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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LYN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002553 histamine secretion by mast cell IEA GO:0006468 protein phosphorylation TAS GO:0006974 response to DNA damage stimulus IDA GO:0006991 response to sterol depletion IEA GO:0007165 signal transduction TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation ISS GO:0009636 response to toxin IEA GO:0009725 response to hormone stimulus ISS GO:0009743 response to carbohydrate stimulus IEA GO:0010976 positive regulation of neuron projection development IMP GO:0014003 oligodendrocyte development IEA GO:0014070 response to organic cyclic compound IEA GO:0030168 platelet activation TAS GO:0030218 erythrocyte differentiation IEA GO:0030218 erythrocyte differentiation ISS GO:0031175 neuron projection development IEA GO:0031295 T cell costimulation TAS GO:0031668 cellular response to extracellular stimulus IEA GO:0032868 response to insulin stimulus IEA GO:0034605 cellular response to heat IEA GO:0035556 intracellular signal transduction IEA GO:0042327 positive regulation of phosphorylation IEA GO:0042493 response to drug IEA GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS GO:0043200 response to amino acid stimulus IEA GO:0044419 interspecies interaction between organisms IEA GO:0046777 protein autophosphorylation IEA GO:0048678 response to axon injury IEA GO:0050663 cytokine secretion IEA GO:0050853 B cell receptor signaling pathway IEA GO:0050900 leukocyte migration TAS GO:0051272 positive regulation of cellular component movement IDA GO:0051279 regulation of release of sequestered calcium ion into cytosol IEA GO:0060252 positive regulation of glial cell proliferation IEA GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA GO:0070304 positive regulation of stress-activated protein kinase signaling cascade IDA GO:0070447 positive regulation of oligodendrocyte progenitor proliferation IEA GO:0071300 cellular response to retinoic acid IMP cellular_component GO:0005624 membrane fraction IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005634 nucleus ISS GO:0005737 cytoplasm IEA GO:0005737 cytoplasm ISS GO:0005758 mitochondrial intermembrane space IEA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0014069 postsynaptic density IEA GO:0030061 mitochondrial crista IEA GO:0031966 mitochondrial membrane IEA GO:0034666 alpha2-beta1 integrin complex IEA GO:0043231 intracellular membrane-bounded organelle IDA GO:0045121 membrane raft IDA GO:0045121 membrane raft IEA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0004716 receptor signaling protein tyrosine kinase activity TAS GO:0005161 platelet-derived growth factor receptor binding IEA GO:0005178 integrin binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0017124 SH3 domain binding IEA GO:0031625 ubiquitin protein ligase binding IEA GO:0043208 glycosphingolipid binding IEA GO:0044325 ion channel binding IPI GO:0051219 phosphoprotein binding IEA

Protein-protein interaction details for LYN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CSNK2B Two-hybrid physical 14667819 CDK4 Affinity Capture-MS physical 17353931 MUC1 Reconstituted Complex physical 12750561 MUC1 Affinity Capture-Western physical 12750561 INPP5D Affinity Capture-Western physical 12882960 INPP5D Reconstituted Complex physical 12882960 PDE4A Reconstituted Complex physical 10206997 PRAM1 Affinity Capture-Western physical 11301322 CD22 Biochemical Activity physical 10748054 PTPN6 Reconstituted Complex physical 10574931 CDK1 Affinity Capture-Western physical 8051175 CDK1 Affinity Capture-Western physical 8051175 CDK1 Biochemical Activity physical 8051175 UNC119 Reconstituted Complex physical 12496276 UNC119 Affinity Capture-Western physical 12496276 GAB2 Affinity Capture-Western physical 11971018 TEC Affinity Capture-Western physical 11071635 DOK1 Biochemical Activity physical 11071635 DOK1 Reconstituted Complex physical 11071635 SRC Protein-peptide physical 9169421 PTK2B Affinity Capture-Western physical 11311138 SYK Affinity Capture-Western physical 7831290 SYK Reconstituted Complex physical 7831290 CD36 Affinity Capture-Western physical 1715582 MME Affinity Capture-Western physical 8943850 NEDD9 Reconstituted Complex physical 9020138 NEDD9 Affinity Capture-Western physical 9020138 BCAR1 Affinity Capture-Western physical 9020138 PLCG2 Affinity Capture-Western physical 8395016 PLCG2 Reconstituted Complex physical 8395016 LCP2 Affinity Capture-Western physical 10026222 LCP2 Reconstituted Complex physical 10026222 MAPK3 Affinity Capture-Western physical 11131153 GAB3 Reconstituted Complex physical 11739737 JAK2 Reconstituted Complex physical 9573010 EPOR Reconstituted Complex physical 9573010 EPOR Affinity Capture-Western physical 9573010 EPOR Affinity Capture-Western physical 9573010 SKAP2 Affinity Capture-Western physical 9837776 CDK1 Affinity Capture-Western physical 8910336 RPS6KB1 Biochemical Activity physical 16640565 RPS6KB2 Biochemical Activity physical 16640565 KIT Affinity Capture-Western physical 11825908 DOK1 Biochemical Activity physical 11825908 SKAP1 Reconstituted Complex physical 9195899 FCGR2A Affinity Capture-Western physical 9268059 CSF2RB Protein-peptide physical 9973406 BTK Reconstituted Complex physical 8058772 PRKDC Reconstituted Complex physical 9748231 EVL Reconstituted Complex physical 10945997 PPP1R15A Two-hybrid physical 11517336 PPP1R15A Affinity Capture-Western physical 11517336 PPP1R15A Reconstituted Complex physical 11517336 PECAM1 Affinity Capture-Western physical 10858437 PAG1 Reconstituted Complex physical 10790433 TRAT1 Reconstituted Complex physical 10790433 BANK1 Affinity Capture-Western physical 11782428 BANK1 Reconstituted Complex physical 11782428 CBL Affinity Capture-Western physical 12244174 NMT1 Biochemical Activity physical 11594778 TYK2 Reconstituted Complex physical 9633884 CD72 Biochemical Activity physical 9590210 CD22 Affinity Capture-Western physical 10228003 PTK2 Affinity Capture-Western physical 9169439 RPL10 Reconstituted Complex physical 12138090 KIT Affinity Capture-Western physical 9341198 KIT Reconstituted Complex physical 9341198 CD24 Affinity Capture-Western physical 8753773 SHC1 Affinity Capture-Western physical 7650013 HCLS1 Affinity Capture-Western physical 7682714 PPP1R8 Biochemical Activity physical 11104670 PIK3CG Affinity Capture-Western physical 10318860 BCAR1 Affinity Capture-Western physical 9581808 PLCG2 Affinity Capture-Western physical 10981967 PTPRC Affinity Capture-Western physical 7516335 PTPRC Reconstituted Complex physical 7516335 CTLA4 Affinity Capture-Western physical 9712716 CBLC Reconstituted Complex physical 10362357 TRPV4 Biochemical Activity physical 12538589 TRPV4 Affinity Capture-Western physical 12538589 GP6 Reconstituted Complex physical 11943772 GP6 Affinity Capture-Western physical 11943772 CSF3R Affinity Capture-Western physical 8197119 CSF1R Affinity Capture-Western physical 7636265 CSF2RB Affinity Capture-Western physical 7636265 CDK2 Affinity Capture-Western physical 10432313 FCAR Affinity Capture-Western physical 9427690 FASLG Reconstituted Complex physical 17164290 CENPV Reconstituted Complex physical 19930468 CENPV Affinity Capture-Western physical 19930468 UBC Affinity Capture-Western physical 19930468 NDFIP2 Affinity Capture-Western physical 20534535 NDFIP2 Reconstituted Complex physical 20534535 UBC Affinity Capture-Western physical 20534535 UHRF2 Far Western physical 21952639 GP6 Affinity Capture-Western physical 12594225