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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IRS1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002053 positive regulation of mesenchymal cell proliferation IEA GO:0007165 signal transduction TAS GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS GO:0008284 positive regulation of cell proliferation NAS GO:0008286 insulin receptor signaling pathway IDA GO:0008286 insulin receptor signaling pathway IMP GO:0008286 insulin receptor signaling pathway IPI GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0010468 regulation of gene expression IEA GO:0010907 positive regulation of glucose metabolic process IMP GO:0014065 phosphatidylinositol 3-kinase cascade IDA GO:0016042 lipid catabolic process IEA GO:0030335 positive regulation of cell migration IEA GO:0030879 mammary gland development IEA GO:0032000 positive regulation of fatty acid beta-oxidation IMP GO:0032868 response to insulin stimulus IDA GO:0032869 cellular response to insulin stimulus IMP GO:0034504 protein localization to nucleus IEA GO:0042327 positive regulation of phosphorylation IEA GO:0042593 glucose homeostasis TAS GO:0043434 response to peptide hormone stimulus ISS GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS GO:0045725 positive regulation of glycogen biosynthetic process IMP GO:0045725 positive regulation of glycogen biosynthetic process NAS GO:0046326 positive regulation of glucose import IMP GO:0046627 negative regulation of insulin receptor signaling pathway ISS GO:0046628 positive regulation of insulin receptor signaling pathway ISS GO:0046676 negative regulation of insulin secretion IDA GO:0048009 insulin-like growth factor receptor signaling pathway IPI GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0051291 protein heterooligomerization IEA GO:0070094 positive regulation of glucagon secretion IEA GO:0090275 negative regulation of somatostatin secretion IEA cellular_component GO:0005634 nucleus ISS GO:0005737 cytoplasm ISS GO:0005792 microsome ISS GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0005899 insulin receptor complex ISS GO:0005901 caveola IDA molecular_function GO:0004871 signal transducer activity IEA GO:0005010 insulin-like growth factor-activated receptor activity IEA GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity ISS GO:0005080 protein kinase C binding ISS GO:0005158 insulin receptor binding IPI GO:0005159 insulin-like growth factor receptor binding IPI GO:0005515 protein binding IPI GO:0042169 SH2 domain binding ISS GO:0043548 phosphatidylinositol 3-kinase binding IPI GO:0043548 phosphatidylinositol 3-kinase binding ISS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS

Protein-protein interaction details for IRS1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IGF1R Two-hybrid physical 7559507 PTK2 Two-hybrid physical 9822703 MAPK8 Two-hybrid physical 11606564 INSR Two-hybrid physical 11606564 SFN Affinity Capture-MS physical 15778465 SOCS1 Affinity Capture-Western physical 12228220 PIK3R3 Affinity Capture-Western physical 10417350 INSR Two-hybrid physical 8626379 PIK3R1 Affinity Capture-Western physical 1381348 GRB2 Affinity Capture-Western physical 8491186 GRB2 Affinity Capture-Western physical 8491186 GRB2 Reconstituted Complex physical 8491186 JAK1 Biochemical Activity physical 9492017 JAK2 Biochemical Activity physical 9492017 KHDRBS1 Affinity Capture-Western physical 11604231 PTPN1 Reconstituted Complex physical 10660596 PIK3R3 Affinity Capture-Western physical 9415396 GRB10 Reconstituted Complex physical 8621530 PIK3R1 Affinity Capture-Western physical 12173038 GRB2 Affinity Capture-Western physical 12173038 CHUK Affinity Capture-Western physical 12351658 IKBKB Affinity Capture-Western physical 12351658 IGF1R Two-hybrid physical 8776723 IGF1R Two-hybrid physical 8776723 YWHAE Reconstituted Complex physical 9111084 YWHAE Two-hybrid physical 9111084 PTPN11 Reconstituted Complex physical 8505282 BCL2 Affinity Capture-Western physical 10679027 BCL2 Affinity Capture-Western physical 10679027 BCL2L1 Affinity Capture-Western physical 10679027 MTOR Affinity Capture-Western physical 11287630 PIK3CA Affinity Capture-Western physical 16354680 PIK3R1 Affinity Capture-Western physical 12730242 JAK3 Affinity Capture-Western physical 7499365 JAK1 Affinity Capture-Western physical 7499365 AP3S1 Reconstituted Complex physical 9792713 PTPN11 Affinity Capture-Western physical 9756938 IGF1R Affinity Capture-Western physical 10082579 MAPK8 Affinity Capture-Western physical 10722755 MAPK8 Reconstituted Complex physical 10722755 PTPN1 Affinity Capture-Western physical 11579209 SHC1 Reconstituted Complex physical 7499194 YWHAH Affinity Capture-Western physical 11969417 JAK2 Affinity Capture-Western physical 11208867 PRKCD Affinity Capture-Western physical 12031982 NISCH Affinity Capture-Western physical 11912194 YWHAB Reconstituted Complex physical 9422753 PIK3R1 Far Western physical 12107746 GRB2 Reconstituted Complex physical 8536716 NCK2 Reconstituted Complex physical 9843575 AKT1 Affinity Capture-Western physical 10497255 IRS2 Co-fractionation physical 12554758 UBTF Affinity Capture-Western physical 12554758 PTK2 Affinity Capture-Western physical 9822703 ALK Affinity Capture-Western physical 14968112 CBLB Affinity Capture-Western physical 16734387 HDAC2 Two-hybrid physical 15522123 HDAC2 Reconstituted Complex physical 15522123 HDAC2 Affinity Capture-Western physical 15522123 UBC Affinity Capture-Western physical 15516986 PRKCD Biochemical Activity physical 15516986 UBC Affinity Capture-Western physical 12821935 ESR1 Affinity Capture-Western physical 12821935 ESR1 Affinity Capture-Western physical 12821935 UBTF Affinity Capture-Western physical 17332342 UBC Affinity Capture-Western physical 20663861