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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NF1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade ISS GO:0001649 osteoblast differentiation ISS GO:0001656 metanephros development ISS GO:0001666 response to hypoxia ISS GO:0001889 liver development ISS GO:0001937 negative regulation of endothelial cell proliferation IMP GO:0001938 positive regulation of endothelial cell proliferation IEA GO:0001952 regulation of cell-matrix adhesion ISS GO:0006469 negative regulation of protein kinase activity ISS GO:0007154 cell communication ISS GO:0007165 signal transduction IEA GO:0007265 Ras protein signal transduction ISS GO:0007406 negative regulation of neuroblast proliferation ISS GO:0007420 brain development ISS GO:0007422 peripheral nervous system development ISS GO:0007507 heart development ISS GO:0007519 skeletal muscle tissue development IEA GO:0008542 visual learning ISS GO:0014044 Schwann cell development ISS GO:0014065 phosphatidylinositol 3-kinase cascade ISS GO:0016525 negative regulation of angiogenesis IEA GO:0021510 spinal cord development ISS GO:0021897 forebrain astrocyte development ISS GO:0021915 neural tube development IEA GO:0021987 cerebral cortex development ISS GO:0022011 myelination in peripheral nervous system ISS GO:0030036 actin cytoskeleton organization ISS GO:0030198 extracellular matrix organization ISS GO:0030199 collagen fibril organization ISS GO:0030325 adrenal gland development ISS GO:0030336 negative regulation of cell migration IMP GO:0032228 regulation of synaptic transmission, GABAergic IEA GO:0032318 regulation of Ras GTPase activity IMP GO:0032320 positive regulation of Ras GTPase activity IDA GO:0032320 positive regulation of Ras GTPase activity IMP GO:0032320 positive regulation of Ras GTPase activity ISS GO:0035021 negative regulation of Rac protein signal transduction IEA GO:0042060 wound healing ISS GO:0042992 negative regulation of transcription factor import into nucleus ISS GO:0043065 positive regulation of apoptosis ISS GO:0043407 negative regulation of MAP kinase activity ISS GO:0043409 negative regulation of MAPKKK cascade IMP GO:0043409 negative regulation of MAPKKK cascade ISS GO:0043473 pigmentation ISS GO:0043525 positive regulation of neuron apoptosis ISS GO:0043535 regulation of blood vessel endothelial cell migration IMP GO:0045124 regulation of bone resorption ISS GO:0045685 regulation of glial cell differentiation ISS GO:0045762 positive regulation of adenylate cyclase activity ISS GO:0045765 regulation of angiogenesis IMP GO:0046580 negative regulation of Ras protein signal transduction IBA GO:0046929 negative regulation of neurotransmitter secretion IEA GO:0048147 negative regulation of fibroblast proliferation IEA GO:0048169 regulation of long-term neuronal synaptic plasticity IEA GO:0048485 sympathetic nervous system development ISS GO:0048593 camera-type eye morphogenesis ISS GO:0048712 negative regulation of astrocyte differentiation IEA GO:0048715 negative regulation of oligodendrocyte differentiation ISS GO:0048745 smooth muscle tissue development ISS GO:0048844 artery morphogenesis ISS GO:0048853 forebrain morphogenesis ISS GO:0050890 cognition IMP GO:0051056 regulation of small GTPase mediated signal transduction IEA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus ISS GO:0005737 cytoplasm IBA GO:0005737 cytoplasm ISS GO:0030424 axon IDA GO:0030425 dendrite IDA GO:0031235 intrinsic to internal side of plasma membrane IBA molecular_function GO:0005099 Ras GTPase activator activity IDA GO:0005515 protein binding IPI

Protein-protein interaction details for NF1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MYOG Reconstituted Complex physical 1329097 HRAS Two-hybrid physical 8628317 SMARCA4 Affinity Capture-Western physical 15999204 POLR2A Affinity Capture-Western physical 15999204 POLR2A Affinity Capture-Western physical 15999204 SMARCA4 Affinity Capture-Western physical 15999204 SMAD4 Affinity Capture-Western physical 18215124 SMAD2 Reconstituted Complex physical 18215124 SMAD3 Reconstituted Complex physical 18215124 SMAD4 Reconstituted Complex physical 18215124 TIRAP Affinity Capture-MS physical 21903422