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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CHD8 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001701 in utero embryonic development IEA GO:0016568 chromatin modification IEA GO:0030178 negative regulation of Wnt receptor signaling pathway IDA GO:0043044 ATP-dependent chromatin remodeling IMP GO:0043066 negative regulation of apoptosis IEA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0045945 positive regulation of transcription from RNA polymerase III promoter IMP GO:0060070 canonical Wnt receptor signaling pathway IDA cellular_component GO:0005634 nucleus IDA GO:0043234 protein complex IDA GO:0071339 MLL1 complex IDA molecular_function GO:0000166 nucleotide binding IEA GO:0002039 p53 binding ISS GO:0003677 DNA binding IMP GO:0003678 DNA helicase activity IMP GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0008013 beta-catenin binding IDA GO:0008094 DNA-dependent ATPase activity IDA GO:0016817 hydrolase activity, acting on acid anhydrides IEA GO:0035064 methylated histone residue binding IDA GO:0042393 histone binding ISS GO:0070016 armadillo repeat domain binding IEA

Protein-protein interaction details for CHD8 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TOP3B Two-hybrid physical 11549288 TCERG1 Affinity Capture-MS physical 15456888 CTCF Reconstituted Complex physical 16949368 CTCF Affinity Capture-Western physical 16949368 CTCF Two-hybrid physical 16949368 ZNF143 Affinity Capture-Western physical 17938208 CTDP1 Affinity Capture-Western physical 19255092 WDR5 Reconstituted Complex physical 18378692 WDR5 Affinity Capture-Western physical 18378692 CTNNB1 Affinity Capture-Western physical 18378692 CTNNB1 Reconstituted Complex physical 18378692 TP53 Affinity Capture-Western physical 19151705 CASR Affinity Capture-Western physical 19151705 ASH2L Co-localization physical 20085832 WDR5 Reconstituted Complex physical 20085832 ASH2L Reconstituted Complex physical 20085832 RBBP5 Reconstituted Complex physical 20085832 CREB1 Two-hybrid physical 20936779 USF1 Affinity Capture-MS physical 17846119 TERF1 Affinity Capture-MS physical 20811636 TERF2 Affinity Capture-MS physical 20811636