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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IL6 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001781neutrophil apoptosisIDA
GO:0001781neutrophil apoptosisIEA
GO:0002384hepatic immune responseIDA
GO:0002384hepatic immune responseTAS
GO:0002446neutrophil mediated immunityIC
GO:0002548monocyte chemotaxisIC
GO:0002675positive regulation of acute inflammatory responseIDA
GO:0002690positive regulation of leukocyte chemotaxisIC
GO:0006469negative regulation of protein kinase activityIEA
GO:0006953acute-phase responseTAS
GO:0006954inflammatory responseIDA
GO:0006955immune responseIEA
GO:0006959humoral immune responseIC
GO:0007568agingIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIMP
GO:0008285negative regulation of cell proliferationIEA
GO:0008360regulation of cell shapeIEA
GO:0009408response to heatIEA
GO:0009409response to coldIEA
GO:0009611response to woundingIEA
GO:0009612response to mechanical stimulusIEA
GO:0009617response to bacteriumIEA
GO:0010574regulation of vascular endothelial growth factor productionIDA
GO:0010888negative regulation of lipid storageNAS
GO:0014070response to organic cyclic compoundIEA
GO:0016049cell growthIEA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030168platelet activationTAS
GO:0031000response to caffeineIEA
GO:0031018endocrine pancreas developmentIEA
GO:0031018endocrine pancreas developmentISS
GO:0031175neuron projection developmentIMP
GO:0031667response to nutrient levelsIEA
GO:0032494response to peptidoglycanIEP
GO:0032496response to lipopolysaccharideIEA
GO:0032722positive regulation of chemokine productionIDA
GO:0032722positive regulation of chemokine productionIMP
GO:0032755positive regulation of interleukin-6 productionIDA
GO:0032868response to insulin stimulusIEA
GO:0032966negative regulation of collagen biosynthetic processIDA
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0033160positive regulation of protein import into nucleus, translocationIEA
GO:0034097response to cytokine stimulusIEA
GO:0042102positive regulation of T cell proliferationIDA
GO:0042493response to drugIEA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIEA
GO:0042832defense response to protozoanIEA
GO:0042981regulation of apoptosisIDA
GO:0042981regulation of apoptosisIEA
GO:0043066negative regulation of apoptosisIDA
GO:0043154negative regulation of caspase activityIEA
GO:0043200response to amino acid stimulusIEA
GO:0043410positive regulation of MAPKKK cascadeIDA
GO:0043526neuroprotectionIEA
GO:0045079negative regulation of chemokine biosynthetic processIEA
GO:0045079negative regulation of chemokine biosynthetic processISS
GO:0045188regulation of circadian sleep/wake cycle, non-REM sleepIEA
GO:0045429positive regulation of nitric oxide biosynthetic processIEA
GO:0045454cell redox homeostasisIEA
GO:0045599negative regulation of fat cell differentiationNAS
GO:0045630positive regulation of T-helper 2 cell differentiationIEA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045669positive regulation of osteoblast differentiationTAS
GO:0045721negative regulation of gluconeogenesisIEA
GO:0045727positive regulation of translationIDA
GO:0045740positive regulation of DNA replicationIEA
GO:0045765regulation of angiogenesisIC
GO:0045768positive regulation of anti-apoptosisIMP
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046427positive regulation of JAK-STAT cascadeIDA
GO:0046427positive regulation of JAK-STAT cascadeIEA
GO:0046677response to antibioticIEA
GO:0046716muscle cell homeostasisIEA
GO:0046849bone remodelingIEA
GO:0046888negative regulation of hormone secretionIEA
GO:0048635negative regulation of muscle organ developmentIEA
GO:0048661positive regulation of smooth muscle cell proliferationIDA
GO:0050679positive regulation of epithelial cell proliferationIEA
GO:0050710negative regulation of cytokine secretionIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050829defense response to Gram-negative bacteriumIEP
GO:0050830defense response to Gram-positive bacteriumIEP
GO:0050871positive regulation of B cell activationIDA
GO:0051024positive regulation of immunoglobulin secretionIDA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051384response to glucocorticoid stimulusIDA
GO:0051592response to calcium ionIEA
GO:0051602response to electrical stimulusIEA
GO:0051607defense response to virusIDA
GO:0051897positive regulation of protein kinase B signaling cascadeIEA
GO:0051971positive regulation of transmission of nerve impulseIEA
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIEA
GO:0070091glucagon secretionIEA
GO:0070091glucagon secretionISS
GO:0070102interleukin-6-mediated signaling pathwayIDA
GO:0070102interleukin-6-mediated signaling pathwayIEA
GO:0070301cellular response to hydrogen peroxideIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEA
GO:2000366positive regulation of STAT protein import into nucleusIC
cellular_component
GO:0005576extracellular regionIEA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceIEA
GO:0005896interleukin-6 receptor complexIDA
GO:0009897external side of plasma membraneIEA
molecular_function
GO:0005125cytokine activityIDA
GO:0005125cytokine activityIEA
GO:0005125cytokine activityNAS
GO:0005138interleukin-6 receptor bindingIEA
GO:0005138interleukin-6 receptor bindingIPI
GO:0005138interleukin-6 receptor bindingNAS
GO:0008083growth factor activityIDA

Protein-protein interaction details for IL6 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
IL6RReconstituted Complexphysical14557255
IL6RReconstituted Complexphysical12643274
SH3GL2Two-hybridphysical16169070
IL6RAffinity Capture-Westernphysical2788034