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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MAP3K1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000209 protein polyubiquitination IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0006468 protein phosphorylation IDA GO:0006468 protein phosphorylation NAS GO:0006468 protein phosphorylation TAS GO:0006970 response to osmotic stress IEA GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0007256 activation of JNKK activity IEA GO:0007257 activation of JUN kinase activity IEA GO:0008063 Toll signaling pathway TAS GO:0008637 apoptotic mitochondrial changes IEA GO:0018105 peptidyl-serine phosphorylation IEA GO:0030334 regulation of cell migration IEA GO:0030838 positive regulation of actin filament polymerization IEA GO:0032232 negative regulation of actin filament bundle assembly IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042060 wound healing IEA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA GO:0043010 camera-type eye development IEA GO:0043065 positive regulation of apoptosis IEA GO:0045087 innate immune response TAS GO:0046777 protein autophosphorylation IEA GO:0050434 positive regulation of viral transcription IEA GO:0051259 protein oligomerization IEA GO:0071260 cellular response to mechanical stimulus IEP cellular_component GO:0005624 membrane fraction IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IDA GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity IEA GO:0004706 JUN kinase kinase kinase activity IEA GO:0004709 MAP kinase kinase kinase activity NAS GO:0004710 MAP/ERK kinase kinase activity IEA GO:0004842 ubiquitin-protein ligase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding NAS GO:0008270 zinc ion binding IEA GO:0008432 JUN kinase binding IEA GO:0008545 JUN kinase kinase activity IEA GO:0019901 protein kinase binding IPI GO:0031434 mitogen-activated protein kinase kinase binding IEA GO:0042802 identical protein binding IEA GO:0046625 sphingolipid binding IEA GO:0046872 metal ion binding IEA GO:0051019 mitogen-activated protein kinase binding IEA

Protein-protein interaction details for MAP3K1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CDC37 Affinity Capture-MS physical 14743216 FKBP5 Affinity Capture-MS physical 14743216 DCAF7 Affinity Capture-MS physical 14743216 HSP90AA2 Affinity Capture-MS physical 14743216 RPL30 Affinity Capture-MS physical 14743216 RPL4 Affinity Capture-MS physical 14743216 RPS13 Affinity Capture-MS physical 14743216 MAPK8 Affinity Capture-Western physical 9405400 MAPK8 Reconstituted Complex physical 9405400 MAPK8 Biochemical Activity physical 9405400 MAPK8 Affinity Capture-Western physical 9405400 YWHAE Reconstituted Complex physical 9452471 MAP4K2 Reconstituted Complex physical 9712898 AXIN1 Affinity Capture-Western physical 11884395 MAP4K4 Affinity Capture-Western physical 9135144 DVL2 Affinity Capture-Western physical 10829020 AXIN1 Affinity Capture-Western physical 10829020 AXIN1 Affinity Capture-Western physical 10829020 UBE2I Two-hybrid physical 9563508 UBE2I Reconstituted Complex physical 9563508 MAPK8IP3 Affinity Capture-Western physical 10523642 RAF1 Affinity Capture-Western physical 10969079 RAF1 Affinity Capture-Western physical 10969079 RAF1 Reconstituted Complex physical 10969079 MAP2K1 Affinity Capture-Western physical 10969079 MAPK1 Affinity Capture-Western physical 10969079 MAP2K1 Affinity Capture-Western physical 10969079 MAPK1 Affinity Capture-Western physical 10969079 GRB2 Reconstituted Complex physical 9733714 GRB2 Affinity Capture-Western physical 9733714 TRAF2 Co-fractionation physical 10346818 TRAF2 Affinity Capture-Western physical 10346818 MAP2K4 Affinity Capture-Western physical 10713157 IKBKB Biochemical Activity physical 11057907 ALK Affinity Capture-MS physical 14968112 ALK Affinity Capture-Western physical 14968112 UBE2D1 Two-hybrid physical 19690564 UBE2D2 Two-hybrid physical 19690564 UBE2D3 Two-hybrid physical 19690564 UBE2D4 Two-hybrid physical 19690564 UBE2E1 Two-hybrid physical 19690564 UBE2L6 Two-hybrid physical 19690564 UBE2W Two-hybrid physical 19690564 DTX1 Affinity Capture-Western physical 15684388 DTX1 Reconstituted Complex physical 15684388 UBC Affinity Capture-Western physical 15684388