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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for INSIG2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006641 triglyceride metabolic process IEA GO:0006695 cholesterol biosynthetic process IEA GO:0006991 response to sterol depletion IEA GO:0008202 steroid metabolic process IEA GO:0010894 negative regulation of steroid biosynthetic process IEA GO:0030967 ER-nuclear sterol response pathway IDA GO:0032868 response to insulin stimulus IEA GO:0042472 inner ear morphogenesis IEA GO:0042474 middle ear morphogenesis IEA GO:0045717 negative regulation of fatty acid biosynthetic process IEA GO:0060021 palate development IEA GO:0060363 cranial suture morphogenesis IEA GO:0070542 response to fatty acid IEA cellular_component GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0032937 SREBP-SCAP-Insig complex IDA molecular_function GO:0005515 protein binding IPI GO:0008134 transcription factor binding IEA

Protein-protein interaction details for INSIG2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SCAP Affinity Capture-Western physical 16549805 UBC Affinity Capture-Western physical 16549805 UBC Affinity Capture-Western physical 19815544 AMFR Affinity Capture-Western physical 19815544 UBQLN2 Affinity Capture-MS physical 19815544 UBQLN1 Affinity Capture-MS physical 19815544 VCP Affinity Capture-MS physical 19815544 RPN1 Affinity Capture-MS physical 19815544 PSMC5 Affinity Capture-MS physical 19815544 BAT3 Affinity Capture-MS physical 19815544 ADRM1 Affinity Capture-MS physical 19815544 PSMD14 Affinity Capture-MS physical 19815544 PSMD11 Affinity Capture-MS physical 19815544 HSPA8 Affinity Capture-MS physical 19815544 HSPA5 Affinity Capture-MS physical 19815544 PSMD13 Affinity Capture-MS physical 19815544 DSP Affinity Capture-MS physical 19815544 JUP Affinity Capture-MS physical 19815544 ENO1 Affinity Capture-MS physical 19815544 LGALS7 Affinity Capture-MS physical 19815544 PSMD4 Affinity Capture-MS physical 19815544 PSMC2 Affinity Capture-MS physical 19815544 PSMC6 Affinity Capture-MS physical 19815544 PSMB3 Affinity Capture-MS physical 19815544 PSMA2 Affinity Capture-MS physical 19815544 PSMD12 Affinity Capture-MS physical 19815544 FAF2 Affinity Capture-MS physical 19815544 HSPA1A Affinity Capture-MS physical 19815544 HSPA6 Affinity Capture-MS physical 19815544 PSMC3 Reconstituted Complex physical 19815544 PSMC5 Reconstituted Complex physical 19815544 PSMA7 Reconstituted Complex physical 19815544 PSMB1 Reconstituted Complex physical 19815544 VCP Reconstituted Complex physical 19815544 INSIG1 Affinity Capture-Western physical 19617589 RNF139 Affinity Capture-Western physical 22143767