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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for RHOA (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000902 cell morphogenesis IEA GO:0006184 GTP catabolic process TAS GO:0006357 regulation of transcription from RNA polymerase II promoter IEA GO:0007155 cell adhesion IEA GO:0007160 cell-matrix adhesion IEA GO:0007264 small GTPase mediated signal transduction IEA GO:0007264 small GTPase mediated signal transduction TAS GO:0007266 Rho protein signal transduction TAS GO:0007411 axon guidance TAS GO:0007519 skeletal muscle tissue development IEA GO:0007596 blood coagulation TAS GO:0030036 actin cytoskeleton organization IEA GO:0030036 actin cytoskeleton organization TAS GO:0030154 cell differentiation IEA GO:0030168 platelet activation TAS GO:0030334 regulation of cell migration IMP GO:0030521 androgen receptor signaling pathway IEA GO:0033144 negative regulation of steroid hormone receptor signaling pathway IEA GO:0042346 positive regulation of NF-kappaB import into nucleus NAS GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0043149 stress fiber assembly IEA GO:0043524 negative regulation of neuron apoptosis IEA GO:0044419 interspecies interaction between organisms IEA GO:0045666 positive regulation of neuron differentiation IMP GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050770 regulation of axonogenesis TAS GO:0050771 negative regulation of axonogenesis TAS GO:0050772 positive regulation of axonogenesis TAS GO:0051056 regulation of small GTPase mediated signal transduction TAS GO:0051496 positive regulation of stress fiber assembly IDA GO:0071777 positive regulation of cell cycle cytokinesis IMP GO:0090307 spindle assembly involved in mitosis IMP cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0005938 cell cortex IDA GO:0016020 membrane IEA GO:0032154 cleavage furrow IDA molecular_function GO:0000166 nucleotide binding IEA GO:0003924 GTPase activity IEA GO:0003924 GTPase activity TAS GO:0005515 protein binding IPI GO:0005525 GTP binding IEA GO:0017022 myosin binding IPI

Protein-protein interaction details for RHOA (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PDE6D Two-hybrid physical 11786539 RAP1GDS1 Two-hybrid physical 11948427 ARHGAP1 Two-hybrid physical 16189514 ARHGDIA Affinity Capture-MS physical 17353931 BID Co-purification physical 15659383 TNFRSF10B Co-purification physical 15659383 EZR Co-purification physical 15659383 FADD Co-purification physical 15659383 FASLG Co-purification physical 15659383 MAPK8 Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 FAS Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 TNFRSF1A Co-purification physical 15659383 GEFT Biochemical Activity physical 15069594 GEFT Reconstituted Complex physical 15069594 DEF6 Reconstituted Complex physical 15023524 ARHGAP32 Biochemical Activity physical 12857875 ARHGAP5 Affinity Capture-Western physical 12842009 ARHGAP5 Reconstituted Complex physical 12842009 ROCK1 Reconstituted Complex physical 12773565 PKN1 Reconstituted Complex physical 12773565 DIAPH1 Reconstituted Complex physical 12773565 CIT Reconstituted Complex physical 12773565 CIT Two-hybrid physical 12773565 ROCK1 Two-hybrid physical 12773565 PKN1 Two-hybrid physical 12773565 RHPN2 Two-hybrid physical 12773565 DIAPH1 Two-hybrid physical 12773565 KTN1 Two-hybrid physical 12773565 ROCK1 Affinity Capture-Western physical 12773565 ITPR1 Affinity Capture-Western physical 12766172 TRPC1 Affinity Capture-Western physical 12766172 ITPR1 Reconstituted Complex physical 12766172 TRPC1 Reconstituted Complex physical 12766172 ARHGEF1 Biochemical Activity physical 12748184 PLD1 Biochemical Activity physical 12593858 PLD1 Reconstituted Complex physical 12593858 RTKN Reconstituted Complex physical 12593858 NET1 Two-hybrid physical 9535835 PKN1 Reconstituted Complex physical 9535835 CRMP1 Phenotypic Suppression genetic 12482610 DPYSL2 Phenotypic Suppression genetic 12482610 CIT Two-hybrid physical 8543060 CIT Far Western physical 8543060 ARHGEF12 Reconstituted Complex physical 11373293 HSPA1A Affinity Capture-Western physical 12490434 KTN1 Two-hybrid physical 11162552 PLCG1 Affinity Capture-Western physical 12071848 PLCG1 Reconstituted Complex physical 12071848 ARHGEF3 Biochemical Activity physical 12221096 ARHGEF3 Reconstituted Complex physical 12221096 AKAP13 Affinity Capture-Western physical 11696353 PKN2 Reconstituted Complex physical 8910519 ICMT Biochemical Activity physical 9614111 VAV3 Reconstituted Complex physical 10523675 ARHGDIA Affinity Capture-Western physical 11149925 ARHGEF18 Reconstituted Complex physical 11085924 PLD1 Affinity Capture-Western physical 11311142 PLD1 Reconstituted Complex physical 11311142 ARHGAP26 Biochemical Activity physical 11432776 ARHGAP10 Biochemical Activity physical 11432776 KCNA2 Affinity Capture-Western physical 9635436 KCNA2 Reconstituted Complex physical 9635436 KCNA2 Two-hybrid physical 9635436 ARHGAP32 Biochemical Activity physical 12446789 KTN1 Two-hybrid physical 8769096 ARHGEF4 Reconstituted Complex physical 10947987 KTN1 Two-hybrid physical 11689693 ARHGEF2 Biochemical Activity physical 9857026 ARHGAP1 Biochemical Activity physical 9548756 ARHGAP1 Reconstituted Complex physical 9548756 GRLF1 Reconstituted Complex physical 9548756 ARHGEF11 Biochemical Activity physical 10526156 ARHGEF11 Reconstituted Complex physical 10526156 RAP1GDS1 Reconstituted Complex physical 11948427 ARHGAP32 Biochemical Activity physical 12454018 RIPK4 Two-hybrid physical 9199174 MPRIP Two-hybrid physical 9199174 MPRIP Reconstituted Complex physical 9199174 OPHN1 Biochemical Activity physical 9582072 ROCK1 Reconstituted Complex physical 8816443 ARHGAP1 Reconstituted Complex physical 9407060 DGKQ Affinity Capture-Western physical 10066731 DGKQ Reconstituted Complex physical 10066731 PKN1 Two-hybrid physical 9446575 PKN1 Far Western physical 9446575 PKN2 Far Western physical 9446575 PKN1 Reconstituted Complex physical 9446575 ROCK2 Affinity Capture-Western physical 11350930 ROCK1 Far Western physical 8798490 ROCK1 Two-hybrid physical 8798490 TRIO Affinity Capture-Western physical 10948190 TRIO Reconstituted Complex physical 10948190 TRIO Co-localization physical 10948190 MCF2 Reconstituted Complex physical 10854437 GNA12 Reconstituted Complex physical 12515866 ARHGEF12 Reconstituted Complex physical 12515866 TEC Reconstituted Complex physical 12515866 ARHGDIA Co-purification physical 9490022 PLEKHG2 Reconstituted Complex physical 11839748 ARHGDIG Reconstituted Complex physical 9113980 MCF2L Co-crystal Structure physical 12006984 ARHGAP1 Reconstituted Complex physical 9535855 CNTNAP1 Reconstituted Complex physical 9535855 BCR Reconstituted Complex physical 9535855 ARHGDIA Two-hybrid physical 11368848 UBC Affinity Capture-Western physical 17719543 PLXNB1 Affinity Capture-Western physical 19805522 RTKN Affinity Capture-Western physical 19805522 SMURF1 Reconstituted Complex physical 16622418 UBC Affinity Capture-Western physical 16622418 ARHGAP1 Affinity Capture-Western physical 20660160 GRLF1 Affinity Capture-Western physical 15102857 SMURF1 Biochemical Activity physical 21708152 SMURF1 Affinity Capture-Western physical 21708152 SMURF1 Reconstituted Complex physical 21708152 SMURF2 Reconstituted Complex physical 20026602 OTUB1 Affinity Capture-Western physical 20553488 UBC Reconstituted Complex physical 20553488 UBC Affinity Capture-MS physical 16196087 OTUB1 Biochemical Activity physical 20553488 UBC Affinity Capture-Western physical 19782033 CUL3 Affinity Capture-Western physical 19782033 CUL3 Biochemical Activity physical 19782033 UBC Reconstituted Complex physical 19782033 SRGAP1 Affinity Capture-Western physical 20856855 SRGAP1 Affinity Capture-Western physical 20856855 CAV1 Reconstituted Complex physical 20460433 UBC Affinity Capture-MS physical 21987572