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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MC4R (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002024 diet induced thermogenesis IEA GO:0006112 energy reserve metabolic process IEA GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger TAS GO:0007631 feeding behavior IEA GO:0019222 regulation of metabolic process IEA GO:0030073 insulin secretion IEA GO:0030819 positive regulation of cAMP biosynthetic process IDA GO:0032868 response to insulin stimulus IEA GO:0045780 positive regulation of bone resorption IMP cellular_component GO:0005886 plasma membrane TAS GO:0016021 integral to membrane IEA molecular_function GO:0004871 signal transducer activity IEA GO:0004872 receptor activity IEA GO:0004930 G-protein coupled receptor activity IEA GO:0004977 melanocortin receptor activity TAS GO:0004980 melanocyte-stimulating hormone receptor activity IPI GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA GO:0031625 ubiquitin protein ligase binding IPI GO:0042923 neuropeptide binding IPI

Protein-protein interaction details for MC4R (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ATRNL1 Two-hybrid physical 14531729 AGRP Reconstituted Complex physical 12815165 AGRP Reconstituted Complex physical 10318826 POMC Reconstituted Complex physical 11101306 POMC Reconstituted Complex physical 9058374 MGRN1 Affinity Capture-Western physical 19737927