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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PSEN1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000045 autophagic vacuole assembly IEA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000186 activation of MAPKK activity IEA GO:0001568 blood vessel development IEA GO:0001708 cell fate specification IEA GO:0001756 somitogenesis IEA GO:0001764 neuron migration IEA GO:0001921 positive regulation of receptor recycling IEA GO:0001933 negative regulation of protein phosphorylation IEA GO:0001934 positive regulation of protein phosphorylation IEA GO:0001947 heart looping IEA GO:0002244 hemopoietic progenitor cell differentiation IEA GO:0002286 T cell activation involved in immune response IEA GO:0002573 myeloid leukocyte differentiation IEA GO:0006469 negative regulation of protein kinase activity IEA GO:0006486 protein glycosylation IEA GO:0006509 membrane protein ectodomain proteolysis IDA GO:0006509 membrane protein ectodomain proteolysis IEA GO:0006816 calcium ion transport IBA GO:0006839 mitochondrial transport IEA GO:0006914 autophagy IEA GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis IDA GO:0006916 anti-apoptosis IEA GO:0006974 response to DNA damage stimulus IEA GO:0006979 response to oxidative stress IEA GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA GO:0007219 Notch signaling pathway IEA GO:0007219 Notch signaling pathway TAS GO:0007220 Notch receptor processing IBA GO:0007220 Notch receptor processing IEA GO:0007220 Notch receptor processing TAS GO:0007507 heart development IEA GO:0007613 memory IEA GO:0008219 cell death IEA GO:0008624 induction of apoptosis by extracellular signals TAS GO:0009790 embryo development IEA GO:0009791 post-embryonic development IEA GO:0015031 protein transport IEA GO:0015813 L-glutamate transport IEA GO:0015871 choline transport IEA GO:0016080 synaptic vesicle targeting IEA GO:0016337 cell-cell adhesion IMP GO:0016485 protein processing IDA GO:0016485 protein processing IEA GO:0021795 cerebral cortex cell migration IEA GO:0021870 Cajal-Retzius cell differentiation IEA GO:0021904 dorsal/ventral neural tube patterning IEA GO:0022008 neurogenesis IEA GO:0030326 embryonic limb morphogenesis IEA GO:0030900 forebrain development IEA GO:0031293 membrane protein intracellular domain proteolysis TAS GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA GO:0032469 endoplasmic reticulum calcium ion homeostasis IDA GO:0032469 endoplasmic reticulum calcium ion homeostasis IGI GO:0035556 intracellular signal transduction IEA GO:0040011 locomotion IEA GO:0042325 regulation of phosphorylation IDA GO:0042640 anagen IEA GO:0042987 amyloid precursor protein catabolic process IBA GO:0042987 amyloid precursor protein catabolic process IEA GO:0042987 amyloid precursor protein catabolic process TAS GO:0043065 positive regulation of apoptosis IEA GO:0043085 positive regulation of catalytic activity IDA GO:0043393 regulation of protein binding IEA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043524 negative regulation of neuron apoptosis IEA GO:0043589 skin morphogenesis IEA GO:0045860 positive regulation of protein kinase activity IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048167 regulation of synaptic plasticity IEA GO:0048538 thymus development IEA GO:0048666 neuron development IEA GO:0048705 skeletal system morphogenesis IEA GO:0048854 brain morphogenesis IEA GO:0050435 beta-amyloid metabolic process IBA GO:0050435 beta-amyloid metabolic process IEA GO:0050673 epithelial cell proliferation IEA GO:0050771 negative regulation of axonogenesis IEA GO:0050820 positive regulation of coagulation IEA GO:0050852 T cell receptor signaling pathway IEA GO:0051444 negative regulation of ubiquitin-protein ligase activity IEA GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IBA GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IEA GO:0051966 regulation of synaptic transmission, glutamatergic IEA GO:0060075 regulation of resting membrane potential IEA GO:0070588 calcium ion transmembrane transport IMP GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA cellular_component GO:0000139 Golgi membrane IEA GO:0000776 kinetochore IDA GO:0005624 membrane fraction TAS GO:0005634 nucleus IEA GO:0005640 nuclear outer membrane IDA GO:0005739 mitochondrion IDA GO:0005739 mitochondrion IEA GO:0005743 mitochondrial inner membrane IBA GO:0005743 mitochondrial inner membrane IEA GO:0005765 lysosomal membrane IBA GO:0005765 lysosomal membrane IEA GO:0005783 endoplasmic reticulum IDA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005790 smooth endoplasmic reticulum IDA GO:0005791 rough endoplasmic reticulum IDA GO:0005794 Golgi apparatus IDA GO:0005794 Golgi apparatus IEA GO:0005813 centrosome IDA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane IDA GO:0005938 cell cortex IBA GO:0009986 cell surface IBA GO:0009986 cell surface IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0016021 integral to membrane TAS GO:0016324 apical plasma membrane IBA GO:0019717 synaptosome IEA GO:0030018 Z disc IBA GO:0030424 axon IBA GO:0030424 axon IEA GO:0030426 growth cone IBA GO:0030426 growth cone IEA GO:0031410 cytoplasmic vesicle IEA GO:0031594 neuromuscular junction IBA GO:0031594 neuromuscular junction IEA GO:0031965 nuclear membrane IDA GO:0035253 ciliary rootlet IBA GO:0035253 ciliary rootlet IEA GO:0043025 neuronal cell body IBA GO:0043025 neuronal cell body IEA GO:0043198 dendritic shaft IBA GO:0043198 dendritic shaft IEA GO:0043227 membrane-bounded organelle IEA GO:0043234 protein complex IEA GO:0045121 membrane raft IBA GO:0045121 membrane raft IEA GO:0048471 perinuclear region of cytoplasm IBA GO:0070765 gamma-secretase complex IDA molecular_function GO:0004175 endopeptidase activity IDA GO:0004175 endopeptidase activity TAS GO:0004190 aspartic-type endopeptidase activity IEA GO:0004190 aspartic-type endopeptidase activity TAS GO:0005262 calcium channel activity IMP GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IPI GO:0008233 peptidase activity IEA GO:0008233 peptidase activity TAS GO:0030165 PDZ domain binding IPI GO:0045296 cadherin binding IBA GO:0045296 cadherin binding IEA

Protein-protein interaction details for PSEN1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CTNNB1 Affinity Capture-Western physical 9852041 CTNNB1 Affinity Capture-Western physical 10341227 NCSTN Affinity Capture-Western physical 15257293 CLSTN1 Affinity Capture-Western physical 15037614 NCSTN Affinity Capture-Western physical 14572442 PSENEN Affinity Capture-Western physical 14572442 APH1A Affinity Capture-Western physical 14572442 NCSTN Affinity Capture-Western physical 14572442 PSENEN Affinity Capture-Western physical 14572442 APH1A Affinity Capture-Western physical 14572442 PSENEN Affinity Capture-Western physical 12639958 GFAP Two-hybrid physical 12058025 GFAP Reconstituted Complex physical 12058025 FLNB Two-hybrid physical 9437013 FLNB Reconstituted Complex physical 9437013 ICAM5 Affinity Capture-Western physical 11719200 ICAM5 Two-hybrid physical 11719200 ICAM5 Reconstituted Complex physical 11719200 PKP4 Affinity Capture-Western physical 10092585 PKP4 Reconstituted Complex physical 10092585 PKP4 Two-hybrid physical 10092585 KCNIP3 Affinity Capture-Western physical 9771752 FBXW7 Affinity Capture-Western physical 12354302 APH1A Co-fractionation physical 12471034 APH1A Affinity Capture-Western physical 12471034 PSEN2 Affinity Capture-Western physical 12471034 NCSTN Affinity Capture-Western physical 12471034 APH1A Affinity Capture-Western physical 12471034 NCSTN Affinity Capture-Western physical 12471034 BCL2 Two-hybrid physical 10521466 BCL2 Affinity Capture-Western physical 10521466 APH1A Affinity Capture-Western physical 12297508 NCSTN Affinity Capture-Western physical 12297508 UBQLN1 Two-hybrid physical 11076969 UBQLN1 Reconstituted Complex physical 11076969 CDH1 Affinity Capture-Western physical 10635315 CTNNA1 Affinity Capture-Western physical 10635315 NCSTN Affinity Capture-Western physical 10993067 PSENEN Affinity Capture-Western physical 12198112 NOTCH1 Affinity Capture-Western physical 10077672 TCF7L2 Affinity Capture-Western physical 11504726 KCNIP3 Affinity Capture-Western physical 10854253 BCL2L1 Two-hybrid physical 10446169 HERPUD1 Affinity Capture-Western physical 11799129 CTNNB1 Affinity Capture-Western physical 9738936 ERN1 Affinity Capture-Western physical 10587643 CTNND1 Two-hybrid physical 10208590 CTNND1 Reconstituted Complex physical 10208590 CTNND1 Affinity Capture-Western physical 10208590 MAPT Co-fractionation physical 9689133 KCNIP4 Two-hybrid physical 11847232 CIB1 Two-hybrid physical 10366599 TRAF6 Affinity Capture-Western physical 19012753 PSEN1 Two-hybrid physical 12535650 YME1L1 Two-hybrid physical 12214059 GSK3B Biochemical Activity physical 17360711 CTNNB1 Reconstituted Complex physical 17360711 CTNNB1 Affinity Capture-Western physical 17360711 CTNNB1 Affinity Capture-Western physical 17360711 CDH1 Affinity Capture-Western physical 16126725 CTNNB1 Affinity Capture-Western physical 16126725