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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for IL6 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0001781
neutrophil apoptosis
IDA
GO:0001781
neutrophil apoptosis
IEA
GO:0002384
hepatic immune response
IDA
GO:0002384
hepatic immune response
TAS
GO:0002446
neutrophil mediated immunity
IC
GO:0002548
monocyte chemotaxis
IC
GO:0002675
positive regulation of acute inflammatory response
IDA
GO:0002690
positive regulation of leukocyte chemotaxis
IC
GO:0006469
negative regulation of protein kinase activity
IEA
GO:0006953
acute-phase response
TAS
GO:0006954
inflammatory response
IDA
GO:0006955
immune response
IEA
GO:0006959
humoral immune response
IC
GO:0007568
aging
IEA
GO:0008284
positive regulation of cell proliferation
IDA
GO:0008284
positive regulation of cell proliferation
IMP
GO:0008285
negative regulation of cell proliferation
IEA
GO:0008360
regulation of cell shape
IEA
GO:0009408
response to heat
IEA
GO:0009409
response to cold
IEA
GO:0009611
response to wounding
IEA
GO:0009612
response to mechanical stimulus
IEA
GO:0009617
response to bacterium
IEA
GO:0010574
regulation of vascular endothelial growth factor production
IDA
GO:0010888
negative regulation of lipid storage
NAS
GO:0014070
response to organic cyclic compound
IEA
GO:0016049
cell growth
IEA
GO:0019221
cytokine-mediated signaling pathway
IDA
GO:0030168
platelet activation
TAS
GO:0031000
response to caffeine
IEA
GO:0031018
endocrine pancreas development
IEA
GO:0031018
endocrine pancreas development
ISS
GO:0031175
neuron projection development
IMP
GO:0031667
response to nutrient levels
IEA
GO:0032494
response to peptidoglycan
IEP
GO:0032496
response to lipopolysaccharide
IEA
GO:0032722
positive regulation of chemokine production
IDA
GO:0032722
positive regulation of chemokine production
IMP
GO:0032755
positive regulation of interleukin-6 production
IDA
GO:0032868
response to insulin stimulus
IEA
GO:0032966
negative regulation of collagen biosynthetic process
IDA
GO:0033138
positive regulation of peptidyl-serine phosphorylation
IDA
GO:0033160
positive regulation of protein import into nucleus, translocation
IEA
GO:0034097
response to cytokine stimulus
IEA
GO:0042102
positive regulation of T cell proliferation
IDA
GO:0042493
response to drug
IEA
GO:0042517
positive regulation of tyrosine phosphorylation of Stat3 protein
IDA
GO:0042517
positive regulation of tyrosine phosphorylation of Stat3 protein
IEA
GO:0042832
defense response to protozoan
IEA
GO:0042981
regulation of apoptosis
IDA
GO:0042981
regulation of apoptosis
IEA
GO:0043066
negative regulation of apoptosis
IDA
GO:0043154
negative regulation of caspase activity
IEA
GO:0043200
response to amino acid stimulus
IEA
GO:0043410
positive regulation of MAPKKK cascade
IDA
GO:0043526
neuroprotection
IEA
GO:0045079
negative regulation of chemokine biosynthetic process
IEA
GO:0045079
negative regulation of chemokine biosynthetic process
ISS
GO:0045188
regulation of circadian sleep/wake cycle, non-REM sleep
IEA
GO:0045429
positive regulation of nitric oxide biosynthetic process
IEA
GO:0045454
cell redox homeostasis
IEA
GO:0045599
negative regulation of fat cell differentiation
NAS
GO:0045630
positive regulation of T-helper 2 cell differentiation
IEA
GO:0045666
positive regulation of neuron differentiation
IEA
GO:0045669
positive regulation of osteoblast differentiation
TAS
GO:0045721
negative regulation of gluconeogenesis
IEA
GO:0045727
positive regulation of translation
IDA
GO:0045740
positive regulation of DNA replication
IEA
GO:0045765
regulation of angiogenesis
IC
GO:0045768
positive regulation of anti-apoptosis
IMP
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
IEA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0046427
positive regulation of JAK-STAT cascade
IDA
GO:0046427
positive regulation of JAK-STAT cascade
IEA
GO:0046677
response to antibiotic
IEA
GO:0046716
muscle cell homeostasis
IEA
GO:0046849
bone remodeling
IEA
GO:0046888
negative regulation of hormone secretion
IEA
GO:0048635
negative regulation of muscle organ development
IEA
GO:0048661
positive regulation of smooth muscle cell proliferation
IDA
GO:0050679
positive regulation of epithelial cell proliferation
IEA
GO:0050710
negative regulation of cytokine secretion
IEA
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
IDA
GO:0050829
defense response to Gram-negative bacterium
IEP
GO:0050830
defense response to Gram-positive bacterium
IEP
GO:0050871
positive regulation of B cell activation
IDA
GO:0051024
positive regulation of immunoglobulin secretion
IDA
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IDA
GO:0051092
positive regulation of NF-kappaB transcription factor activity
IDA
GO:0051384
response to glucocorticoid stimulus
IDA
GO:0051592
response to calcium ion
IEA
GO:0051602
response to electrical stimulus
IEA
GO:0051607
defense response to virus
IDA
GO:0051897
positive regulation of protein kinase B signaling cascade
IEA
GO:0051971
positive regulation of transmission of nerve impulse
IEA
GO:0060445
branching involved in salivary gland morphogenesis
IEA
GO:0060664
epithelial cell proliferation involved in salivary gland morphogenesis
IEA
GO:0070091
glucagon secretion
IEA
GO:0070091
glucagon secretion
ISS
GO:0070102
interleukin-6-mediated signaling pathway
IDA
GO:0070102
interleukin-6-mediated signaling pathway
IEA
GO:0070301
cellular response to hydrogen peroxide
IDA
GO:0070374
positive regulation of ERK1 and ERK2 cascade
IEA
GO:2000366
positive regulation of STAT protein import into nucleus
IC
cellular_component
GO:0005576
extracellular region
IEA
GO:0005576
extracellular region
TAS
GO:0005615
extracellular space
IDA
GO:0005615
extracellular space
IEA
GO:0005896
interleukin-6 receptor complex
IDA
GO:0009897
external side of plasma membrane
IEA
molecular_function
GO:0005125
cytokine activity
IDA
GO:0005125
cytokine activity
IEA
GO:0005125
cytokine activity
NAS
GO:0005138
interleukin-6 receptor binding
IEA
GO:0005138
interleukin-6 receptor binding
IPI
GO:0005138
interleukin-6 receptor binding
NAS
GO:0008083
growth factor activity
IDA
Protein-protein interaction details for IL6 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
IL6R
Reconstituted Complex
physical
14557255
IL6R
Reconstituted Complex
physical
12643274
SH3GL2
Two-hybrid
physical
16169070
IL6R
Affinity Capture-Western
physical
2788034