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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SHANK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006461 protein complex assembly ISS GO:0007016 cytoskeletal anchoring at plasma membrane NAS GO:0007399 nervous system development IEA GO:0007616 long-term memory ISS GO:0008306 associative learning ISS GO:0030154 cell differentiation IEA GO:0035418 protein localization to synapse ISS GO:0050885 neuromuscular process controlling balance ISS GO:0060997 dendritic spine morphogenesis ISS GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS GO:2000463 positive regulation of excitatory postsynaptic membrane potential ISS cellular_component GO:0005622 intracellular NAS GO:0005624 membrane fraction IDA GO:0005737 cytoplasm IEA GO:0005886 plasma membrane IEA GO:0014069 postsynaptic density ISS GO:0030054 cell junction IEA GO:0030425 dendrite NAS GO:0045211 postsynaptic membrane IEA GO:0060076 excitatory synapse ISS molecular_function GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IEA GO:0017124 SH3 domain binding ISS GO:0030160 GKAP/Homer scaffold activity ISS GO:0031877 somatostatin receptor binding IEA GO:0035255 ionotropic glutamate receptor binding ISS GO:0042802 identical protein binding ISS GO:0071532 ankyrin repeat binding ISS GO:0097110 scaffold protein binding ISS

Protein-protein interaction details for SHANK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DNM2 Two-hybrid physical 11583995 ARHGEF7 Two-hybrid physical 12626503 DLGAP1 Co-crystal Structure physical 12954649 SHANK1 Co-crystal Structure physical 12954649 ARHGEF7 Affinity Capture-Western physical 12626503 ARHGEF7 Reconstituted Complex physical 12626503 BAIAP2 Two-hybrid physical 12504591 BAIAP2 Far Western physical 12504591 BAIAP2 Affinity Capture-Western physical 12504591 SSTR2 Reconstituted Complex physical 10551867 SSTR2 Affinity Capture-Western physical 10551867 Sharpin Two-hybrid physical 11178875 Sharpin Affinity Capture-Western physical 11178875 SPTAN1 Reconstituted Complex physical 11509555 SPTAN1 Affinity Capture-Western physical 11509555 DNM2 Affinity Capture-Western physical 11583995 DNM2 Reconstituted Complex physical 11583995 LPHN2 Two-hybrid physical 10964907 BAI2 Two-hybrid physical 10964907 STAT1 Two-hybrid physical 20936779