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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LIG4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000012 single strand break repair IDA GO:0001701 in utero embryonic development ISS GO:0002328 pro-B cell differentiation ISS GO:0006260 DNA replication IEA GO:0006266 DNA ligation IDA GO:0006281 DNA repair TAS GO:0006297 nucleotide-excision repair, DNA gap filling IDA GO:0006302 double-strand break repair IDA GO:0006302 double-strand break repair ISS GO:0006302 double-strand break repair TAS GO:0006303 double-strand break repair via nonhomologous end joining IDA GO:0006303 double-strand break repair via nonhomologous end joining IMP GO:0006303 double-strand break repair via nonhomologous end joining TAS GO:0007049 cell cycle IEA GO:0007417 central nervous system development ISS GO:0008283 cell proliferation ISS GO:0010165 response to X-ray IMP GO:0010332 response to gamma radiation ISS GO:0016032 viral reproduction TAS GO:0019047 provirus integration TAS GO:0019059 initiation of viral infection TAS GO:0033077 T cell differentiation in thymus ISS GO:0033151 V(D)J recombination IDA GO:0033153 T cell receptor V(D)J recombination ISS GO:0035019 somatic stem cell maintenance ISS GO:0043524 negative regulation of neuron apoptosis ISS GO:0045190 isotype switching ISS GO:0048146 positive regulation of fibroblast proliferation ISS GO:0050769 positive regulation of neurogenesis ISS GO:0051102 DNA ligation involved in DNA recombination ISS GO:0051103 DNA ligation involved in DNA repair IDA GO:0051103 DNA ligation involved in DNA repair ISS GO:0051276 chromosome organization ISS GO:0051301 cell division IEA GO:0051402 neuron apoptosis ISS GO:0071285 cellular response to lithium ion IEA cellular_component GO:0000793 condensed chromosome IDA GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005886 plasma membrane IDA GO:0005925 focal adhesion IDA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IDA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex ISS GO:0032807 DNA ligase IV complex IMP GO:0070419 nonhomologous end joining complex IDA molecular_function GO:0000166 nucleotide binding IEA GO:0003677 DNA binding IDA GO:0003909 DNA ligase activity IDA GO:0003910 DNA ligase (ATP) activity IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IPI GO:0016874 ligase activity IDA GO:0046872 metal ion binding IEA

Protein-protein interaction details for LIG4 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID XRCC4 Two-hybrid physical 17567543 XRCC4 Affinity Capture-Western physical 17567543 NHEJ1 Affinity Capture-Western physical 17567543 PNKP Affinity Capture-MS physical 17353931 ATR Protein-peptide physical 10608806 PRKDC Protein-peptide physical 10608806 ATM Protein-peptide physical 10608806 XRCC4 Co-crystal Structure physical 11702069 XRCC4 Affinity Capture-Western physical 15520013 XRCC6 Affinity Capture-Western physical 15520013 XRCC5 Affinity Capture-Western physical 15520013 APLF Reconstituted Complex physical 17396150 SMC2 Two-hybrid physical 12589063 SMC2 Reconstituted Complex physical 12589063 SMC2 Affinity Capture-Western physical 12589063 XRCC4 Reconstituted Complex physical 11809878