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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for POLA1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000076 DNA replication checkpoint IBA GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle TAS GO:0000084 S phase of mitotic cell cycle IDA GO:0000084 S phase of mitotic cell cycle TAS GO:0000216 M/G1 transition of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0000722 telomere maintenance via recombination TAS GO:0000723 telomere maintenance TAS GO:0000731 DNA synthesis involved in DNA repair IMP GO:0006139 nucleobase-containing compound metabolic process IEA GO:0006260 DNA replication IEA GO:0006260 DNA replication IMP GO:0006269 DNA replication, synthesis of RNA primer IBA GO:0006270 DNA-dependent DNA replication initiation IDA GO:0006270 DNA-dependent DNA replication initiation TAS GO:0006271 DNA strand elongation involved in DNA replication IMP GO:0006271 DNA strand elongation involved in DNA replication TAS GO:0006272 leading strand elongation IDA GO:0006273 lagging strand elongation IDA GO:0006281 DNA repair IDA GO:0006303 double-strand break repair via nonhomologous end joining IMP GO:0008283 cell proliferation IDA GO:0032201 telomere maintenance via semi-conservative replication TAS GO:0044419 interspecies interaction between organisms IEA cellular_component GO:0000785 chromatin IDA GO:0005634 nucleus IDA GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005658 alpha DNA polymerase:primase complex IDA GO:0005658 alpha DNA polymerase:primase complex TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0016363 nuclear matrix IDA GO:0043231 intracellular membrane-bounded organelle IDA molecular_function GO:0000166 nucleotide binding IDA GO:0000166 nucleotide binding IEA GO:0001882 nucleoside binding IEA GO:0003677 DNA binding IDA GO:0003677 DNA binding IEA GO:0003677 DNA binding NAS GO:0003682 chromatin binding IDA GO:0003690 double-stranded DNA binding IEA GO:0003887 DNA-directed DNA polymerase activity IDA GO:0003887 DNA-directed DNA polymerase activity IEA GO:0003887 DNA-directed DNA polymerase activity IMP GO:0003896 DNA primase activity IDA GO:0005515 protein binding IPI GO:0016740 transferase activity IEA GO:0016779 nucleotidyltransferase activity IEA GO:0017076 purine nucleotide binding IEA GO:0019103 pyrimidine nucleotide binding IEA GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IEA

Protein-protein interaction details for POLA1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RBMS1 Two-hybrid physical 10869558 CDK2AP1 Reconstituted Complex physical 10877824 CDK2 Biochemical Activity physical 10877824 CDC45 Reconstituted Complex physical 10518787 RB1 Affinity Capture-Western physical 9395244 RB1 Co-purification physical 9395244 RBMS1 Affinity Capture-Western physical 10869558 RBMS1 Reconstituted Complex physical 10869558 RBMS1 Phenotypic Enhancement genetic 10869558 XRCC5 Affinity Capture-Western physical 12393188 POLA2 Reconstituted Complex physical 8223465 PARP1 Affinity Capture-Western physical 9518481 PARP1 Far Western physical 9518481 HELB Reconstituted Complex physical 12181327 TP53 Affinity Capture-Western physical 11917009 RAE1 Affinity Capture-MS physical 19615732 CHEK1 Affinity Capture-Western physical 19177015