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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for INPP5D (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006796 phosphate-containing compound metabolic process TAS GO:0007165 signal transduction TAS GO:0007596 blood coagulation TAS GO:0008285 negative regulation of cell proliferation IEA GO:0008340 determination of adult lifespan IEA GO:0009968 negative regulation of signal transduction IEA GO:0016064 immunoglobulin mediated immune response IEA GO:0030889 negative regulation of B cell proliferation IEA GO:0035556 intracellular signal transduction IEA GO:0043065 positive regulation of apoptosis IEA GO:0045409 negative regulation of interleukin-6 biosynthetic process IEA GO:0045579 positive regulation of B cell differentiation IEA GO:0045648 positive regulation of erythrocyte differentiation IEA GO:0045656 negative regulation of monocyte differentiation IEA GO:0045659 negative regulation of neutrophil differentiation IEA GO:0045671 negative regulation of osteoclast differentiation IEA GO:0045779 negative regulation of bone resorption IEA GO:0050777 negative regulation of immune response IEA GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS cellular_component GO:0005625 soluble fraction IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005884 actin filament IEA GO:0005886 plasma membrane IEA GO:0030863 cortical cytoskeleton IEA molecular_function GO:0004437 inositol or phosphatidylinositol phosphatase activity IEA GO:0004445 inositol-polyphosphate 5-phosphatase activity IEA GO:0016787 hydrolase activity IEA GO:0017124 SH3 domain binding IEA GO:0030487 inositol-4,5-bisphosphate 5-phosphatase activity IEA GO:0034594 phosphatidylinositol trisphosphate phosphatase activity IEA GO:0051425 PTB domain binding IEA

Protein-protein interaction details for INPP5D (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DOK1 Affinity Capture-Western physical 10822173 DOK2 Affinity Capture-Western physical 10822173 SHC1 Affinity Capture-Western physical 10822173 DOK1 Affinity Capture-Western physical 10822173 DOK2 Affinity Capture-Western physical 10822173 SHC1 Affinity Capture-Western physical 10822173 LYN Affinity Capture-Western physical 12882960 LYN Reconstituted Complex physical 12882960 SHC1 Affinity Capture-Western physical 10194451 CD22 Affinity Capture-Western physical 10748054 CD22 Affinity Capture-Western physical 10748054 DOK1 Reconstituted Complex physical 11071635 KIT Reconstituted Complex physical 11071635 DAB2 Reconstituted Complex physical 11247302 SHC1 Affinity Capture-Western physical 12024011 PRKCD Affinity Capture-Western physical 12024011 IL4R Reconstituted Complex physical 11714803 PTPN11 Affinity Capture-Western physical 9110989 SLAMF1 Affinity Capture-Western physical 10229804 PIK3R1 Affinity Capture-Western physical 9918857 SHC1 Affinity Capture-Western physical 8643691 SHC1 Affinity Capture-Western physical 8643691 PECAM1 Reconstituted Complex physical 10350061 PECAM1 Far Western physical 10350061 SHC1 Affinity Capture-Western physical 10900203 GRB2 Protein-peptide physical 8723348 GRB2 Affinity Capture-Western physical 8723348 CRKL Reconstituted Complex physical 11443118 CRKL Affinity Capture-Western physical 11443118 TRIP10 Affinity Capture-MS physical 19041431 EPOR PCA physical 15644415 BCR Affinity Capture-Western physical 20304029 UBC Affinity Capture-Western physical 20304029 CLYBL Affinity Capture-Western physical 20304029 MME Affinity Capture-MS physical 17342744 UBC Affinity Capture-Western physical 19880507 ARAP1 Two-hybrid physical 21275903