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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SETD8 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0007049 cell cycle IEA GO:0007067 mitosis IEA GO:0016568 chromatin modification IEA GO:0018026 peptidyl-lysine monomethylation IDA GO:0034968 histone lysine methylation IDA GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IMP GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0051301 cell division IEA cellular_component GO:0005634 nucleus IEA GO:0005694 chromosome IEA molecular_function GO:0002039 p53 binding IPI GO:0003714 transcription corepressor activity IDA GO:0005515 protein binding IPI GO:0008168 methyltransferase activity IEA GO:0016279 protein-lysine N-methyltransferase activity IDA GO:0016740 transferase activity IEA GO:0018024 histone-lysine N-methyltransferase activity IDA GO:0018024 histone-lysine N-methyltransferase activity IEA

Protein-protein interaction details for SETD8 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID E2F2 Two-hybrid physical 12411495 RBBP4 Co-purification physical 12351676 EZH2 Co-purification physical 12351676 SUZ12 Co-purification physical 12351676 EED Co-purification physical 12351676 AEBP2 Co-purification physical 12351676 HIST1H4A Biochemical Activity physical 12121615 HIST1H4A Biochemical Activity physical 15964846 HIST1H4A Co-crystal Structure physical 15933070 HIST1H4A Co-crystal Structure physical 15933069 HIST1H4A Protein-peptide physical 15933069 PCNA Affinity Capture-Western physical 18319261 PCNA Reconstituted Complex physical 18319261 PCNA Affinity Capture-Western physical 18166648 DTL Affinity Capture-Western physical 20932472 DTL Reconstituted Complex physical 20932472 DDB1 Affinity Capture-Western physical 20932471 DTL Affinity Capture-Western physical 20932471 L3MBTL Affinity Capture-Western physical 20870725 HIST1H4A Co-crystal Structure physical 18512960 TP53 Biochemical Activity physical 17707234 PCNA Reconstituted Complex physical 21035370 PCNA Co-localization physical 21035370 TP53BP1 Co-localization physical 21035370 IL17RB Biochemical Activity physical 21035370 DTL Biochemical Activity physical 21035370 UBC Affinity Capture-Western physical 20966048 FZR1 Affinity Capture-Western physical 20966048 FZR1 Affinity Capture-Western physical 20966048 UBE2I Two-hybrid physical 21829513 UBE2I Affinity Capture-Western physical 21829513 UBE2I Reconstituted Complex physical 21829513 UBE2I Affinity Capture-Western physical 21829513 UBE2I Reconstituted Complex physical 21829513 SUMO1 Affinity Capture-Western physical 21829513 UBE2I Biochemical Activity physical 21829513