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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for RAF1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade TAS GO:0000186 activation of MAPKK activity TAS GO:0001666 response to hypoxia IEA GO:0006468 protein phosphorylation TAS GO:0006915 apoptosis TAS GO:0007010 cytoskeleton organization IEA GO:0007165 signal transduction TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007264 small GTPase mediated signal transduction TAS GO:0007265 Ras protein signal transduction TAS GO:0007268 synaptic transmission TAS GO:0007411 axon guidance TAS GO:0007507 heart development IEA GO:0007596 blood coagulation TAS GO:0008283 cell proliferation TAS GO:0008285 negative regulation of cell proliferation IDA GO:0008286 insulin receptor signaling pathway TAS GO:0030168 platelet activation TAS GO:0031333 negative regulation of protein complex assembly IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA GO:0035556 intracellular signal transduction IEA GO:0043066 negative regulation of apoptosis IDA GO:0048011 nerve growth factor receptor signaling pathway TAS cellular_component GO:0005626 insoluble fraction IEA GO:0005737 cytoplasm ISS GO:0005741 mitochondrial outer membrane TAS GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004709 MAP kinase kinase kinase activity IEA GO:0005057 receptor signaling protein activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0017016 Ras GTPase binding IEA GO:0031434 mitogen-activated protein kinase kinase binding IEA GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IEA

Protein-protein interaction details for RAF1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID YWHAQ Affinity Capture-MS physical 17353931 YWHAG Affinity Capture-MS physical 17353931 YWHAZ Reconstituted Complex physical 9261098 SFN Affinity Capture-MS physical 15778465 HRAS Two-hybrid physical 9154803 HRAS Two-hybrid physical 14654780 VDAC1 Affinity Capture-Western physical 12079506 PEBP4 Affinity Capture-Western physical 15302887 PEBP4 Reconstituted Complex physical 15302887 CNKSR1 Reconstituted Complex physical 15075335 HRAS Reconstituted Complex physical 15031288 HRAS Reconstituted Complex physical 14724584 RASD2 Reconstituted Complex physical 14724584 CNKSR2 Affinity Capture-Western physical 14597674 CNKSR2 Affinity Capture-Western physical 14597674 ERAS Affinity Capture-Western physical 12774123 SPRY4 Affinity Capture-Western physical 12717443 SPRY2 Affinity Capture-Western physical 12717443 YWHAB Two-hybrid physical 12620389 HRAS Two-hybrid physical 12620389 OIP5 Two-hybrid physical 12620389 PHKA2 Two-hybrid physical 12620389 CCT3 Two-hybrid physical 12620389 MYC Reconstituted Complex physical 9315742 AR Co-purification physical 8349631 MRAS Reconstituted Complex physical 10498616 KRAS Two-hybrid physical 10783161 HRAS Two-hybrid physical 10783161 LRPAP1 Two-hybrid physical 10783161 RRAS2 Two-hybrid physical 10783161 SHOC2 Affinity Capture-Western physical 10783161 SHOC2 Affinity Capture-Western physical 10783161 HRAS Reconstituted Complex physical 10783161 TSC22D3 Affinity Capture-Western physical 12391160 TSC22D3 Reconstituted Complex physical 12391160 MST4 Two-hybrid physical 11306563 MAPK1 Affinity Capture-Western physical 11409918 MAPK3 Affinity Capture-Western physical 11409918 PRKCE Affinity Capture-Western physical 11350735 YWHAZ Affinity Capture-Western physical 10887173 YWHAZ Reconstituted Complex physical 10887173 BCL2 Reconstituted Complex physical 8929532 BCL2L1 Reconstituted Complex physical 8929532 BCL2 Two-hybrid physical 8929532 BCL2 Affinity Capture-Western physical 8929532 YWHAQ Reconstituted Complex physical 10757792 PEBP1 Reconstituted Complex physical 10757792 MAP2K1 Reconstituted Complex physical 10757792 MAP2K1 Reconstituted Complex physical 10757792 PEBP1 Reconstituted Complex physical 10757792 PEBP1 Affinity Capture-Western physical 10757792 RRAS2 Reconstituted Complex physical 10557073 GRB10 Co-fractionation physical 10585452 GRB10 Two-hybrid physical 10585452 GRB10 Affinity Capture-Western physical 10585452 HRAS Affinity Capture-Western physical 10882715 KRAS Affinity Capture-Western physical 10882715 NRAS Affinity Capture-Western physical 10882715 HRAS Two-hybrid physical 9523700 HRAS Two-hybrid physical 10922060 MAPK8IP3 Affinity Capture-Western physical 11044439 MAPK8IP3 Reconstituted Complex physical 11044439 YWHAG Affinity Capture-Western physical 10433554 AKT1 Biochemical Activity physical 10576742 AKT1 Affinity Capture-Western physical 10576742 HSP90AA1 Affinity Capture-Western physical 8408024 GNG4 Reconstituted Complex physical 7782277 GNB2 Affinity Capture-Western physical 7782277 VAV1 Affinity Capture-Western physical 8900182 HRAS Affinity Capture-Western physical 16803888 RHEB Affinity Capture-Western physical 15854902 RHEB Affinity Capture-Western physical 15150271 RHEB Reconstituted Complex physical 15854902 RHEB Affinity Capture-Western physical 15150271 HRAS Two-hybrid physical 7862125 RAP1A Two-hybrid physical 7862125 SRC Affinity Capture-Western physical 7517401 SRC Reconstituted Complex physical 7517401 FYN Affinity Capture-Western physical 7517401 FYN Reconstituted Complex physical 7517401 YWHAZ Reconstituted Complex physical 7628630 YWHAZ Affinity Capture-Western physical 7628630 RB1 Reconstituted Complex physical 9819434 RBL2 Reconstituted Complex physical 9819434 RB1 Two-hybrid physical 9819434 RBL2 Two-hybrid physical 9819434 RB1 Affinity Capture-Western physical 9819434 RBL2 Affinity Capture-Western physical 9819434 PRKG1 Affinity Capture-Western physical 12237340 JAK2 Reconstituted Complex physical 8876196 RHEB Two-hybrid physical 9001246 RHEB Reconstituted Complex physical 9001246 HRAS Reconstituted Complex physical 7969158 RAP1A Co-crystal Structure physical 7791872 YWHAH Affinity Capture-Western physical 11969417 HRAS Two-hybrid physical 10369681 CFLAR Affinity Capture-Western physical 10837247 CFLAR Affinity Capture-Western physical 10837247 CDC25A Affinity Capture-Western physical 7744247 CDC25A Reconstituted Complex physical 7744247 MAPK8IP3 Affinity Capture-Western physical 10523642 HRAS Two-hybrid physical 8628317 BRAF Affinity Capture-Western physical 11325826 BRAF Affinity Capture-Western physical 11325826 MAP3K1 Affinity Capture-Western physical 10969079 MAP3K1 Affinity Capture-Western physical 10969079 MAP3K1 Reconstituted Complex physical 10969079 PDGFRB Reconstituted Complex physical 2475255 YWHAB Reconstituted Complex physical 12360521 MAP3K5 Affinity Capture-Western physical 11427728 MAP3K5 Reconstituted Complex physical 11427728 RAP1A Reconstituted Complex physical 9867809 MAPK7 Affinity Capture-Western physical 10531364 MAPK7 Reconstituted Complex physical 10531364 PHB Affinity Capture-Western physical 10523633 PHB Reconstituted Complex physical 10523633 RB1 Reconstituted Complex physical 10523633 PHB Reconstituted Complex physical 10523633 RAP1A Reconstituted Complex physical 10454553 GRB10 Reconstituted Complex physical 9553107 GRB10 Two-hybrid physical 9553107 GRB10 Affinity Capture-Western physical 9553107 GRB10 Affinity Capture-Western physical 9553107 HRAS Reconstituted Complex physical 8530446 HRAS Affinity Capture-Western physical 8530446 BAG1 Reconstituted Complex physical 8692945 BAG1 Reconstituted Complex physical 8692945 BAG1 Two-hybrid physical 8692945 BAG1 Affinity Capture-Western physical 8692945 PAK1 Affinity Capture-Western physical 11733498 PAK1 Reconstituted Complex physical 11733498 PAK1 Biochemical Activity physical 11733498 YWHAB Affinity Capture-Western physical 10620507 YWHAG Affinity Capture-Western physical 10620507 YWHAQ Affinity Capture-Western physical 10620507 YWHAH Affinity Capture-Western physical 10620507 YWHAZ Affinity Capture-Western physical 10620507 PRKCZ Affinity Capture-Western physical 10620507 PRKCZ Affinity Capture-Western physical 10620507 PRKCZ Reconstituted Complex physical 10620507 RRAS Two-hybrid physical 10848612 PRPF6 Two-hybrid physical 10848612 YWHAB Two-hybrid physical 10848612 HRAS Reconstituted Complex physical 9150145 UBE2D2 Biochemical Activity physical 11676916 YWHAB Two-hybrid physical 8702721 YWHAH Affinity Capture-Western physical 8702721 YWHAE Affinity Capture-Western physical 8702721 HRAS Affinity Capture-Western physical 12379659 NR3C1 Affinity Capture-Western physical 11005817 CDC25A Affinity Capture-Western physical 9230211 YWHAB Two-hybrid physical 7644510 YWHAE Two-hybrid physical 7644510 LCK Affinity Capture-Western physical 8939988 LTK Affinity Capture-Western physical 8084603 JAK1 Affinity Capture-Western physical 9446616 YWHAQ Reconstituted Complex physical 8663231 YWHAZ Reconstituted Complex physical 10611249 XIAP Affinity Capture-Western physical 19011619 BIRC2 Reconstituted Complex physical 19011619 BIRC3 Reconstituted Complex physical 19011619 HSP90AA1 Affinity Capture-Western physical 19011619 STUB1 Affinity Capture-Western physical 19011619 STUB1 Reconstituted Complex physical 19011619 HRAS Reconstituted Complex physical 9154803 EEF1A1 Affinity Capture-Western physical 17332776 EEF1A1 Affinity Capture-Western physical 17332776 EEF1A1 Co-localization physical 17332776 RRAS Affinity Capture-Western physical 19805522 HSP90AA1 Affinity Capture-Western physical 20159553 CFLAR Affinity Capture-Western physical 16537561 UBC Affinity Capture-Western physical 16504566 HSP90AA1 Affinity Capture-Western physical 16504566 RB1 Reconstituted Complex physical 15485920 MAP2K1 Reconstituted Complex physical 15485920 RB1 Reconstituted Complex physical 15485920 MAP2K1 Reconstituted Complex physical 15485920 MAP2K1 Affinity Capture-Western physical 15485920 RB1 Affinity Capture-Western physical 15485920 RB1 Biochemical Activity physical 15485920 HSP90AA1 Affinity Capture-Western physical 17409432 HSP90AA1 Affinity Capture-Western physical 17699868 HSP90AA1 Affinity Capture-Western physical 20039095 HSPA8 Affinity Capture-Western physical 20039095 MYC Affinity Capture-MS physical 17314511 HSPA5 Reconstituted Complex physical 18064632 HSPA5 Affinity Capture-Western physical 18064632 HSPA5 Affinity Capture-Western physical 18064632 PEBP4 Affinity Capture-Western physical 19197339 PEBP4 Reconstituted Complex physical 19197339 CALM1 Affinity Capture-Western physical 11585916 SGK1 Affinity Capture-Western physical 20947508 YWHAZ Two-hybrid physical 22222486