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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PIK3R1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001878 response to yeast IEA GO:0001934 positive regulation of protein phosphorylation IEA GO:0006006 glucose metabolic process IEA GO:0007165 signal transduction IEA GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007584 response to nutrient IEA GO:0007596 blood coagulation TAS GO:0008286 insulin receptor signaling pathway IEA GO:0008286 insulin receptor signaling pathway IPI GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0009750 response to fructose stimulus IEA GO:0010040 response to iron(II) ion IEA GO:0010459 negative regulation of heart rate IEA GO:0010628 positive regulation of gene expression IEA GO:0014065 phosphatidylinositol 3-kinase cascade IDA GO:0022408 negative regulation of cell-cell adhesion IEA GO:0030168 platelet activation TAS GO:0030335 positive regulation of cell migration IEA GO:0031295 T cell costimulation TAS GO:0032355 response to estradiol stimulus IEA GO:0032570 response to progesterone stimulus IEA GO:0033574 response to testosterone stimulus IEA GO:0042493 response to drug IEA GO:0043200 response to amino acid stimulus IEA GO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA GO:0044419 interspecies interaction between organisms IEA GO:0045471 response to ethanol IEA GO:0045663 positive regulation of myoblast differentiation IEA GO:0045768 positive regulation of anti-apoptosis IEA GO:0045776 negative regulation of blood pressure IEA GO:0045861 negative regulation of proteolysis IEA GO:0046326 positive regulation of glucose import ISS GO:0046854 phosphatidylinositol phosphorylation ISS GO:0048009 insulin-like growth factor receptor signaling pathway IDA GO:0048009 insulin-like growth factor receptor signaling pathway IEA GO:0048009 insulin-like growth factor receptor signaling pathway IPI GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS GO:0051591 response to cAMP IEA GO:0060396 growth hormone receptor signaling pathway IDA GO:0070848 response to growth factor stimulus IEA GO:0071398 cellular response to fatty acid IEA GO:0071548 response to dexamethasone stimulus IEA GO:0090004 positive regulation of establishment of protein localization in plasma membrane ISS cellular_component GO:0005622 intracellular IEA GO:0005625 soluble fraction IEA GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IEA GO:0005942 phosphatidylinositol 3-kinase complex IEA GO:0005943 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex ISS GO:0019717 synaptosome IEA molecular_function GO:0005158 insulin receptor binding IPI GO:0005159 insulin-like growth factor receptor binding IPI GO:0005515 protein binding IPI GO:0005516 calmodulin binding IEA GO:0005545 1-phosphatidylinositol binding NAS GO:0008022 protein C-terminus binding IEA GO:0019901 protein kinase binding IEA GO:0019903 protein phosphatase binding IPI GO:0019904 protein domain specific binding IEA GO:0030331 estrogen receptor binding IEA GO:0030971 receptor tyrosine kinase binding IEA GO:0031625 ubiquitin protein ligase binding IEA GO:0035014 phosphatidylinositol 3-kinase regulator activity IEA GO:0035014 phosphatidylinositol 3-kinase regulator activity ISS GO:0043125 ErbB-3 class receptor binding IDA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043559 insulin binding IDA GO:0043560 insulin receptor substrate binding IEA GO:0043560 insulin receptor substrate binding ISS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IEA GO:0051117 ATPase binding IEA GO:0051219 phosphoprotein binding IEA

Protein-protein interaction details for PIK3R1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID LCP2 Two-hybrid physical 15388330 LCP2 Affinity Capture-Western physical 15388330 CTNNB1 Reconstituted Complex physical 10477752 SRC Affinity Capture-Western physical 10487518 PXN Co-purification physical 8641358 TLN1 Co-purification physical 8641358 ABL1 Reconstituted Complex physical 8294442 FYN Reconstituted Complex physical 8294442 LCK Reconstituted Complex physical 8294442 PIK3R1 Reconstituted Complex physical 8294442 SHC1 Reconstituted Complex physical 7537361 GNAQ Affinity Capture-Western physical 12704201 WAS Affinity Capture-Western physical 8805332 WAS Reconstituted Complex physical 8805332 IRS2 Affinity Capture-Western physical 8910607 FCGR2A Affinity Capture-Western physical 8631888 VAV1 Affinity Capture-Western physical 9891995 VAV1 Affinity Capture-Western physical 9891995 VAV1 Reconstituted Complex physical 9891995 GAB1 Reconstituted Complex physical 9891995 IRS1 Affinity Capture-Western physical 1381348 PIK3CA Reconstituted Complex physical 7929193 RRAS2 Affinity Capture-Western physical 11850823 KIT Two-hybrid physical 10022833 AXL Biochemical Activity physical 9178760 DOK1 Reconstituted Complex physical 11071635 KIT Reconstituted Complex physical 11071635 EPOR Affinity Capture-Western physical 9162069 EPOR Affinity Capture-Western physical 9162069 VAV1 Affinity Capture-Western physical 9162069 VAV1 Affinity Capture-Western physical 9162069 VAV1 Reconstituted Complex physical 9162069 KHDRBS1 Affinity Capture-Western physical 11604231 CBLB Affinity Capture-Western physical 9614102 IL1R1 Affinity Capture-Western physical 9360994 IL1R1 Affinity Capture-Western physical 9360994 IRS1 Affinity Capture-Western physical 12173038 JAK2 Affinity Capture-Western physical 8702385 JAK2 Affinity Capture-Western physical 8702385 EZR Affinity Capture-Western physical 10377409 EZR Reconstituted Complex physical 10377409 BCAR1 Affinity Capture-Western physical 10799562 BCAR1 Reconstituted Complex physical 10799562 CD28 Protein-peptide physical 8621607 CD28 Affinity Capture-Western physical 8621607 LAT Affinity Capture-Western physical 11368773 LAT Reconstituted Complex physical 11368773 PIK3CD Reconstituted Complex physical 9113989 PIK3CD Affinity Capture-Western physical 9113989 GRB2 Affinity Capture-Western physical 7737969 GRB2 Reconstituted Complex physical 7737969 ERBB3 Affinity Capture-Western physical 11546794 KHDRBS1 Reconstituted Complex physical 10467411 KHDRBS1 Affinity Capture-Western physical 10467411 IRS2 Affinity Capture-Western physical 9334184 IRS2 Affinity Capture-Western physical 9852124 GRB2 Two-hybrid physical 7759531 GRB2 Affinity Capture-Western physical 7759531 GRB2 Reconstituted Complex physical 7759531 PTPN6 Two-hybrid physical 11160222 CD3E Affinity Capture-Western physical 9312149 IRS1 Affinity Capture-Western physical 12730242 EPHA2 Reconstituted Complex physical 7982920 EPHA2 Affinity Capture-Western physical 7982920 EPHA2 Two-hybrid physical 7982920 FCGR2A Reconstituted Complex physical 9268059 ARHGAP17 Reconstituted Complex physical 11431473 ARAF Reconstituted Complex physical 11812000 KIT Affinity Capture-Western physical 7509796 EPOR Affinity Capture-Western physical 7559499 EPOR Reconstituted Complex physical 7559499 CSF1R Affinity Capture-Western physical 8947469 IFNAR1 Affinity Capture-Western physical 10542297 TYRO3 Two-hybrid physical 10627473 TYRO3 Affinity Capture-Western physical 10627473 ARHGAP32 Affinity Capture-Western physical 12454018 CSF2RA Affinity Capture-Western physical 12538575 NFKBIA Reconstituted Complex physical 9892650 GAB2 Affinity Capture-Western physical 11782427 TUBA1B Affinity Capture-Western physical 7592789 TUBA1B Reconstituted Complex physical 7592789 TGFBR1 Affinity Capture-Western physical 9435577 TGFBR2 Affinity Capture-Western physical 9435577 HRAS Affinity Capture-Western physical 10212255 PTK2 Affinity Capture-Western physical 7537275 PTK2 Far Western physical 7537275 ERBB3 Affinity Capture-Western physical 10383151 IRS2 Far Western physical 12107746 IRS1 Far Western physical 12107746 AGAP2 Reconstituted Complex physical 11136977 AGAP2 Affinity Capture-Western physical 11136977 PECAM1 Affinity Capture-Western physical 9774384 CBL Affinity Capture-Western physical 9461587 CBL Affinity Capture-Western physical 9461587 CRKL Affinity Capture-Western physical 9461587 CD7 Reconstituted Complex physical 8918688 ARHGAP1 Reconstituted Complex physical 8253717 FES Affinity Capture-Western physical 8916957 SH3KBP1 Reconstituted Complex physical 10921882 PTPN11 Affinity Capture-Western physical 9918857 INPP5D Affinity Capture-Western physical 9918857 CBL Affinity Capture-Western physical 9918857 PIK3CB Affinity Capture-Western physical 8139559 ADAM12 Reconstituted Complex physical 11313349 ADAM12 Affinity Capture-Western physical 11313349 ADAM12 Affinity Capture-Western physical 11313349 HRAS Reconstituted Complex physical 9150145 GAB1 Affinity Capture-Western physical 8596638 GAB1 Far Western physical 8596638 GHR Reconstituted Complex physical 9632636 CD7 Affinity Capture-Western physical 12594831 IL6ST Affinity Capture-Western physical 10579793 HCST Protein-peptide physical 10426994 ESR1 Affinity Capture-Western physical 11689445 SHB Reconstituted Complex physical 7537362 SHB Affinity Capture-Western physical 7537362 GAB2 Affinity Capture-Western physical 11334882 GAB2 Two-hybrid physical 11334882 NTRK2 Two-hybrid physical 12074588 SYN1 Affinity Capture-Western physical 10899172 PDGFRB Affinity Capture-Western physical 10697503 LTK Affinity Capture-Western physical 8084603 LTK Affinity Capture-Western physical 9223670 CBLB Affinity Capture-Western physical 10022120 CBLB Affinity Capture-Western physical 10022120 GAB1 Two-hybrid physical 9658397 FGFR2 Affinity Capture-Western physical 18374639 CBL Affinity Capture-Western physical 18374639 UBC Affinity Capture-Western physical 18374639 GAB2 Affinity Capture-Western physical 10871282 NPM1 Affinity Capture-MS physical 14968112 GRB2 Two-hybrid physical 20936779 CBL Affinity Capture-MS physical 15107835 SOCS6 Affinity Capture-MS physical 12052866 EPOR PCA physical 15644415 CBL Affinity Capture-Western physical 11994282 UBC Affinity Capture-Western physical 11087752 CBL Affinity Capture-Western physical 11087752 CBL Affinity Capture-Western physical 21203488 PXK Affinity Capture-Western physical 20086096 YWHAG Affinity Capture-MS physical 15324660 EGFR Affinity Capture-MS physical 19531499 ADAMTS2 Two-hybrid physical 18624398 CXCL2 Two-hybrid physical 18624398 CYP4A11 Two-hybrid physical 18624398 TTR Two-hybrid physical 18624398 SH3KBP1 Affinity Capture-Western physical 20457601