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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PROX1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0001709 cell fate determination IEA GO:0001822 kidney development IEP GO:0001889 liver development IEP GO:0001938 positive regulation of endothelial cell proliferation IDA GO:0001945 lymph vessel development IEA GO:0001946 lymphangiogenesis IDA GO:0002088 lens development in camera-type eye IEP GO:0006351 transcription, DNA-dependent IC GO:0006355 regulation of transcription, DNA-dependent IC GO:0006355 regulation of transcription, DNA-dependent IEA GO:0007275 multicellular organismal development IEA GO:0007420 brain development IEP GO:0008284 positive regulation of cell proliferation IDA GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation IMP GO:0010468 regulation of gene expression IDA GO:0010595 positive regulation of endothelial cell migration IDA GO:0021516 dorsal spinal cord development ISS GO:0021915 neural tube development ISS GO:0030240 skeletal muscle thin filament assembly IEA GO:0030240 skeletal muscle thin filament assembly ISS GO:0030324 lung development IEP GO:0030910 olfactory placode formation ISS GO:0031016 pancreas development IEP GO:0043049 otic placode formation ISS GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0045071 negative regulation of viral genome replication IDA GO:0045446 endothelial cell differentiation IEA GO:0045737 positive regulation of cyclin-dependent protein kinase activity IDA GO:0045750 positive regulation of S phase of mitotic cell cycle IDA GO:0045787 positive regulation of cell cycle IEA GO:0045787 positive regulation of cell cycle ISS GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046619 optic placode formation involved in camera-type eye formation IEA GO:0046619 optic placode formation involved in camera-type eye formation ISS GO:0048845 venous blood vessel morphogenesis IEA GO:0048845 venous blood vessel morphogenesis ISS GO:0055005 ventricular cardiac myofibril development IEA GO:0055005 ventricular cardiac myofibril development ISS GO:0055009 atrial cardiac muscle tissue morphogenesis IEA GO:0055009 atrial cardiac muscle tissue morphogenesis ISS GO:0055010 ventricular cardiac muscle tissue morphogenesis IEA GO:0055010 ventricular cardiac muscle tissue morphogenesis ISS GO:0060042 retina morphogenesis in camera-type eye ISS GO:0060059 embryonic retina morphogenesis in camera-type eye IEA GO:0060059 embryonic retina morphogenesis in camera-type eye IEP GO:0060214 endocardium formation IEA GO:0060214 endocardium formation ISS GO:0060298 positive regulation of sarcomere organization IEA GO:0060298 positive regulation of sarcomere organization ISS GO:0060412 ventricular septum morphogenesis IEA GO:0060412 ventricular septum morphogenesis ISS GO:0060414 aorta smooth muscle tissue morphogenesis IEA GO:0060414 aorta smooth muscle tissue morphogenesis ISS GO:0060421 positive regulation of heart growth IEA GO:0060421 positive regulation of heart growth ISS GO:0060836 lymphatic endothelial cell differentiation IDA GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment IMP GO:0070309 lens fiber cell morphogenesis IEA GO:0070309 lens fiber cell morphogenesis IEP GO:0070365 hepatocyte differentiation IEA GO:0070365 hepatocyte differentiation IEP GO:0070858 negative regulation of bile acid biosynthetic process IMP cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA molecular_function GO:0003677 DNA binding IEA GO:0003677 DNA binding IMP GO:0003700 sequence-specific DNA binding transcription factor activity IC GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IEA GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity ISS GO:0003714 transcription corepressor activity IDA GO:0005515 protein binding IPI GO:0016922 ligand-dependent nuclear receptor binding IPI GO:0044212 transcription regulatory region DNA binding IDA GO:0050692 DBD domain binding IPI GO:0050693 LBD domain binding IPI

Protein-protein interaction details for PROX1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID EP300 Two-hybrid physical 11943779 EP300 Affinity Capture-Western physical 11943779 PAX6 Reconstituted Complex physical 11069920 IRF4 Two-hybrid physical 20211142 ZBTB3 Two-hybrid physical 20211142 HDAC3 Affinity Capture-Western physical 18948102 PPARD Two-hybrid physical 15604093 RORA Two-hybrid physical 15604093 HNF4A Two-hybrid physical 15604093 ESRRA Two-hybrid physical 15604093 ESRRG Two-hybrid physical 15604093 NR3C2 Two-hybrid physical 15604093