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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for INSR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity IMP GO:0001933 negative regulation of protein phosphorylation IEA GO:0001934 positive regulation of protein phosphorylation IDA GO:0003007 heart morphogenesis IMP GO:0005975 carbohydrate metabolic process IEA GO:0006355 regulation of transcription, DNA-dependent IMP GO:0007186 G-protein coupled receptor protein signaling pathway IDA GO:0008284 positive regulation of cell proliferation IC GO:0008284 positive regulation of cell proliferation IDA GO:0008286 insulin receptor signaling pathway IDA GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0009725 response to hormone stimulus IEA GO:0009749 response to glucose stimulus IEA GO:0010042 response to manganese ion IEA GO:0010310 regulation of hydrogen peroxide metabolic process IEA GO:0010560 positive regulation of glycoprotein biosynthetic process IEA GO:0010629 negative regulation of gene expression IEA GO:0014823 response to activity IEA GO:0018108 peptidyl-tyrosine phosphorylation IDA GO:0019087 transformation of host cell by virus IMP GO:0030335 positive regulation of cell migration IMP GO:0031667 response to nutrient levels IEA GO:0032147 activation of protein kinase activity IMP GO:0032148 activation of protein kinase B activity IDA GO:0032355 response to estradiol stimulus IEA GO:0032410 negative regulation of transporter activity IEA GO:0032869 cellular response to insulin stimulus IDA GO:0033280 response to vitamin D IEA GO:0033574 response to testosterone stimulus IEA GO:0034612 response to tumor necrosis factor IEA GO:0042593 glucose homeostasis IMP GO:0043410 positive regulation of MAPKKK cascade IMP GO:0045429 positive regulation of nitric oxide biosynthetic process IMP GO:0045444 fat cell differentiation IEA GO:0045471 response to ethanol IEA GO:0045725 positive regulation of glycogen biosynthetic process IDA GO:0045740 positive regulation of DNA replication IMP GO:0045821 positive regulation of glycolysis IMP GO:0045840 positive regulation of mitosis IMP GO:0045995 regulation of embryonic development IMP GO:0046326 positive regulation of glucose import IDA GO:0046326 positive regulation of glucose import NAS GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation IMP GO:0048639 positive regulation of developmental growth IMP GO:0051290 protein heterotetramerization IDA GO:0051384 response to glucocorticoid stimulus IEA GO:0051897 positive regulation of protein kinase B signaling cascade IMP GO:0060267 positive regulation of respiratory burst IDA cellular_component GO:0005625 soluble fraction IEA GO:0005634 nucleus IEA GO:0005768 endosome IEA GO:0005792 microsome IDA GO:0005829 cytosol IEA GO:0005886 plasma membrane IC GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane IDA GO:0005899 insulin receptor complex IMP GO:0005901 caveola IDA GO:0010008 endosome membrane TAS GO:0016020 membrane IDA GO:0045202 synapse IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity IMP GO:0004716 receptor signaling protein tyrosine kinase activity IDA GO:0004872 receptor activity IEA GO:0005009 insulin-activated receptor activity IDA GO:0005159 insulin-like growth factor receptor binding IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0005525 GTP binding IDA GO:0019903 protein phosphatase binding IEA GO:0031405 lipoic acid binding IEA GO:0031994 insulin-like growth factor I binding IPI GO:0031995 insulin-like growth factor II binding IPI GO:0032403 protein complex binding IEA GO:0042169 SH2 domain binding IPI GO:0043423 3-phosphoinositide-dependent protein kinase binding IEA GO:0043548 phosphatidylinositol 3-kinase binding IPI GO:0043559 insulin binding IDA GO:0043559 insulin binding IPI GO:0043560 insulin receptor substrate binding IPI GO:0046872 metal ion binding IEA GO:0051425 PTB domain binding IPI

Protein-protein interaction details for INSR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CSK Two-hybrid physical 10026153 IRS1 Two-hybrid physical 11606564 FRS2 Biochemical Activity physical 10650943 SOCS3 Affinity Capture-Western physical 12560330 IRS2 Two-hybrid physical 8626379 IRS1 Two-hybrid physical 8626379 GRB10 Affinity Capture-Western physical 10871840 MAPK1 Affinity Capture-Western physical 11409918 MAPK3 Affinity Capture-Western physical 11409918 AHSG Reconstituted Complex physical 7906861 KHDRBS1 Affinity Capture-Western physical 11604231 PTPN11 Reconstituted Complex physical 8135823 GRB10 Two-hybrid physical 8621530 GRB10 Reconstituted Complex physical 8621530 GRB10 Affinity Capture-Western physical 8621530 PTPN6 Affinity Capture-Western physical 7512963 ENPP1 Affinity Capture-Western physical 10615944 ENPP1 Reconstituted Complex physical 10615944 HRAS Biochemical Activity physical 3109943 GRB10 Two-hybrid physical 7479769 GRB10 Affinity Capture-Western physical 7479769 GRB10 Reconstituted Complex physical 7479769 CAV1 Affinity Capture-Western physical 10598578 GRB2 Affinity Capture-Western physical 9083103 SMAD2 Two-hybrid physical 9092546 SMAD2 Affinity Capture-Western physical 9092546 SMAD2 Reconstituted Complex physical 9092546 PRKCD Affinity Capture-Western physical 11266508 VAV3 Affinity Capture-Western physical 11094073 INSRR Affinity Capture-Western physical 8916919 SH2B1 Affinity Capture-Western physical 9742218 SH2B1 Two-hybrid physical 9742218 GRB10 Two-hybrid physical 9506989 GRB10 Reconstituted Complex physical 9506989 PRKCD Affinity Capture-Western physical 12031982 INPPL1 Affinity Capture-Western physical 12504111 SNX6 Affinity Capture-Western physical 11279102 GRB10 Affinity Capture-Western physical 9006901 SNX1 Affinity Capture-Western physical 9819414 SNX2 Affinity Capture-Western physical 9819414 SNX4 Affinity Capture-Western physical 9819414 RASA1 Affinity Capture-Western physical 1331107 JAK2 Affinity Capture-Western physical 8912646 VAV1 Reconstituted Complex physical 7535775 PTPN11 Affinity Capture-Western physical 7493946 PTPN11 Reconstituted Complex physical 7493946 GRB7 Two-hybrid physical 10803466 SHC1 Two-hybrid physical 10803466 GRB7 Reconstituted Complex physical 10803466 SYNCRIP Biochemical Activity physical 11994298 GRB14 Affinity Capture-Western physical 11726652 PTPN1 Affinity Capture-Western physical 11726652 SORBS1 Affinity Capture-Western physical 11374898 SH2B1 Two-hybrid physical 10594240 SH2B1 Reconstituted Complex physical 10594240 UBC Affinity Capture-Western physical 16434550