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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PIK3CA (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001525 angiogenesis IEA GO:0006006 glucose metabolic process IEA GO:0006468 protein phosphorylation IEA GO:0006916 anti-apoptosis IEA GO:0007165 signal transduction IEA GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007596 blood coagulation TAS GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0030168 platelet activation TAS GO:0031295 T cell costimulation TAS GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA GO:0040014 regulation of multicellular organism growth IEA GO:0043491 protein kinase B signaling cascade IEA GO:0044029 hypomethylation of CpG island IEA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling IEA GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS cellular_component GO:0005829 cytosol TAS GO:0005942 phosphatidylinositol 3-kinase complex IEA GO:0030027 lamellipodium IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004428 inositol or phosphatidylinositol kinase activity IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016303 1-phosphatidylinositol-3-kinase activity IDA GO:0016303 1-phosphatidylinositol-3-kinase activity IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor IEA GO:0030295 protein kinase activator activity IEA GO:0043560 insulin receptor substrate binding IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS

Protein-protein interaction details for PIK3CA (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PIK3R3 Two-hybrid physical 9415396 CBL Co-purification physical 8641358 ATR Protein-peptide physical 10608806 RASGRP3 Biochemical Activity physical 15213298 HRAS Reconstituted Complex physical 14724584 RASD2 Reconstituted Complex physical 14724584 LCK Affinity Capture-Western physical 14583609 NOTCH1 Affinity Capture-Western physical 14583609 SLC9A3R2 Reconstituted Complex physical 12954600 SLC9A3R1 Reconstituted Complex physical 12954600 ADAP1 Reconstituted Complex physical 12893243 ADAP1 Biochemical Activity physical 12893243 DGKZ Biochemical Activity physical 12890670 DGKZ Affinity Capture-Western physical 12890670 ARHGEF1 Affinity Capture-Western physical 12754211 ARHGEF1 Affinity Capture-Western physical 12754211 GNAQ Affinity Capture-Western physical 12704201 KRAS Two-hybrid physical 10783161 HRAS Two-hybrid physical 10783161 PIK3R1 Reconstituted Complex physical 7929193 IRS1 Affinity Capture-Western physical 16354680 LCK Reconstituted Complex physical 8246987 GSN Affinity Capture-Western physical 11577104 YWHAH Affinity Capture-Western physical 11969417 IRS4 Affinity Capture-MS physical 11912194 HRAS Reconstituted Complex physical 8665852 SGK1 Reconstituted Complex physical 10357815 UBTF Affinity Capture-Western physical 17332342 NEDD9 Two-hybrid physical 18624398 SQSTM1 Two-hybrid physical 18624398 AMBP Two-hybrid physical 18624398 ATPIF1 Two-hybrid physical 18624398 VARS2 Two-hybrid physical 18624398 DDX5 Two-hybrid physical 18624398 DNAJB6 Two-hybrid physical 18624398 FTL Two-hybrid physical 18624398 ITIH1 Two-hybrid physical 18624398 RPS20 Two-hybrid physical 18624398 UFD1L Two-hybrid physical 18624398