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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PF4 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0002576platelet degranulationTAS
GO:0006935chemotaxisIEA
GO:0006955immune responseIEA
GO:0007596blood coagulationTAS
GO:0010628positive regulation of gene expressionIDA
GO:0010744positive regulation of macrophage derived foam cell differentiationIDA
GO:0016525negative regulation of angiogenesisIDA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030168platelet activationIDA
GO:0030168platelet activationTAS
GO:0030595leukocyte chemotaxisIDA
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0043066negative regulation of apoptosisIDA
GO:0045347negative regulation of MHC class II biosynthetic processIDA
GO:0045651positive regulation of macrophage differentiationIDA
GO:0045653negative regulation of megakaryocyte differentiationIDA
GO:0045918negative regulation of cytolysisIDA
cellular_component
GO:0005576extracellular regionIC
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0031093platelet alpha granule lumenTAS
molecular_function
GO:0008009chemokine activityTAS
GO:0008201heparin bindingIDA

Protein-protein interaction details for PF4 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
CXCR3Reconstituted Complexphysical12782716
THBDReconstituted Complexphysical9395524
PROCReconstituted Complexphysical9395524
PF4Co-crystal Structurephysical8031770
LDLRReconstituted Complexphysical11986215
PF4Co-crystal Structurephysical7547867
CXCL12Reconstituted Complexphysical10233851
PF4Reconstituted Complexphysical7835432
VCANReconstituted Complexphysical11083865