis of activated-T cells IDA GO:0060555 induction of necroptosis by extracellular signals IDA GO:0070265 necrotic cell death IDA GO:0070848 response to growth factor stimulus IEA cellular_component GO:0005576 extracellular region TAS GO:0005615 extracellular space IDA GO:0005886 plasma membrane IEA GO:0005887 integral to plasma membrane TAS GO:0005901 caveola IEA GO:0009897 external side of plasma membrane IEA GO:0016023 cytoplasmic membrane-bounded vesicle IEA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0005102 receptor binding TAS GO:0005125 cytokine activity IEA GO:0005164 tumor necrosis factor receptor binding IEA GO:0005515 protein binding IPI

Protein-protein interaction details for FASLG (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SUMO1 Two-hybrid physical 8906799 TNFRSF10B Co-purification physical 15659383 BID Co-purification physical 15659383 EZR Co-purification physical 15659383 FADD Co-purification physical 15659383 FAS Co-purification physical 15659383 MAPK8 Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 RHOA Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 TNFRSF1A Co-purification physical 15659383 FADD Affinity Capture-Western physical 12887920 CASP8 Affinity Capture-Western physical 12887920 FAS Affinity Capture-Western physical 12887920 FNBP1 Affinity Capture-MS physical 12023017 PACSIN2 Affinity Capture-MS physical 12023017 GRB2 Affinity Capture-Western physical 12023017 GRB2 Reconstituted Complex physical 12023017 FNBP1 Reconstituted Complex physical 12023017 PACSIN2 Reconstituted Complex physical 12023017 PACSIN2 Affinity Capture-Western physical 12023017 FNBP1 Affinity Capture-Western physical 12023017 FAS Reconstituted Complex physical 9126929 FN1 Reconstituted Complex physical 11276204 MMP7 Biochemical Activity physical 12464266 TNFRSF6B Affinity Capture-Western physical 10318773 FYN Reconstituted Complex physical 11741599 GRB2 Reconstituted Complex physical 11741599 LCK Reconstituted Complex physical 11741599 GRAP Reconstituted Complex physical 11741599 GRAP2 Reconstituted Complex physical 11741599 NCK1 Reconstituted Complex physical 11741599 EZR Affinity Capture-Western physical 11013215 FAS Reconstituted Complex physical 9228058 FYN Reconstituted Complex physical 7589480 PTPN13 Reconstituted Complex physical 9261095 TNFRSF6B Affinity Capture-Western physical 11994433 TNFRSF6B Affinity Capture-Western physical 9872321 FGR Reconstituted Complex physical 17164290 LYN Reconstituted Complex physical 17164290 FYN Reconstituted Complex physical 17164290 UBC Affinity Capture-Western physical 17164290 TNFRSF1A Affinity Capture-Western physical 12753742 FAS Affinity Capture-Western physical 12753742 FADD Affinity Capture-Western physical 12753742 CASP8 Affinity Capture-Western physical 12753742