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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PTGS2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001516 prostaglandin biosynthetic process NAS GO:0006633 fatty acid biosynthetic process IEA GO:0006692 prostanoid metabolic process TAS GO:0006693 prostaglandin metabolic process TAS GO:0006805 xenobiotic metabolic process TAS GO:0006928 cellular component movement TAS GO:0006979 response to oxidative stress IEA GO:0007566 embryo implantation IEA GO:0007613 memory IEA GO:0008217 regulation of blood pressure ISS GO:0008285 negative regulation of cell proliferation IEA GO:0009750 response to fructose stimulus IEA GO:0010042 response to manganese ion IEA GO:0010243 response to organic nitrogen IEA GO:0010575 positive regulation vascular endothelial growth factor production ISS GO:0014070 response to organic cyclic compound IEA GO:0019371 cyclooxygenase pathway IDA GO:0030282 bone mineralization IEA GO:0030728 ovulation IEA GO:0031394 positive regulation of prostaglandin biosynthetic process NAS GO:0031622 positive regulation of fever generation ISS GO:0031915 positive regulation of synaptic plasticity IEA GO:0032227 negative regulation of synaptic transmission, dopaminergic IEA GO:0032355 response to estradiol stimulus IEA GO:0032496 response to lipopolysaccharide IEA GO:0033280 response to vitamin D IEA GO:0034097 response to cytokine stimulus IEA GO:0042493 response to drug IEA GO:0042640 anagen IEA GO:0043065 positive regulation of apoptosis IEA GO:0045429 positive regulation of nitric oxide biosynthetic process ISS GO:0045907 positive regulation of vasoconstriction IEA GO:0045987 positive regulation of smooth muscle contraction IEA GO:0046697 decidualization IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050727 regulation of inflammatory response NAS GO:0051384 response to glucocorticoid stimulus IEA GO:0051726 regulation of cell cycle IEA GO:0051926 negative regulation of calcium ion transport IEA GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA GO:0071636 positive regulation of transforming growth factor beta production ISS GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS GO:0090271 positive regulation of fibroblast growth factor production ISS GO:0090336 positive regulation of brown fat cell differentiation ISS GO:0090362 positive regulation of platelet-derived growth factor production ISS cellular_component GO:0005634 nucleus ISS GO:0005737 cytoplasm IDA GO:0005737 cytoplasm ISS GO:0005783 endoplasmic reticulum IEA GO:0005788 endoplasmic reticulum lumen TAS GO:0005789 endoplasmic reticulum membrane IEA GO:0005792 microsome IEA GO:0005901 caveola IEA GO:0016020 membrane IEA GO:0043005 neuron projection IDA GO:0043234 protein complex IEA molecular_function GO:0004601 peroxidase activity NAS GO:0004601 peroxidase activity TAS GO:0004666 prostaglandin-endoperoxide synthase activity IDA GO:0008289 lipid binding IEA GO:0016491 oxidoreductase activity IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA GO:0019899 enzyme binding IPI GO:0020037 heme binding IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for PTGS2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TP53 Affinity Capture-Western physical 11687965 NUCB1 Two-hybrid physical 8643612 CAV1 Affinity Capture-Western physical 11432874 CAV1 Affinity Capture-Western physical 11432874 CAV1 Reconstituted Complex physical 11432874 COPS5 Co-fractionation physical 17429597 COPS7A Affinity Capture-Western physical 17429597 COPS5 Affinity Capture-Western physical 17429597 COPS3 Affinity Capture-Western physical 17429597 CUL1 Affinity Capture-Western physical 17429597 CUL4A Affinity Capture-Western physical 17429597 RBX1 Affinity Capture-Western physical 17429597 PSMD1 Affinity Capture-Western physical 17429597 PSMC5 Affinity Capture-Western physical 17429597 UBC Affinity Capture-Western physical 19960513 CAV1 Affinity Capture-Western physical 19960513