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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SMYD2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0006355 regulation of transcription, DNA-dependent IEA GO:0008285 negative regulation of cell proliferation ISS GO:0010452 histone H3-K36 methylation ISS GO:0016568 chromatin modification IEA GO:0018026 peptidyl-lysine monomethylation IDA GO:0018027 peptidyl-lysine dimethylation ISS GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IMP cellular_component GO:0005634 nucleus ISS GO:0005737 cytoplasm ISS GO:0005829 cytosol ISS molecular_function GO:0000993 RNA polymerase II core binding ISS GO:0002039 p53 binding IPI GO:0005515 protein binding IPI GO:0008168 methyltransferase activity IEA GO:0008270 zinc ion binding IEA GO:0016279 protein-lysine N-methyltransferase activity IDA GO:0016740 transferase activity IEA GO:0046872 metal ion binding IEA GO:0046975 histone methyltransferase activity (H3-K36 specific) ISS

Protein-protein interaction details for SMYD2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID GSK3B Affinity Capture-MS physical 17353931 GSK3B Affinity Capture-MS physical 17353931 EPB41L3 Affinity Capture-MS physical 17353931 CLASP2 Affinity Capture-MS physical 17353931 AKAP11 Affinity Capture-MS physical 17353931 CDC37 Affinity Capture-MS physical 17353931 IGF2BP1 Affinity Capture-MS physical 17353931 AXIN1 Affinity Capture-MS physical 17353931 TP53 Biochemical Activity physical 17108971 TP53 Affinity Capture-Western physical 17108971 TP53 Affinity Capture-Western physical 18065756 EPB41L3 Affinity Capture-Western physical 18065756 HSP90AA1 Affinity Capture-Western physical 18065756 RB1 Biochemical Activity physical 20870719 RB1 Reconstituted Complex physical 20870719 RB1 Affinity Capture-Western physical 20870719