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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for JAK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000186 activation of MAPKK activity IEA GO:0006468 protein phosphorylation NAS GO:0006915 apoptosis ISS GO:0006928 cellular component movement TAS GO:0007165 signal transduction ISS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007186 G-protein coupled receptor protein signaling pathway IEA GO:0007204 elevation of cytosolic calcium ion concentration IEA GO:0007243 intracellular protein kinase cascade ISS GO:0007259 JAK-STAT cascade IEA GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein ISS GO:0007262 STAT protein import into nucleus ISS GO:0007498 mesoderm development TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation ISS GO:0008631 induction of apoptosis by oxidative stress IEA GO:0008636 activation of caspase activity by protein phosphorylation ISS GO:0009755 hormone-mediated signaling pathway IEA GO:0010811 positive regulation of cell-substrate adhesion IDA GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade ISS GO:0016568 chromatin modification IEA GO:0018108 peptidyl-tyrosine phosphorylation ISS GO:0019221 cytokine-mediated signaling pathway IDA GO:0019221 cytokine-mediated signaling pathway ISS GO:0019221 cytokine-mediated signaling pathway TAS GO:0022408 negative regulation of cell-cell adhesion IEA GO:0030041 actin filament polymerization NAS GO:0030154 cell differentiation ISS GO:0030218 erythrocyte differentiation ISS GO:0030335 positive regulation of cell migration IEA GO:0031103 axon regeneration IEA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032496 response to lipopolysaccharide ISS GO:0032516 positive regulation of phosphoprotein phosphatase activity IEA GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033194 response to hydroperoxide IEA GO:0033209 tumor necrosis factor-mediated signaling pathway IDA GO:0034612 response to tumor necrosis factor IDA GO:0035409 histone H3-Y41 phosphorylation IDA GO:0035556 intracellular signal transduction TAS GO:0035722 interleukin-12-mediated signaling pathway IDA GO:0042503 tyrosine phosphorylation of Stat3 protein IEA GO:0042508 tyrosine phosphorylation of Stat1 protein IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity ISS GO:0043065 positive regulation of apoptosis IEA GO:0043065 positive regulation of apoptosis ISS GO:0043388 positive regulation of DNA binding IEA GO:0043392 negative regulation of DNA binding ISS GO:0043526 neuroprotection IEA GO:0045087 innate immune response IEA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045597 positive regulation of cell differentiation IEA GO:0045822 negative regulation of heart contraction IEA GO:0046677 response to antibiotic IDA GO:0046777 protein autophosphorylation IEA GO:0046777 protein autophosphorylation ISS GO:0048008 platelet-derived growth factor receptor signaling pathway IEA GO:0050727 regulation of inflammatory response IDA GO:0050729 positive regulation of inflammatory response IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0050867 positive regulation of cell activation IEA GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060333 interferon-gamma-mediated signaling pathway IEA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060396 growth hormone receptor signaling pathway IDA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS GO:0060399 positive regulation of growth hormone receptor signaling pathway ISS GO:0061180 mammary gland epithelium development ISS GO:0070671 response to interleukin-12 IDA cellular_component GO:0005624 membrane fraction IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005901 caveola ISS GO:0012505 endomembrane system IEA GO:0016020 membrane IEA GO:0016363 nuclear matrix IEA GO:0045121 membrane raft ISS molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity NAS GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0005102 receptor binding IPI GO:0005131 growth hormone receptor binding IEA GO:0005131 growth hormone receptor binding ISS GO:0005143 interleukin-12 receptor binding ISS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0019901 protein kinase binding IDA GO:0020037 heme binding IDA GO:0033130 acetylcholine receptor binding IEA GO:0035401 histone kinase activity (H3-Y41 specific) IDA GO:0042169 SH2 domain binding IPI GO:0042393 histone binding IDA GO:0042393 histone binding IEA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043560 insulin receptor substrate binding IEA GO:0051428 peptide hormone receptor binding IEA

Protein-protein interaction details for JAK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PRMT5 Two-hybrid physical 10531356 SOCS1 Two-hybrid physical 10064597 PPIA Affinity Capture-Western physical 12668872 PRMT5 Reconstituted Complex physical 10531356 IL12RB2 Reconstituted Complex physical 10198225 IL12RB2 Affinity Capture-Western physical 10198225 EPOR Affinity Capture-Western physical 11779507 EPOR Reconstituted Complex physical 11779507 FYN Affinity Capture-Western physical 10551884 FYN Reconstituted Complex physical 10551884 SOCS1 Affinity Capture-Western physical 11713228 STAT5A Affinity Capture-Western physical 9575217 STAT5B Affinity Capture-Western physical 9575217 SH2B2 Biochemical Activity physical 10374881 CXCR4 Affinity Capture-Western physical 10506573 DNAJA3 Affinity Capture-Western physical 11679576 DNAJA3 Affinity Capture-Western physical 11679576 HSPA8 Affinity Capture-Western physical 11679576 TEC Affinity Capture-Western physical 9178903 PTPN12 Affinity Capture-Western physical 11731619 PTK2 Affinity Capture-Western physical 9553131 CSF2RB Reconstituted Complex physical 7775438 CSF2RB Affinity Capture-Western physical 7775438 GHR Affinity Capture-Western physical 7540178 VAV1 Affinity Capture-Western physical 9162069 VAV1 Biochemical Activity physical 9162069 SIRPA Affinity Capture-Western physical 10842184 IRS1 Biochemical Activity physical 9492017 BRCA1 Affinity Capture-Western physical 11163768 GRB2 Affinity Capture-Western physical 7500025 GRB2 Affinity Capture-Western physical 7500025 EGFR Affinity Capture-Western physical 10358079 EGFR Affinity Capture-Western physical 10358079 PTK2B Affinity Capture-Western physical 11818507 PTPN11 Reconstituted Complex physical 8995399 PTPN11 Biochemical Activity physical 8995399 PPP2R4 Affinity Capture-Western physical 8702385 PPP2R4 Affinity Capture-Western physical 8702385 YES1 Affinity Capture-Western physical 8702385 YES1 Affinity Capture-Western physical 8702385 PIK3R1 Affinity Capture-Western physical 8702385 PIK3R1 Affinity Capture-Western physical 8702385 TNFRSF1A Reconstituted Complex physical 9510175 TNFRSF1A Affinity Capture-Western physical 9510175 STAT5A Two-hybrid physical 9047382 STAT5B Two-hybrid physical 9047382 STAT5A Reconstituted Complex physical 9047382 SOCS3 Affinity Capture-Western physical 10882725 SOCS3 Affinity Capture-Western physical 10882725 PTPN6 Affinity Capture-Western physical 8943354 LYN Reconstituted Complex physical 9573010 SOCS3 Two-hybrid physical 10421843 SOCS3 Affinity Capture-Western physical 10421843 SOCS3 Reconstituted Complex physical 10421843 HTR2A Affinity Capture-Western physical 9169451 ERBB2 Affinity Capture-Western physical 11940572 SOCS1 Two-hybrid physical 9202126 SOCS1 Reconstituted Complex physical 9202126 SOCS1 Affinity Capture-Western physical 9202126 ELP2 Affinity Capture-Western physical 10954736 VAV1 Affinity Capture-Western physical 7530656 CSF2RB Affinity Capture-Western physical 7527392 KIT Affinity Capture-Western physical 7527392 RAF1 Reconstituted Complex physical 8876196 SH2B1 Two-hybrid physical 9343427 SH2B1 Reconstituted Complex physical 9343427 SH2B1 Affinity Capture-Western physical 9343427 IL5RA Affinity Capture-Western physical 9516124 IL5RA Reconstituted Complex physical 9516124 PPP2R1B Affinity Capture-Western physical 11440634 IFNGR1 Affinity Capture-Western physical 7673114 IFNGR2 Reconstituted Complex physical 7673114 SOCS1 Reconstituted Complex physical 10064597 SOCS1 Affinity Capture-Western physical 10064597 PTPN11 Biochemical Activity physical 8639815 IRS1 Affinity Capture-Western physical 11208867 CCR5 Affinity Capture-Western physical 11278738 PTK2 Affinity Capture-Western physical 10925297 SOCS1 Affinity Capture-Western physical 10455112 PRLR Affinity Capture-Western physical 9202403 IL6ST Affinity Capture-Western physical 9388212 SHC1 Reconstituted Complex physical 7535773 GRB10 Affinity Capture-Western physical 9632636 TUB Biochemical Activity physical 10455176 GRB2 Reconstituted Complex physical 8536716 TSHR Affinity Capture-Western physical 10809230 EPOR Reconstituted Complex physical 8343951 PTPN6 Affinity Capture-Western physical 10772872 GHR Affinity Capture-Western physical 8063815 STAT3 Affinity Capture-Western physical 9211920 TEC Biochemical Activity physical 9473212 SOCS1 Affinity Capture-Western physical 11971965 SOCS3 Two-hybrid physical 9344848 SOCS3 Reconstituted Complex physical 9344848 SOCS1 Reconstituted Complex physical 9344848 SH2B1 Affinity Capture-Western physical 12370803 INSR Affinity Capture-Western physical 8912646 PTPN11 Affinity Capture-Western physical 8912646 STAM Biochemical Activity physical 9133424 STAM Affinity Capture-Western physical 9133424 SHC1 Reconstituted Complex physical 9126968 PTPN1 Affinity Capture-Western physical 11694501 STAM2 Affinity Capture-Western physical 10899310 GHR Affinity Capture-Western physical 10502458 IL2RB Affinity Capture-Western physical 9553136 CTLA4 Affinity Capture-Western physical 10842319 ALK Affinity Capture-MS physical 14968112 IKBKG Reconstituted Complex physical 20098747 FGFR1 Affinity Capture-Western physical 20388777 UBC Affinity Capture-Western physical 11278610 STAT1 Affinity Capture-Western physical 20353823 STAT1 Affinity Capture-Western physical 20353823 HSP90AA1 Affinity Capture-Western physical 20353823 HSP90AB1 Affinity Capture-Western physical 20353823 PRMT5 Affinity Capture-Western physical 21316606 PRMT5 Affinity Capture-Western physical 21316606 PRMT5 Biochemical Activity physical 21316606 CSF2RB Affinity Capture-Western physical 21965659 PRLR Affinity Capture-Western physical 20962278 UBC Affinity Capture-Western physical 21119685 ASB2 Affinity Capture-Western physical 21119685 SKP2 Affinity Capture-Western physical 21119685 ASB2 Affinity Capture-Western physical 21119685 SKP2 Affinity Capture-Western physical 21119685 GTF2I Biochemical Activity physical 11313464