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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IL12B (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001916positive regulation of T cell mediated cytotoxicityISS
GO:0002230positive regulation of defense response to virus by hostIDA
GO:0002230positive regulation of defense response to virus by hostISS
GO:0002827positive regulation of T-helper 1 type immune responseIDA
GO:0002827positive regulation of T-helper 1 type immune responseISS
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDA
GO:0002862negative regulation of inflammatory response to antigenic stimulusIEA
GO:0007050cell cycle arrestIDA
GO:0007165signal transductionTAS
GO:0010224response to UV-BIDA
GO:0010535positive regulation of activation of JAK2 kinase activityIDA
GO:0016477cell migrationIDA
GO:0019953sexual reproductionTAS
GO:0030101natural killer cell activationIDA
GO:0032693negative regulation of interleukin-10 productionIMP
GO:0032700negative regulation of interleukin-17 productionIDA
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor productionIDA
GO:0032729positive regulation of interferon-gamma productionIDA
GO:0032733positive regulation of interleukin-10 productionIDA
GO:0032733positive regulation of interleukin-10 productionTAS
GO:0032735positive regulation of interleukin-12 productionIDA
GO:0032740positive regulation of interleukin-17 productionIDA
GO:0032760positive regulation of tumor necrosis factor productionIMP
GO:0032816positive regulation of natural killer cell activationIC
GO:0032816positive regulation of natural killer cell activationIDA
GO:0032819positive regulation of natural killer cell proliferationIDA
GO:0034105positive regulation of tissue remodelingIC
GO:0034393positive regulation of smooth muscle cell apoptosisIDA
GO:0042035regulation of cytokine biosynthetic processTAS
GO:0042088T-helper 1 type immune responseTAS
GO:0042093T-helper cell differentiationIDA
GO:0042095interferon-gamma biosynthetic processTAS
GO:0042102positive regulation of T cell proliferationIDA
GO:0042104positive regulation of activated T cell proliferationIDA
GO:0042346positive regulation of NF-kappaB import into nucleusTAS
GO:0042510regulation of tyrosine phosphorylation of Stat1 proteinIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042520positive regulation of tyrosine phosphorylation of Stat4 proteinIDA
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0042832defense response to protozoanIEA
GO:0043382positive regulation of memory T cell differentiationISS
GO:0044130negative regulation of growth of symbiont in hostIEA
GO:0045078positive regulation of interferon-gamma biosynthetic processTAS
GO:0045672positive regulation of osteoclast differentiationIDA
GO:0045785positive regulation of cell adhesionIDA
GO:0048662negative regulation of smooth muscle cell proliferationIDA
GO:0050671positive regulation of lymphocyte proliferationIDA
GO:0050729positive regulation of inflammatory responseIC
GO:0050829defense response to Gram-negative bacteriumIDA
GO:0051135positive regulation of NK T cell activationIC
GO:0051135positive regulation of NK T cell activationIDA
GO:0051142positive regulation of NK T cell proliferationIDA
GO:0051607defense response to virusIEA
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071346cellular response to interferon-gammaIEA
GO:2000318positive regulation of T-helper 17 type immune responseISS
GO:2000330positive regulation of T-helper 17 cell lineage commitmentISS
cellular_component
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceTAS
GO:0005737cytoplasmIEA
GO:0016020membraneIEA
GO:0043514interleukin-12 complexIDA
GO:0070743interleukin-23 complexIDA
molecular_function
GO:0004871signal transducer activityTAS
GO:0004896cytokine receptor activityIEA
GO:0005125cytokine activityIDA
GO:0005143interleukin-12 receptor bindingTAS
GO:0005515protein bindingIPI
GO:0008083growth factor activityIDA
GO:0042164interleukin-12 alpha subunit bindingIEA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIEA
GO:0045519interleukin-23 receptor bindingIDA
GO:0046982protein heterodimerization activityIPI

Protein-protein interaction details for IL12B (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
IL12ACo-crystal Structurephysical10899108
IL23AAffinity Capture-Westernphysical11114383
IL23AAffinity Capture-Westernphysical11114383