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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SMAD7 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0001657 ureteric bud development IEA GO:0007179 transforming growth factor beta receptor signaling pathway TAS GO:0010719 negative regulation of epithelial to mesenchymal transition IC GO:0010719 negative regulation of epithelial to mesenchymal transition TAS GO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA GO:0010944 negative regulation of transcription by competitive promoter binding IDA GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IC GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA GO:0022409 positive regulation of cell-cell adhesion IDA GO:0030336 negative regulation of cell migration TAS GO:0030509 BMP signaling pathway TAS GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA GO:0030514 negative regulation of BMP signaling pathway IDA GO:0030514 negative regulation of BMP signaling pathway IEA GO:0031397 negative regulation of protein ubiquitination IDA GO:0031398 positive regulation of protein ubiquitination IDA GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA GO:0032925 regulation of activin receptor signaling pathway IDA GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA GO:0034333 adherens junction assembly IMP GO:0034616 response to laminar fluid shear stress IEP GO:0034629 cellular protein complex localization IDA GO:0035556 intracellular signal transduction IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0045768 positive regulation of anti-apoptosis TAS GO:0045892 negative regulation of transcription, DNA-dependent IEA GO:0048844 artery morphogenesis IEA GO:0048844 artery morphogenesis ISS GO:0050821 protein stabilization IDA GO:0051444 negative regulation of ubiquitin-protein ligase activity IDA GO:0055010 ventricular cardiac muscle tissue morphogenesis IEA GO:0055010 ventricular cardiac muscle tissue morphogenesis ISS GO:0055117 regulation of cardiac muscle contraction IEA GO:0055117 regulation of cardiac muscle contraction ISS GO:0060373 regulation of ventricular cardiomyocyte membrane depolarization IC GO:0060389 pathway-restricted SMAD protein phosphorylation IEA GO:0060389 pathway-restricted SMAD protein phosphorylation ISS GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IDA GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation TAS GO:0060412 ventricular septum morphogenesis IEA GO:0060412 ventricular septum morphogenesis ISS cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005667 transcription factor complex IEA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005813 centrosome IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005913 cell-cell adherens junction IDA GO:0016342 catenin complex IDA GO:0043234 protein complex IEA molecular_function GO:0005515 protein binding IPI GO:0005518 collagen binding IEA GO:0008013 beta-catenin binding IPI GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity IDA GO:0031625 ubiquitin protein ligase binding IPI GO:0034713 type I transforming growth factor beta receptor binding IPI GO:0044212 transcription regulatory region DNA binding IDA GO:0048185 activin binding IPI GO:0070411 I-SMAD binding IPI

Protein-protein interaction details for SMAD7 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PIAS4 Two-hybrid physical 12815042 BMPR1A Affinity Capture-Western physical 15148321 TGFBR1 Affinity Capture-Western physical 15148321 CTNNB1 Affinity Capture-Western physical 15684397 CTNNB1 Co-localization physical 15684397 LEF1 Affinity Capture-Western physical 15684397 TGFBR1 Affinity Capture-Western physical 14722617 SMURF2 Affinity Capture-Western physical 14722617 SMURF1 Affinity Capture-Western physical 14722617 RNF111 Affinity Capture-Western physical 14657019 RNF111 Affinity Capture-Western physical 14657019 TGFBR1 Affinity Capture-Western physical 14657019 PIAS4 Affinity Capture-Western physical 12815042 PARD3B Reconstituted Complex physical 12650946 DVL1 Reconstituted Complex physical 12650946 ERBB2IP Reconstituted Complex physical 12650946 MAPK14 Affinity Capture-Western physical 12589052 MAP2K3 Affinity Capture-Western physical 12589052 MAP2K6 Affinity Capture-Western physical 12589052 MAP3K7 Affinity Capture-Western physical 12589052 TAB1 Affinity Capture-Western physical 12589052 EP300 Affinity Capture-Western physical 12408818 EP300 Reconstituted Complex physical 12408818 EP300 Affinity Capture-Western physical 12408818 EP300 Biochemical Activity physical 12408818 SMURF2 Affinity Capture-Western physical 11163210 TGFBR1 Affinity Capture-Western physical 11163210 TGFBR2 Affinity Capture-Western physical 11163210 TGFBR1 Reconstituted Complex physical 9215638 TGFBR1 Affinity Capture-Western physical 9215638 STAMBP Affinity Capture-Western physical 11483516 AKT1 Affinity Capture-Western physical 16362038 TAB1 Affinity Capture-Western physical 11737269 ACVR1B Affinity Capture-Western physical 12023024 STRAP Phenotypic Enhancement genetic 10757800 STRAP Affinity Capture-Western physical 10757800 STRAP Affinity Capture-Western physical 10757800 TGFBR1 Affinity Capture-Western physical 10757800 SMAD3 Phenotypic Suppression genetic 10757800 SMAD2 Phenotypic Suppression genetic 9892009 SMAD3 Phenotypic Suppression genetic 9892009 SMAD4 Phenotypic Suppression genetic 9892009 YAP1 Two-hybrid physical 12118366 YAP1 Phenotypic Enhancement genetic 12118366 YAP1 Affinity Capture-Western physical 12118366 SMAD6 Two-hybrid physical 9256479 SMAD6 Two-hybrid physical 9256479 SMAD6 Affinity Capture-Western physical 9256479 SMURF2 Affinity Capture-Western physical 18448069 FKBP1A Affinity Capture-Western physical 16720724 FKBP1A Affinity Capture-Western physical 16720724 ACVR1B Affinity Capture-Western physical 16720724 ACVR1B Affinity Capture-Western physical 16720724 SMURF1 Affinity Capture-Western physical 16720724 UBC Affinity Capture-Western physical 16285943 KAT2B Affinity Capture-Western physical 16285943 UCHL5 Reconstituted Complex physical 16027725 UCHL5 Affinity Capture-Western physical 16027725 TGFBR1 Affinity Capture-Western physical 16027725 ITCH Affinity Capture-Western physical 15946939 ITCH Affinity Capture-Western physical 15946939 UBC Affinity Capture-Western physical 15946939 TGFBR1 Affinity Capture-Western physical 15946939 HDAC1 Affinity Capture-Western physical 15831498 HDAC2 Affinity Capture-Western physical 15831498 HDAC3 Affinity Capture-Western physical 15831498 HDAC5 Affinity Capture-Western physical 15831498 HDAC6 Affinity Capture-Western physical 15831498 HDAC1 Reconstituted Complex physical 15831498 HDAC1 Affinity Capture-Western physical 15831498 UBC Affinity Capture-Western physical 15831498 SMAD4 Affinity Capture-Western physical 15817471 SMAD4 Affinity Capture-Western physical 15817471 SMAD4 Reconstituted Complex physical 15817471 NEDD4 Affinity Capture-Western physical 15496141 NEDD4 Affinity Capture-Western physical 15496141 SRF Affinity Capture-Western physical 16690609 SRF Affinity Capture-Western physical 16690609 WWP1 Affinity Capture-Western physical 15221015 SMURF1 Affinity Capture-Western physical 15221015 SMURF2 Affinity Capture-Western physical 15221015 UBC Affinity Capture-Western physical 15221015 HDAC1 Affinity Capture-Western physical 15831516 HDAC2 Affinity Capture-Western physical 15831516 HDAC3 Affinity Capture-Western physical 15831516 HDAC5 Affinity Capture-Western physical 15831516 HDAC6 Affinity Capture-Western physical 15831516 SMAD2 Reconstituted Complex physical 17438144 SMAD4 Reconstituted Complex physical 17438144 SMURF1 Affinity Capture-Western physical 11278251 SMURF1 Affinity Capture-Western physical 11278251 UBC Affinity Capture-Western physical 11278251 TGFBR1 Affinity Capture-Western physical 17314099 STRAP Affinity Capture-Western physical 17314099 SIRT1 Affinity Capture-Western physical 17098745 SIRT1 Affinity Capture-Western physical 17098745 SIRT1 Reconstituted Complex physical 17098745 UBC Affinity Capture-Western physical 17098745 ZEB1 Affinity Capture-Western physical 20514018 ZEB1 Affinity Capture-Western physical 20514018 ZEB1 Reconstituted Complex physical 20514018 TSC22D1 Affinity Capture-Western physical 21791611 TSC22D1 Affinity Capture-Western physical 21791611 TGFBR1 Affinity Capture-Western physical 21791611 SMURF2 Affinity Capture-Western physical 20937913 SMURF2 Reconstituted Complex physical 20937913 SMURF2 Co-crystal Structure physical 20937913 WWP2 Affinity Capture-Western physical 21258410 WWP2 Affinity Capture-Western physical 21258410 UBC Affinity Capture-Western physical 21258410 WWP2 Biochemical Activity physical 21258410