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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NOS3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001542 ovulation from ovarian follicle IEA GO:0001666 response to hypoxia IEA GO:0001701 in utero embryonic development IEA GO:0001974 blood vessel remodeling IEA GO:0001974 blood vessel remodeling ISS GO:0002028 regulation of sodium ion transport IEA GO:0003100 regulation of systemic arterial blood pressure by endothelin IMP GO:0006527 arginine catabolic process IDA GO:0006809 nitric oxide biosynthetic process IDA GO:0006809 nitric oxide biosynthetic process IEA GO:0006916 anti-apoptosis ISS GO:0007005 mitochondrion organization ISS GO:0007165 signal transduction IEA GO:0007568 aging IEA GO:0007596 blood coagulation TAS GO:0008217 regulation of blood pressure NAS GO:0008285 negative regulation of cell proliferation ISS GO:0009408 response to heat NAS GO:0009612 response to mechanical stimulus IEA GO:0010288 response to lead ion IEA GO:0010544 negative regulation of platelet activation NAS GO:0014070 response to organic cyclic compound IEA GO:0014740 negative regulation of muscle hyperplasia IEA GO:0014740 negative regulation of muscle hyperplasia ISS GO:0014806 smooth muscle hyperplasia IEA GO:0014806 smooth muscle hyperplasia ISS GO:0030168 platelet activation TAS GO:0030324 lung development IEA GO:0031284 positive regulation of guanylate cyclase activity IMP GO:0031284 positive regulation of guanylate cyclase activity ISS GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032355 response to estradiol stimulus IEA GO:0032496 response to lipopolysaccharide IEA GO:0034097 response to cytokine stimulus IEA GO:0034405 response to fluid shear stress IEP GO:0042493 response to drug IEA GO:0043065 positive regulation of apoptosis IEA GO:0043200 response to amino acid stimulus IEA GO:0043267 negative regulation of potassium ion transport IEA GO:0043434 response to peptide hormone stimulus IEA GO:0043542 endothelial cell migration IMP GO:0045471 response to ethanol IEA GO:0045766 positive regulation of angiogenesis IEA GO:0045766 positive regulation of angiogenesis ISS GO:0045909 positive regulation of vasodilation NAS GO:0046209 nitric oxide metabolic process TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050880 regulation of blood vessel size IEA GO:0050880 regulation of blood vessel size ISS GO:0050880 regulation of blood vessel size NAS GO:0050999 regulation of nitric-oxide synthase activity TAS GO:0051346 negative regulation of hydrolase activity IEA GO:0051926 negative regulation of calcium ion transport IEA GO:0055093 response to hyperoxia IEA GO:0055094 response to lipoprotein stimulus IEA GO:0071560 cellular response to transforming growth factor beta stimulus IEA cellular_component GO:0000139 Golgi membrane TAS GO:0005625 soluble fraction IEA GO:0005634 nucleus IEA GO:0005634 nucleus ISS GO:0005730 nucleolus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005794 Golgi apparatus IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane TAS GO:0005901 caveola IDA GO:0030666 endocytic vesicle membrane TAS GO:0045177 apical part of cell IEA molecular_function GO:0003785 actin monomer binding IPI GO:0004517 nitric-oxide synthase activity IDA GO:0004517 nitric-oxide synthase activity IEA GO:0005506 iron ion binding IEA GO:0005515 protein binding IPI GO:0005516 calmodulin binding IEA GO:0010181 FMN binding IEA GO:0010181 FMN binding NAS GO:0016491 oxidoreductase activity IEA GO:0020037 heme binding IDA GO:0020037 heme binding IEA GO:0034617 tetrahydrobiopterin binding IDA GO:0034618 arginine binding IDA GO:0046870 cadmium ion binding NAS GO:0046872 metal ion binding IEA GO:0050660 flavin adenine dinucleotide binding IEA GO:0050660 flavin adenine dinucleotide binding NAS GO:0050661 NADP binding IEA GO:0050661 NADP binding NAS

Protein-protein interaction details for NOS3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID HSP90AA1 Affinity Capture-Western physical 12676772 HSP90AA1 Affinity Capture-Western physical 12676772 GUCY1B3 Reconstituted Complex physical 12676772 GUCY1B3 Affinity Capture-Western physical 12676772 GUCY1B3 Affinity Capture-Western physical 12676772 CAV1 Affinity Capture-Western physical 8910295 CAV1 Affinity Capture-Western physical 8910295 NOSTRIN Two-hybrid physical 12446846 NOSTRIN Two-hybrid physical 12446846 NOSTRIN Affinity Capture-Western physical 12446846 NOSTRIN Affinity Capture-Western physical 12446846 NOSTRIN Reconstituted Complex physical 12446846 NOSTRIN Co-localization physical 12446846 HSP90AA1 Affinity Capture-Western physical 11744239 HSP90AA1 Reconstituted Complex physical 11744239 HSP90AA1 Affinity Capture-Western physical 12124224 CALM1 Affinity Capture-Western physical 20705923 CALM1 Affinity Capture-Western physical 20705923 HDAC3 Affinity Capture-Western physical 20705923 CALM1 Affinity Capture-Western physical 11397791 CAMK2A Affinity Capture-Western physical 11397791 HSP90AA1 Two-hybrid physical 11988487 HSP90AA1 Reconstituted Complex physical 11988487