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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IRAK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0001959 regulation of cytokine-mediated signaling pathway IMP GO:0002218 activation of innate immune response TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006468 protein phosphorylation TAS GO:0006916 anti-apoptosis TAS GO:0007165 signal transduction IEA GO:0007165 signal transduction NAS GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway NAS GO:0007250 activation of NF-kappaB-inducing kinase activity IDA GO:0007254 JNK cascade TAS GO:0008063 Toll signaling pathway TAS GO:0016567 protein ubiquitination TAS GO:0031663 lipopolysaccharide-mediated signaling pathway IMP GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP GO:0032494 response to peptidoglycan IEA GO:0032496 response to lipopolysaccharide IMP GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway IMP GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade TAS GO:0043507 positive regulation of JUN kinase activity IEA GO:0045087 innate immune response TAS GO:0045892 negative regulation of transcription, DNA-dependent IEA GO:0045893 positive regulation of transcription, DNA-dependent NAS GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation NAS GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0051259 protein oligomerization IMP GO:0051403 stress-activated MAPK cascade TAS GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070498 interleukin-1-mediated signaling pathway IMP GO:0070555 response to interleukin-1 IMP GO:0090370 negative regulation of cholesterol efflux IEA cellular_component GO:0005624 membrane fraction IEA GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0010008 endosome membrane TAS GO:0045323 interleukin-1 receptor complex NAS molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IDA GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity EXP GO:0004674 protein serine/threonine kinase activity IEA GO:0004674 protein serine/threonine kinase activity NAS GO:0004704 NF-kappaB-inducing kinase activity TAS GO:0004842 ubiquitin-protein ligase activity TAS GO:0004872 receptor activity IEA GO:0005149 interleukin-1 receptor binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity IDA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0042803 protein homodimerization activity IPI GO:0042803 protein homodimerization activity NAS GO:0046982 protein heterodimerization activity IPI

Protein-protein interaction details for IRAK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SIGIRR Affinity Capture-Western physical 12925853 AKT1 Affinity Capture-Western physical 11976320 MYD88 Affinity Capture-Western physical 11976320 IL1RAP Affinity Capture-Western physical 9371760 PRKCZ Affinity Capture-Western physical 11937546 SQSTM1 Affinity Capture-Western physical 10747026 MYD88 Affinity Capture-Western physical 10383454 TRAF6 Affinity Capture-Western physical 10383454 TRAF6 Affinity Capture-Western physical 11518704 TOLLIP Affinity Capture-Western physical 10854325 IRAK1BP1 Two-hybrid physical 11096118 IRAK1BP1 Affinity Capture-Western physical 11096118 IKBKB Affinity Capture-Western physical 11096118 CHUK Affinity Capture-Western physical 11096118 TRAF6 Affinity Capture-Western physical 8837778 TLR2 Affinity Capture-Western physical 10395652 TIFA Affinity Capture-Western physical 12566447 TRAF6 Affinity Capture-Western physical 12566447 MYD88 Affinity Capture-Western physical 11960013 TRAF6 Affinity Capture-Western physical 11960013 IRAK4 Affinity Capture-Western physical 11960013 IRAK4 Biochemical Activity physical 11960013 TRAF6 Affinity Capture-Western physical 10920205 TRAF6 Affinity Capture-Western physical 10920205 ITGAM Affinity Capture-Western physical 11701612 TRAF6 Two-hybrid physical 11259596 IRAK1 Two-hybrid physical 11259596 MYD88 Phenotypic Suppression genetic 11544529 MYD88 Affinity Capture-Western physical 11544529 TRAF6 Affinity Capture-Western physical 9374458 UBC Affinity Capture-Western physical 18724939 UBC Affinity Capture-Western physical 18347055 IKBKG Reconstituted Complex physical 18347055 IKBKG Affinity Capture-Western physical 18347055 UBC Affinity Capture-Western physical 18326498 PELI3 Affinity Capture-Western physical 18326498 TRAF6 Affinity Capture-Western physical 18234474 IKBKG Reconstituted Complex physical 18180283 IKBKG Affinity Capture-Western physical 18180283 CHUK Affinity Capture-Western physical 18180283 IKBKB Affinity Capture-Western physical 18180283 UBC Affinity Capture-Western physical 18180283 TAB2 Affinity Capture-Western physical 18180283 PELI3 Affinity Capture-Western physical 17675297 PELI1 Affinity Capture-Western physical 17675297 PELI2 Affinity Capture-Western physical 17675297 TOLLIP Affinity Capture-Western physical 17113392 BCL10 Reconstituted Complex physical 16831874 CAMKK2 Affinity Capture-MS physical 20562859 CLN3 Affinity Capture-MS physical 20562859 IRAK4 PCA physical 18221795 TRAF6 Affinity Capture-Western physical 11287640 TRAF6 Affinity Capture-Western physical 11287640 PELI1 Biochemical Activity physical 17997719 IKBKG Affinity Capture-Western physical 17997719 PELI1 Reconstituted Complex physical 19081057 PPP2CA Affinity Capture-Western physical 21708940 PPP2CA Affinity Capture-Western physical 21708940 MYC Affinity Capture-MS physical 17314511 TLR4 Affinity Capture-Western physical 21911421 TLR9 Affinity Capture-Western physical 21911421 UBC Affinity Capture-Western physical 21220427 TRAF6 Affinity Capture-Western physical 21220427 IKBKG Affinity Capture-Western physical 21220427 TRAF6 Affinity Capture-Western physical 21220427 TNFAIP3 Affinity Capture-Western physical 21220427 PELI1 Biochemical Activity physical 19264966 TRAF6 Affinity Capture-Western physical 20043910 UBC Affinity Capture-Western physical 20043910 TAB2 Affinity Capture-Western physical 19675569 UBC Reconstituted Complex physical 19675569 TRAF6 Affinity Capture-Western physical 22033459 MAP3K7 Affinity Capture-Western physical 19026643 TRIM32 Affinity Capture-MS physical 21903422 BAG3 Affinity Capture-MS physical 21903422 CABC1 Affinity Capture-MS physical 21903422 CCDC47 Affinity Capture-MS physical 21903422 IQSEC1 Affinity Capture-MS physical 21903422 IRAK2 Affinity Capture-MS physical 21903422 MAGED1 Affinity Capture-MS physical 21903422 PJA1 Affinity Capture-MS physical 21903422 PPP3CB Affinity Capture-MS physical 21903422 RHOT1 Affinity Capture-MS physical 21903422 SNRNP200 Affinity Capture-MS physical 21903422 TARDBP Affinity Capture-MS physical 21903422 TOMM70A Affinity Capture-MS physical 21903422 YTHDC2 Affinity Capture-MS physical 21903422 IRAK2 Affinity Capture-MS physical 21903422 IRAK3 Affinity Capture-MS physical 21903422 IRAK4 Affinity Capture-MS physical 21903422 IRF4 Affinity Capture-MS physical 21903422 IRF7 Affinity Capture-MS physical 21903422 TIRAP Affinity Capture-MS physical 21903422 MYD88 Affinity Capture-MS physical 21903422 SARM1 Affinity Capture-MS physical 21903422 TMEM173 Affinity Capture-MS physical 21903422 TOLLIP Affinity Capture-MS physical 21903422 UNC93B1 Affinity Capture-MS physical 21903422 CCDC47 Reconstituted Complex physical 21903422 PPP3CB Reconstituted Complex physical 21903422 TRIM32 Reconstituted Complex physical 21903422 YTHDC2 Reconstituted Complex physical 21903422 IRF4 Reconstituted Complex physical 21903422 IRF7 Reconstituted Complex physical 21903422 TIRAP Reconstituted Complex physical 21903422 TMEM173 Reconstituted Complex physical 21903422 UNC93B1 Reconstituted Complex physical 21903422 UBC Affinity Capture-Western physical 21435586 UBC Affinity Capture-MS physical 21987572