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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NOS2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001666 response to hypoxia IEA GO:0001912 positive regulation of leukocyte mediated cytotoxicity TAS GO:0002227 innate immune response in mucosa NAS GO:0006527 arginine catabolic process IDA GO:0006801 superoxide metabolic process ISS GO:0006809 nitric oxide biosynthetic process IDA GO:0006809 nitric oxide biosynthetic process IEA GO:0007596 blood coagulation TAS GO:0018119 peptidyl-cysteine S-nitrosylation ISS GO:0030168 platelet activation TAS GO:0042127 regulation of cell proliferation IEA GO:0042177 negative regulation of protein catabolic process IEA GO:0042742 defense response to bacterium IMP GO:0042742 defense response to bacterium ISS GO:0043457 regulation of cellular respiration TAS GO:0050796 regulation of insulin secretion IMP GO:0050829 defense response to Gram-negative bacterium NAS GO:0051712 positive regulation of killing of cells of other organism IMP GO:0071222 cellular response to lipopolysaccharide IEA GO:0071346 cellular response to interferon-gamma IEA cellular_component GO:0005622 intracellular IDA GO:0005634 nucleus ISS GO:0005737 cytoplasm IDA GO:0005829 cytosol IMP GO:0005829 cytosol TAS GO:0030863 cortical cytoskeleton IEA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0004517 nitric-oxide synthase activity IDA GO:0004517 nitric-oxide synthase activity IEA GO:0005515 protein binding IPI GO:0005516 calmodulin binding IEA GO:0010181 FMN binding IEA GO:0010181 FMN binding ISS GO:0016491 oxidoreductase activity IEA GO:0020037 heme binding ISS GO:0034617 tetrahydrobiopterin binding ISS GO:0034618 arginine binding ISS GO:0042803 protein homodimerization activity ISS GO:0046872 metal ion binding IEA GO:0050660 flavin adenine dinucleotide binding ISS GO:0050661 NADP binding TAS

Protein-protein interaction details for NOS2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CAV1 Co-fractionation physical 11114180 CAV1 Reconstituted Complex physical 11114180 SLC9A3R1 Reconstituted Complex physical 12080081 RAC2 Affinity Capture-Western physical 11457725 RAC2 Affinity Capture-Western physical 11457725 RAC1 Reconstituted Complex physical 11457725 RAC2 Reconstituted Complex physical 11457725 SPSB1 Affinity Capture-Western physical 21199876 SPSB4 Affinity Capture-Western physical 21199876 SPSB1 Affinity Capture-Western physical 21199876 SPSB4 Affinity Capture-Western physical 21199876 SPSB1 Co-localization physical 21199876 UBC Affinity Capture-Western physical 21199876 SPSB2 Affinity Capture-Western physical 21199876 TCEB1 Affinity Capture-Western physical 21199876 CUL5 Affinity Capture-Western physical 21199876 TCEB1 Affinity Capture-Western physical 21199876 SPSB2 Affinity Capture-Western physical 21199876 SPSB2 Affinity Capture-Western physical 21549100 SPSB2 Reconstituted Complex physical 21549100 SPSB2 Affinity Capture-Western physical 21549100 SPSB1 Affinity Capture-Western physical 21549100 SPSB1 Affinity Capture-Western physical 21549100 UBC Affinity Capture-Western physical 21549100 UBC Affinity Capture-Western physical 19376148 UBC Affinity Capture-Western physical 20634424 UCHL5 Affinity Capture-Western physical 20634424 UBC Affinity Capture-Western physical 21094287 SPSB2 Reconstituted Complex physical 20603330 SPSB2 Affinity Capture-Western physical 20603330 SPSB4 Reconstituted Complex physical 20603330 SPSB1 Reconstituted Complex physical 20603330 CUL5 Biochemical Activity physical 20603330 RNF7 Biochemical Activity physical 20603330