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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PTK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000226 microtubule cytoskeleton organization IEA GO:0001525 angiogenesis IEA GO:0001568 blood vessel development IEA GO:0001570 vasculogenesis IEA GO:0001764 neuron migration IEA GO:0006468 protein phosphorylation IEA GO:0006468 protein phosphorylation TAS GO:0006915 apoptosis TAS GO:0006921 cellular component disassembly involved in apoptosis TAS GO:0007172 signal complex assembly IEA GO:0007229 integrin-mediated signaling pathway TAS GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0018108 peptidyl-tyrosine phosphorylation IDA GO:0021955 central nervous system neuron axonogenesis IEA GO:0030198 extracellular matrix organization IEA GO:0033628 regulation of cell adhesion mediated by integrin IDA GO:0040023 establishment of nucleus localization IEA GO:0043542 endothelial cell migration IEA GO:0046621 negative regulation of organ growth IEA GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation IEA GO:0048013 ephrin receptor signaling pathway IDA GO:0050771 negative regulation of axonogenesis IEA GO:0051964 negative regulation of synapse assembly IEA GO:0060396 growth hormone receptor signaling pathway IDA cellular_component GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane IEA GO:0005925 focal adhesion IDA GO:0005925 focal adhesion IEA GO:0016324 apical plasma membrane IEA GO:0030027 lamellipodium IEA GO:0030054 cell junction IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004672 protein kinase activity TAS GO:0004713 protein tyrosine kinase activity IEA GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA GO:0004871 signal transducer activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008432 JUN kinase binding IDA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0019901 protein kinase binding IPI GO:0042169 SH2 domain binding IPI

Protein-protein interaction details for PTK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IRS1 Two-hybrid physical 9822703 SOCS2 Two-hybrid physical 16189514 ATG12 Two-hybrid physical 16189514 TRIP6 Affinity Capture-Western physical 14688263 BCAR1 Affinity Capture-Western physical 8810278 CIB1 Affinity Capture-Western physical 12881299 GIT1 Affinity Capture-Western physical 12629171 BCAR1 Affinity Capture-Western physical 12615911 DOCK1 Affinity Capture-Western physical 12615911 SRC Affinity Capture-Western physical 12615911 CRK Affinity Capture-Western physical 12615911 PXN Affinity Capture-Western physical 11514617 ITGB5 Reconstituted Complex physical 11927607 ITGB3 Reconstituted Complex physical 11927607 ITGB5 Affinity Capture-Western physical 11927607 MAPK8IP3 Affinity Capture-Western physical 12226752 MAPK8IP3 Affinity Capture-Western physical 12226752 GIT1 Affinity Capture-Western physical 12473661 EGFR Affinity Capture-Western physical 10806474 GRB2 Affinity Capture-Western physical 10806474 JAK2 Affinity Capture-Western physical 9553131 SRC Affinity Capture-Western physical 11980671 SHC1 Affinity Capture-Western physical 11980671 EZR Reconstituted Complex physical 11468295 PTEN Affinity Capture-Western physical 10400703 STAT1 Affinity Capture-Western physical 11278462 STAT1 Affinity Capture-Western physical 11278462 STAT1 Reconstituted Complex physical 11278462 TGFB1I1 Reconstituted Complex physical 9422762 PXN Reconstituted Complex physical 9422762 TGFB1I1 Affinity Capture-Western physical 11463817 CCR5 Affinity Capture-Western physical 10384144 GSK3B Affinity Capture-Western physical 11809746 CXCR4 Affinity Capture-Western physical 11668182 TGFB1I1 Reconstituted Complex physical 9858471 BMX Affinity Capture-Western physical 11331870 BMX Reconstituted Complex physical 11331870 PCSK1 Affinity Capture-Western physical 11113628 GIT1 Affinity Capture-Western physical 10938112 GIT1 Reconstituted Complex physical 10938112 TSC2 Affinity Capture-Western physical 17043358 TSC2 Reconstituted Complex physical 17043358 TSC1 Affinity Capture-Western physical 17043358 TSC2 Affinity Capture-Western physical 17043358 TSC2 Reconstituted Complex physical 17043358 PLCG1 Affinity Capture-Western physical 10430888 PXN Reconstituted Complex physical 10330411 IGF1R Affinity Capture-Western physical 10082579 PTPN11 Affinity Capture-Western physical 10082579 CRK Reconstituted Complex physical 10085298 GRB2 Reconstituted Complex physical 10085298 SRC Reconstituted Complex physical 10085298 EPHA2 Affinity Capture-Western physical 10655584 ARHGAP26 Reconstituted Complex physical 8649427 BCAR1 Reconstituted Complex physical 8649427 GRB2 Reconstituted Complex physical 8649427 PXN Affinity Capture-Western physical 11919182 ITGA4 Affinity Capture-Western physical 11919182 PXN Reconstituted Complex physical 11919182 PXN Reconstituted Complex physical 9054445 NCK1 Reconstituted Complex physical 8879209 SRC Affinity Capture-Western physical 12387730 FGR Affinity Capture-Western physical 12387730 TLN1 Affinity Capture-Western physical 7622520 TLN1 Reconstituted Complex physical 7622520 GSN Affinity Capture-Western physical 11577104 BCAR1 Affinity Capture-Western physical 11577104 TLN1 Affinity Capture-Western physical 9442086 PXN Affinity Capture-Western physical 9442086 PXN Reconstituted Complex physical 8922390 SRC Affinity Capture-Western physical 12558988 GRB2 Affinity Capture-Western physical 12558988 AMPH Affinity Capture-Western physical 12558988 BIN1 Affinity Capture-Western physical 12558988 FYN Affinity Capture-Western physical 12558988 YES1 Affinity Capture-Western physical 12558988 NEDD9 Affinity Capture-Western physical 8668148 NEDD9 Two-hybrid physical 8668148 JAK2 Affinity Capture-Western physical 10925297 STAT3 Affinity Capture-Western physical 10925297 PPP1CB Affinity Capture-Western physical 11513739 PTK2 Co-crystal Structure physical 12005431 GRB2 Reconstituted Complex physical 12005431 SYK Affinity Capture-Western physical 9169439 LYN Affinity Capture-Western physical 9169439 ITGB3 Affinity Capture-Western physical 9169439 PIK3R1 Affinity Capture-Western physical 7537275 PIK3R1 Far Western physical 7537275 SYK Affinity Capture-Western physical 9342235 PXN Affinity Capture-Western physical 9756887 SELE Affinity Capture-Western physical 8609175 RB1CC1 Reconstituted Complex physical 10769033 RB1CC1 Affinity Capture-Western physical 10769033 NCK1 Affinity Capture-Western physical 11950595 NCK1 Reconstituted Complex physical 11950595 NCK2 Reconstituted Complex physical 11950595 NCK2 Affinity Capture-Western physical 11950595 GRB7 Reconstituted Complex physical 10446223 GRB7 Affinity Capture-Western physical 10446223 PXN Affinity Capture-Western physical 10455189 CSK Affinity Capture-Western physical 7529872 PTEN Affinity Capture-Western physical 11857088 FYN Co-crystal Structure physical 11278857 BCAR1 Affinity Capture-Western physical 12135674 BCAR1 Affinity Capture-Western physical 10753828 PXN Affinity Capture-Western physical 10753828 SRC Two-hybrid physical 9822703 IRS1 Affinity Capture-Western physical 9822703 DCC Reconstituted Complex physical 15494733 DCC Affinity Capture-Western physical 15494733 NEO1 Affinity Capture-Western physical 15494733 NEO1 Two-hybrid physical 15494733 DCC Two-hybrid physical 15494733 GAPDH Co-fractionation physical 18206965 PARP1 Co-fractionation physical 18206965 TP53 Affinity Capture-Western physical 18206965 TP53 Reconstituted Complex physical 18206965 MDM2 Reconstituted Complex physical 18206965 NEDD8 Affinity Capture-MS physical 16620772 RAC1 Two-hybrid physical 20936779 DCC Affinity Capture-Western physical 20434207 DCC Affinity Capture-MS physical 20434207 PTEN Affinity Capture-Western physical 15717329 UBC Affinity Capture-Western physical 18031698 SOCS3 Affinity Capture-Western physical 18031698 SOCS3 Affinity Capture-Western physical 18031698 HES1 Two-hybrid physical 21900206 NASP Two-hybrid physical 21900206 FBP1 Two-hybrid physical 21900206 F13A1 Two-hybrid physical 21900206 BBS10 Two-hybrid physical 21900206 NACAD Two-hybrid physical 21900206 EEF1G Two-hybrid physical 21900206 DDX39 Two-hybrid physical 21900206 ZNF331 Two-hybrid physical 21900206 TGFB1I1 Two-hybrid physical 21900206 EPS8L2 Two-hybrid physical 21900206 LPXN Two-hybrid physical 21900206 GRB2 Two-hybrid physical 21900206 UBC Affinity Capture-Western physical 22203672 CBL Co-localization physical 22203672