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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for NOTCH1 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
ISS
GO:0001701
in utero embryonic development
IEA
GO:0001708
cell fate specification
IEA
GO:0001889
liver development
IEA
GO:0002040
sprouting angiogenesis
IEA
GO:0002052
positive regulation of neuroblast proliferation
IEA
GO:0003180
aortic valve morphogenesis
IMP
GO:0003264
regulation of cardioblast proliferation
IEA
GO:0006355
regulation of transcription, DNA-dependent
TAS
GO:0006955
immune response
NAS
GO:0007219
Notch signaling pathway
IMP
GO:0007219
Notch signaling pathway
TAS
GO:0007220
Notch receptor processing
TAS
GO:0007221
positive regulation of transcription of Notch receptor target
IEA
GO:0007283
spermatogenesis
IEA
GO:0007368
determination of left/right symmetry
IEA
GO:0007386
compartment pattern specification
IEA
GO:0007409
axonogenesis
IEA
GO:0007440
foregut morphogenesis
IEA
GO:0007492
endoderm development
IEA
GO:0007507
heart development
IMP
GO:0008284
positive regulation of cell proliferation
IDA
GO:0009790
embryo development
IEA
GO:0010467
gene expression
TAS
GO:0010718
positive regulation of epithelial to mesenchymal transition
IMP
GO:0010812
negative regulation of cell-substrate adhesion
IDA
GO:0014807
regulation of somitogenesis
IEA
GO:0021515
cell differentiation in spinal cord
IEA
GO:0021915
neural tube development
IEA
GO:0030324
lung development
IEA
GO:0030513
positive regulation of BMP signaling pathway
ISS
GO:0030514
negative regulation of BMP signaling pathway
ISS
GO:0030900
forebrain development
IEA
GO:0031069
hair follicle morphogenesis
IEA
GO:0031100
organ regeneration
IEA
GO:0031960
response to corticosteroid stimulus
IEA
GO:0032496
response to lipopolysaccharide
IEA
GO:0035116
embryonic hindlimb morphogenesis
IEA
GO:0042246
tissue regeneration
IEA
GO:0042640
anagen
IEA
GO:0043065
positive regulation of apoptosis
IEA
GO:0043066
negative regulation of apoptosis
IEA
GO:0045603
positive regulation of endothelial cell differentiation
IEA
GO:0045618
positive regulation of keratinocyte differentiation
IEA
GO:0045662
negative regulation of myoblast differentiation
IMP
GO:0045668
negative regulation of osteoblast differentiation
ISS
GO:0045892
negative regulation of transcription, DNA-dependent
ISS
GO:0045893
positive regulation of transcription, DNA-dependent
ISS
GO:0045955
negative regulation of calcium ion-dependent exocytosis
IEA
GO:0046427
positive regulation of JAK-STAT cascade
ISS
GO:0046533
negative regulation of photoreceptor cell differentiation
IEA
GO:0048103
somatic stem cell division
IEA
GO:0048663
neuron fate commitment
IEA
GO:0048711
positive regulation of astrocyte differentiation
ISS
GO:0048715
negative regulation of oligodendrocyte differentiation
ISS
GO:0048754
branching morphogenesis of a tube
IEA
GO:0050679
positive regulation of epithelial cell proliferation
IEA
GO:0050767
regulation of neurogenesis
IEA
GO:0050793
regulation of developmental process
IEA
GO:0060253
negative regulation of glial cell proliferation
ISS
GO:0060528
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
IEA
GO:0060548
negative regulation of cell death
IEA
GO:0060740
prostate gland epithelium morphogenesis
IEA
GO:0060768
regulation of epithelial cell proliferation involved in prostate gland development
IEA
GO:0097150
neuronal stem cell maintenance
IEP
GO:2000737
negative regulation of stem cell differentiation
IMP
GO:2000974
negative regulation of pro-B cell differentiation
ISS
cellular_component
GO:0001669
acrosomal vesicle
IEA
GO:0002193
MAML1-RBP-Jkappa- ICN1 complex
IDA
GO:0005576
extracellular region
TAS
GO:0005634
nucleus
TAS
GO:0005654
nucleoplasm
TAS
GO:0005737
cytoplasm
IEA
GO:0005788
endoplasmic reticulum lumen
TAS
GO:0005794
Golgi apparatus
IEA
GO:0005796
Golgi lumen
TAS
GO:0005829
cytosol
TAS
GO:0005886
plasma membrane
TAS
GO:0016021
integral to membrane
NAS
molecular_function
GO:0001047
core promoter binding
ISS
GO:0003700
sequence-specific DNA binding transcription factor activity
IEA
GO:0004872
receptor activity
IEA
GO:0005509
calcium ion binding
IEA
GO:0005515
protein binding
IPI
GO:0031490
chromatin DNA binding
IEA
GO:0043565
sequence-specific DNA binding
IEA
Protein-protein interaction details for NOTCH1 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
SMAD3
Reconstituted Complex
physical
14638857
SMAD3
Affinity Capture-Western
physical
14638857
LCK
Affinity Capture-Western
physical
14583609
LCK
Affinity Capture-Western
physical
14583609
PIK3CA
Affinity Capture-Western
physical
14583609
CNTN1
Affinity Capture-Western
physical
14567914
YY1
Affinity Capture-Western
physical
12913000
YY1
Affinity Capture-Western
physical
12913000
YY1
Reconstituted Complex
physical
12913000
RBPJ
Reconstituted Complex
physical
12644465
DTX1
Affinity Capture-Western
physical
11564735
SNW1
Reconstituted Complex
physical
11404076
SNW1
Two-hybrid
physical
11404076
NOTCH3
Phenotypic Suppression
genetic
11404076
XRCC6
Two-hybrid
physical
16169070
RELA
Affinity Capture-Western
physical
8642313
NFKB1
Affinity Capture-Western
physical
8642313
NFKB1
Reconstituted Complex
physical
8642313
DLL1
Reconstituted Complex
physical
11006133
JAG1
Reconstituted Complex
physical
11006133
JAG2
Reconstituted Complex
physical
11006133
LEF1
Reconstituted Complex
physical
11604490
NUMB
Reconstituted Complex
physical
8755477
GSK3B
Biochemical Activity
physical
12123574
GSK3B
Reconstituted Complex
physical
12123574
NOTCH1
Affinity Capture-Western
physical
10669757
NFKB1
Reconstituted Complex
physical
11418662
MAML1
Reconstituted Complex
physical
11101851
MAML1
Affinity Capture-Western
physical
11101851
NOV
Affinity Capture-Western
physical
12050162
NOV
Affinity Capture-Western
physical
12050162
NOV
Reconstituted Complex
physical
12050162
PSEN1
Affinity Capture-Western
physical
10077672
FBXW7
Affinity Capture-Western
physical
11425854
MAML1
Two-hybrid
physical
12370315
MAML2
Two-hybrid
physical
12370315
MAML3
Two-hybrid
physical
12370315
RBPJ
Reconstituted Complex
physical
9111040
RBPJ
Affinity Capture-Western
physical
9111040
SNW1
Affinity Capture-Western
physical
10713164
UBC
Affinity Capture-Western
physical
18628966
UBC
Affinity Capture-Western
physical
18628966
FBXW7
Affinity Capture-Western
physical
17646408
FBXW7
Affinity Capture-Western
physical
17646408
UBC
Affinity Capture-Western
physical
17646408
UBC
Affinity Capture-Western
physical
17575125
EP300
Affinity Capture-Western
physical
19838210
AKT1
Biochemical Activity
physical
18440314
UBC
Affinity Capture-Western
physical
11777909
CBL
Affinity Capture-Western
physical
11777909
UBC
Affinity Capture-Western
physical
10940313
ITCH
Affinity Capture-Western
physical
10940313
ITCH
Affinity Capture-Western
physical
10940313
CTNNB1
Affinity Capture-Western
physical
19000719
CTNNB1
Affinity Capture-Western
physical
19000719
CTNNB1
Reconstituted Complex
physical
19000719
UBC
Affinity Capture-Western
physical
19000719
DTX1
Affinity Capture-Western
physical
20208568
UBC
Affinity Capture-Western
physical
20208568
JAG1
Co-localization
physical
20720151
SNW1
Reconstituted Complex
physical
15546612
CACNA1A
Two-hybrid
physical
21078624
UBC
Reconstituted Complex
physical
19850743
SNAI1
Affinity Capture-MS
physical
22128911
SNAI1
Affinity Capture-Western
physical
22128911
SNAI1
Affinity Capture-Western
physical
22128911
SNAI1
Reconstituted Complex
physical
22128911
MDM2
Affinity Capture-Western
physical
22128911
MDM2
Affinity Capture-Western
physical
22128911